Aberration in myeloid-derived pro-angiogenic cells in type-2 diabetes mellitus; implication for diabetic retinopathy?

Autor: Mahnaz Shariatzadeh, Trishika R.R. Binda, Conny van Holten-Neelen, Josianne C. ten Berge, Jose P. Martinez Ciriano, King T. Wong, Willem A. Dik, Pieter J.M. Leenen

Publikováno v: Frontiers in Ophthalmology, Vol 3 (2023)

PurposeDiabetic retinopathy (DR) is a major microvascular complication of type 2 diabetes mellitus (T2DM). Myelomonocytic proangiogenic cells (PAC) have been implicated in DR pathogenesis, but their functional and developmental abnormalities are uncl

Externí odkaz: https://doaj.org/article/c1f09fd8d8ac435f869319b88800a033

Basic Fibroblast Growth Factor Induces Adipogenesis in Orbital Fibroblasts: Implications for the Pathogenesis of Graves' Orbitopathy

Autor: Sita Virakul, Willem A. Dik, Merel A Kooiman, P. Martin van Hagen, Dion Paridaens, Virgil A. S. H. Dalm, Conny van Holten-Neelen, Robin P. Peeters, Benjamin Schrijver, Esmee Kasteleijn

Publikováno v: Thyroid, 29(3), 395-404. Mary Ann Liebert Inc.

Basic fibroblast growth factor (bFGF) has been implicated in the pathogenesis of Graves' orbitopathy (GO). It stimulates several processes, including hyaluronan synthesis, involved in orbital tissue volume expansion and may act synergistically with p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a38c5feebffb5f05abbc91ced5835e37
https://pure.eur.nl/en/publications/afa80d05-551f-40cf-a56c-38123ac86124

Factor Xa and thrombin stimulate proinflammatory and profibrotic mediator production by retinal pigment epithelial cells: a role in vitreoretinal disorders?

Autor: P. Martin van Hagen, Jeroen Bastiaans, Jan C. van Meurs, Marja Smits-Te Nijenhuis, Robert W A M Kuijpers, Marion J. Kolijn-Couwenberg, Conny van Holten-Neelen, Herbert Hooijkaas, Willem A. Dik

Publikováno v: Graefes Archive for Clinical and Experimental Ophthalmology, 251(7), 1723-1733. Springer-Verlag

BACKGROUND: Vitreoretinal disorders, including proliferative vitreoretinopathy (PVR), proliferative diabetic retinopathy (PDR) and exudative age-related macular degeneration (AMD), are a major cause of visual impairment worldwide and can lead to blin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d81d6eab8b64b545832a827880eacdbf
https://hdl.handle.net/1765/68011

Dietary Restriction Modifies Certain Aspects of the Postoperative Acute Phase Response

Autor: Jan H.J. Hoeijmakers, Tessa M van Ginhoven, Jan N. M. IJzermans, Willem A. Dik, Ron W. F. de Bruin, Marja Smits-Te Nijenhuis, Herbert Hooijkaas, James R. Mitchell, Conny van Holten-Neelen

Publikováno v: Journal of Surgical Research, 171(2), 582-589. Academic Press

Background. Lifespan extension is achieved through long-term application of dietary restriction (DR), and benefits of short-term dietary restriction on acute stress and inflammation have been observed. So far, the effects of short-term DR in humans a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::516fd526060dec725e065499e05c8600
https://doi.org/10.1016/j.jss.2010.03.038

Reduced experimental autoimmune encephalomyelitis after intranasal and oral administration of recombinant lactobacilli expressing myelin antigens

Autor: Conny van Holten-Neelen, Jon D. Laman, Linsy Hoogteijling, Wim J. A. Boersma, C.B.M. Maassen, Lizette Visser, Eric Claassen, M.M. Schellekens, Lizet Groenewegen

Publikováno v: Vaccine, 21(32), 4685-4693
Maassen, C B M, Laman, J D, van Holten-Neelen, C, Hoogteijling, L, Groenewegen, L, Visser, L, Schellekens, M M, Boersma, W J A & Claassen, E H J H M 2003, ' Reduced experimental autoimmune encephalomyelitis after intranasal and oral administration of recombinant lactobacilli expressing myelin antigens ', Vaccine, vol. 21, no. 32, pp. 4685-93 . https://doi.org/10.1016/S0264-410X(03)00522-X
Vaccine, 21(32), 4685-93. Elsevier BV
Vaccine 21 (2003) 32
Vaccine, 21, 4685-4693. Elsevier

Oral administration of autoantigens is a safe and convenient way to induce peripheral T-cell tolerance in autoimmune diseases like multiple sclerosis (MS). To increase the efficacy of oral tolerance induction and obviate the need for large-scale puri

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea097cfd47c6489fccd57e4b7ec90d37
https://doi.org/10.1016/s0264-410x(03)00522-x