Variability in quantitative analysis of atherosclerotic plaque inflammation using 18F-FDG PET/CT.

Autor: Karel-Jan D F Lensen, Alper M van Sijl, Alexandre E Voskuyl, Conny J van der Laken, Martijn W Heymans, Emile F I Comans, Mike T Nurmohamed, Yvo M Smulders, Ronald Boellaard

Publikováno v: PLoS ONE, Vol 12, Iss 8, p e0181847 (2017)

18F-FDG-PET(/CT) is increasingly used in studies aiming at quantifying atherosclerotic plaque inflammation. Considerable methodological variability exists. The effect of data acquisition and image analysis parameters on quantitative uptake measures,

Externí odkaz: https://doaj.org/article/8c7ad08000c04cc7b34542a77a375bce

Longitudinal immune monitoring of patients with resectable esophageal adenocarcinoma treated with Neoadjuvant PD-L1 checkpoint inhibition

Autor: Tom van den Ende, Aiarpi Ezdoglian, Lisanne M. Baas, Joyce Bakker, Sinéad M. Lougheed, Micaela Harrasser, Cynthia Waasdorp, Mark I. van Berge Henegouwen, Maarten C.C.M. Hulshof, Nadia Haj Mohammad, Richard van Hillegersberg, Stella Mook, Conny J. van der Laken, Nicole C.T. van Grieken, Sarah Derks, Maarten F. Bijlsma, Hanneke W.M. van Laarhoven, Tanja D. de Gruijl

Publikováno v: OncoImmunology, Vol 12, Iss 1 (2023)

ABSTRACTThe analysis of peripheral blood mononuclear cells (PBMCs) by flow cytometry holds promise as a platform for immune checkpoint inhibition (ICI) biomarker identification. Our aim was to characterize the systemic immune compartment in resectabl

Externí odkaz: https://doaj.org/article/875b94688d2a4d92a00af551e8bbb88a

Positron Emission Tomography to Improve Assessment of Interstitial Lung Disease in Patients With Systemic Sclerosis Eligible for Autologous Stem Cell Transplantation

Autor: Bo Broens, Conny J. van der Laken, Gerben J.C. Zwezerijnen, Esther J. Nossent, Lilian J. Meijboom, Julia Spierings, Jeska K. de Vries-Bouwstra, Jacob M. van Laar, Alexandre E. Voskuyl

Publikováno v: Frontiers in Immunology, Vol 13 (2022)

Positron emission tomography (PET) is a promising technique to improve the assessment of systemic sclerosis associated interstitial lung disease (SSc-ILD). This technique could be of particular value in patients with severe diffuse cutaneous SSc (dcS

Externí odkaz: https://doaj.org/article/7eb44a73a99d40ffbcf2c26fa3f4bd77

IgA Immune Complexes Induce Osteoclast-Mediated Bone Resorption

Autor: Annelot C. Breedveld, Melissa M. J. van Gool, Myrthe A. M. van Delft, Conny J. van der Laken, Teun J. de Vries, Ineke D. C. Jansen, Marjolein van Egmond

Publikováno v: Frontiers in Immunology, Vol 12 (2021)

ObjectiveAutoantibodies are detected in most patients with rheumatoid arthritis (RA) and can be of the IgM, IgG or IgA subclass. Correlations between IgA autoantibodies and more severe disease activity have been previously reported, but the functiona

Externí odkaz: https://doaj.org/article/6bcb64771b8540f6927d00225c1804d3

Favourable effect of a 'second hit' after 13 weeks in early RA non-responders: the Amsterdam COBRA treat-to-target randomized trial

Autor: Linda Hartman, Linda A Rasch, Samina A Turk, Marieke M ter Wee, Pit J S M Kerstens, Conny J van der Laken, Michael T Nurmohamed, Dirkjan van Schaardenburg, Lilian H D van Tuyl, Alexandre E Voskuyl, Maarten Boers, Willem F Lems

Publikováno v: Rheumatology (Oxford, England), 62(6), 2098-2105. Oxford University Press
Hartman, L, Rasch, L A, Turk, S A, ter Wee, M M, Kerstens, P J S M, van der Laken, C J, Nurmohamed, M T, van Schaardenburg, D, van Tuyl, L H D, Voskuyl, A E, Boers, M & Lems, W F 2023, ' Favourable effect of a 'second hit' after 13 weeks in early RA non-responders : the Amsterdam COBRA treat-to-target randomized trial ', Rheumatology (Oxford, England), vol. 62, no. 6, pp. 2098-2105 . https://doi.org/10.1093/rheumatology/keac582, https://doi.org/10.1093/rheumatology/keac582

Objective The aim of this study was to investigate the effect of treat-to-target combination therapy with intensification at 13 weeks in early RA. Methods Early RA patients were classified as being at high or low risk of worsening RA based on disease

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b279aed501a84b72c56f06168d21844
https://research.vumc.nl/en/publications/f6f86ced-4bc5-4986-9940-8edebc439842