Zobrazeno 1 - 10 of 12 pro vyhledávání: '"Conny Wirtz"'
1
Total Synthesis of Limaol
Autor: Alois Fürstner, Xiaobin Mo, Conny Wirtz, Stephan N Hess
Publikováno v: Journal of the American Chemical Society
A nonthermodynamic array of four skipped methylene substituents on the hydrophobic tail renders limaol, a C40-polyketide of marine origin, unique in structural terms. This conspicuous segment was assembled by a two-directional approach and finally co
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3357adca677688a624159b0b34f0478e
http://europepmc.org/articles/PMC7888267
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2
Collective Total Synthesis of Casbane Diterpenes: One Strategy, Multiple Targets
Autor: Lorenz E. Löffler, Alois Fürstner, Conny Wirtz
Publikováno v: Angewandte Chemie (International Ed. in English)
Of the more than 100 casbane diterpenes known to date, only the eponymous parent hydrocarbon casbene itself has ever been targeted by chemical synthesis. Outlined herein is a conceptually new approach that brings not a single but a variety of casbane
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a70d5cce23a99e013b7e1ac4ce6ea5e8
https://doi.org/10.1002/anie.202015243
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3
The Formosalides: Structure Determination by Total Synthesis
Autor: Marc Heinrich, Yonghoon Kwon, Alois Fürstner, Conny Wirtz, Saskia Schulthoff, James Y. Hamilton
Publikováno v: Angewandte Chemie (International Ed. in English)
Total synthesis allowed the constitution of the cytotoxic marine macrolides of the formosalide family to be confirmed and their previously unknown stereostructure to be assigned with confidence. The underlying blueprint was inherently modular to ensu
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22572b0a5fae12708fa215f21a02bc08
https://doi.org/10.1002/ange.202011472
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4
Total Synthesis of Belizentrin Methyl Ester: Report on a Likely Conquest
Autor: Felix Anderl, Alois Fürstner, Conny Wirtz, Sylvester Größl
Publikováno v: Angewandte Chemie. 130:10872-10877
The assigned structure of the dinoflagellate-derived toxin belizentrin was prepared by total synthesis in form of the corresponding methyl ester for stability reasons. The successful route features an unusual solution for the preparation of a recalci
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::021d20fd3fe09649a545a50a46ab1786
https://doi.org/10.1002/ange.201805125
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5
Total Synthesis of Disciformycin A and B: Unusually Exigent Targets of Biological Significance
Autor: Yonghoon Kwon, Saskia Schulthoff, Alois Fürstner, Quang Minh Dao, Conny Wirtz
Publikováno v: Chemistry - A European Journal. 24:109-114
The first total synthesis of the potent antibiotic disciformycin B (2) is described, which is exceptionally isomerization-prone and transforms into disciformycin A (1) even under notably mild conditions. To outweigh this bias, the approach to 2 hinge
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3b15e012731abfb7311e529a4662883
https://doi.org/10.1002/chem.201705550
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10
Total synthesis of woodrosin I--part 2: final stages involving RCM and an orthoester rearrangement
Autor: Fabien Jeanjean, Richard Mynott, Conny Wirtz, Patrick Razon, Alois Fuerstner
Publikováno v: Chemistry (Weinheim an der Bergstrasse, Germany). 9(1)
The completion of the first total synthesis of the complex resin glycoside woodrosin I (1) is outlined using the building blocks described in the preceding paper. Key steps involve the TMSOTf-catalyzed coupling of diol 2 with trichloroacetimidate 3 w
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37cd0df165dbd1e8119dfdb825bce1b0
https://pubmed.ncbi.nlm.nih.gov/12506388
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