Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Conor, McEwan"'
Autor:
Joshua Owen, Conor McEwan, Heather Nesbitt, Phurit Bovornchutichai, Raymond Averre, Mark Borden, Anthony P McHale, John F Callan, Eleanor Stride
Publikováno v:
PLoS ONE, Vol 11, Iss 12, p e0168088 (2016)
Hypoxia has been shown to be a key factor inhibiting the successful treatment of solid tumours. Existing strategies for reducing hypoxia, however, have shown limited efficacy and/or adverse side effects. The aim of this study was to investigate the p
Externí odkaz:
https://doaj.org/article/b5f4e39f1fe145db8a8595a12febe938
Autor:
Bridgeen Callan, John F. Callan, Barry O'Hagan, Anthony P. McHale, Conor McEwan, K Curtis, Nikolitsa Nomikou
Publikováno v:
Acta Biomaterialia. 49:414-421
A PLGA-based multifunctional biodegradable nanoparticle platform co-harboring hematoporphyrin and indocyanine green has been developed. In vitro studies demonstrate ultrasound and light stimulated generation of cytotoxic reactive oxygen species. In v
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::839b7b73fedd0bec21c086ac4aa81595
https://doi.org/10.1016/j.actbio.2016.11.031
https://doi.org/10.1016/j.actbio.2016.11.031
Publikováno v:
The journal of allergy and clinical immunology. In practice. 6(4)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68dd132bee4ce9dc3b0b17ceb18c54ea
https://pubmed.ncbi.nlm.nih.gov/29733981
https://pubmed.ncbi.nlm.nih.gov/29733981
Autor:
Conor McEwan, Heather Nesbitt, John F. Callan, Anthony P. McHale, James Davis, Sukanta Kamila, Bridgeen Callan, Colin Fowley, Jordan Atchison
Publikováno v:
Chemical Communications. 51:16832-16835
A new sensitiser (4) for use in photodynamic therapy (PDT) has been developed to enable control of ROS production as a function of pH. This pH dependent PDT behaviour was tested in HeLa cells and in SCID mice bearing human xenograft pancreatic cancer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc6cb0ede4b81d4c1f4075164de6c2d5
https://doi.org/10.1039/c5cc07022h
https://doi.org/10.1039/c5cc07022h
Autor:
John F. Callan, Heather Nesbitt, Anthony P. McHale, Iain G. Jack, Conor McEwan, Oisin N. Kavanagh, Philip Loan, Dean Nicholas, K.E. McKenna
Publikováno v:
Bioorganicmedicinal chemistry. 24(13)
Sonodynamic therapy (SDT) involves the activation of a non-toxic sensitiser drug using low-intensity ultrasound to produce cytotoxic reactive oxygen species (ROS). Given the low tissue attenuation of ultrasound, SDT provides a significant benefit ove
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2efbeaa3c7d8d04ce5cfba21d0b1b7a
https://pubmed.ncbi.nlm.nih.gov/27234890
https://pubmed.ncbi.nlm.nih.gov/27234890
Publikováno v:
Journal of Allergy and Clinical Immunology. 141:AB57
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f6f6b6ca4cdb9d47e00515974320d957
https://doi.org/10.1016/j.jaci.2017.12.185
https://doi.org/10.1016/j.jaci.2017.12.185
Autor:
Sukanta, Kamila, Conor, McEwan, David, Costley, Jordan, Atchison, Yinjie, Sheng, Graham R C, Hamilton, Colin, Fowley, John F, Callan
Publikováno v:
Topics in current chemistry. 370
The interest in Quantum Dots as a class of nanomaterials has grown considerably since their discovery by Ekimov and Efros in the early 1980s. Although this early work focussed primarily on CdSe-based nanocrystals, the field has now expanded to includ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::f61d282cfa59e3d7851040aa6acc22e3
https://pubmed.ncbi.nlm.nih.gov/26589510
https://pubmed.ncbi.nlm.nih.gov/26589510
Autor:
Conor McEwan, Eleanor Stride, Rifat Hamoudi, Sukanta Kamila, Anthony P. McHale, John F. Callan, Mark A. Borden, Heather Nesbitt, Joshua Owen, Bridgeen Callan, Mark A. Taylor, Nikolitsa Nomikou
Publikováno v:
Biomaterials. 80
In this manuscript we describe the preparation of an oxygen-loaded microbubble (O2MB) platform for the targeted treatment of pancreatic cancer using both sonodynamic therapy (SDT) and antimetabolite therapy. O2MB were prepared with either the sensiti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::297f70bb16ffaa6eb886806eea202500
https://pubmed.ncbi.nlm.nih.gov/26702983
https://pubmed.ncbi.nlm.nih.gov/26702983
Autor:
John F. Callan, Colin Fowley, Anthony P. McHale, Bridgeen McCaughan, Nikolitsa Nomikou, Conor McEwan
Publikováno v:
Langmuir : the ACS journal of surfaces and colloids. 30(49)
Microbubbles (MBs) have recently emerged as promising delivery vehicles for sensitizer drugs in sonodynamic therapy (SDT). The ability to selectively destroy the MB and activate the sensitizer using an external ultrasound trigger could provide a mini
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef6d02af8a999d8db6c56da69f5bcf5c
https://pubmed.ncbi.nlm.nih.gov/25409533
https://pubmed.ncbi.nlm.nih.gov/25409533
Autor:
Eleanor Stride, Colin Fowley, Nikolitsa Nomikou, david cochrane, John F. Callan, Conor McEwan, Anthony P. McHale, Constantin C. Coussios, Heather Nesbitt, Joshua Owen, Mark A. Borden
Publikováno v:
Journal of controlled release : official journal of the Controlled Release Society. 203
Tumour hypoxia represents a major challenge in the effective treatment of solid cancerous tumours using conventional approaches. As oxygen is a key substrate for Photo-/Sono-dynamic Therapy (PDT/SDT), hypoxia is also problematic for the treatment of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::521ebf0073318dd6065ebb564c08c824
https://pubmed.ncbi.nlm.nih.gov/25660073
https://pubmed.ncbi.nlm.nih.gov/25660073