Spontaneous spreading depolarizations originate subcortically in a novel mouse model of familial hemiplegic migraine type 2

Autor: Nico A. Jansen, Chelsey Linnenbank, Maarten Schenke, Rob A. Voskuyl, Maria S. Jorge, Georgii Krivoshein, Cor Breukel, Margot M. Linssen, Jill W.C. Claassens, Conny Brouwers, Sandra H. van Heiningen, Anders Heuck, Karin Lykke-Hartmann, Else A. Tolner, Arn M.J.M. van den Maagdenberg

Publikováno v: Neurobiology of Disease, Vol 202, Iss , Pp 106714- (2024)

The mechanisms of initiation of spreading depolarization (SD) are understudied due to a paucity of disease models with spontaneously occurring events. We here present a novel mouse model of familial hemiplegic migraine type 2 (FHM2), expressing the m

Externí odkaz: https://doaj.org/article/06ea3f35c9c3417aa35517e998fb1500

Involvement of virus-induced interferon production in IgG autoantibody-mediated anemia

Autor: Shozo Izui, Dan Su, Cor Breukel, J. Sjef Verbeek, Jill W. C. Claassens, Mélanie Gaignage, Conny Brouwers, Jean-Paul Coutelier, Margot M. Linssen, Sarah Legrain

Publikováno v: International Journal of Molecular Sciences, 22(16). MDPI
International Journal of Molecular Sciences
Volume 22
Issue 16
International Journal of Molecular Sciences, Vol 22, Iss 9027, p 9027 (2021)

Infection with viruses, such as the lactate dehydrogenase-elevating virus (LDV), is known to trigger the onset of autoimmune anemia through the enhancement of the phagocytosis of autoantibody-opsonized erythrocytes by activated macrophages. Type I in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5aebe3f03de742beeb5288e00b271c01
https://hdl.handle.net/1887/3213013

Immunogenicity of rat-neu+ mouse mammary tumours determines the T cell-dependent therapeutic efficacy of anti-neu monoclonal antibody treatment

Autor: Marieke F. Fransen, Cor Breukel, Hreinn Benonisson, Conny Brouwers, Thorbald van Hall, Marcel Camps, Ferry Ossendorp, J. Sjef Verbeek, Heng Sheng Sow, Jill W. C. Claassens, Margot M L Linssen

Publikováno v: Scientific Reports, 10(1):3933. Nature Publishing Group
Scientific Reports, Vol 10, Iss 1, Pp 1-9 (2020)
Scientific Reports, 10(1). NATURE PUBLISHING GROUP
Scientific Reports
Sow, H S, Benonisson, H, Brouwers, C, Linssen, M M, Camps, M, Breukel, C, Claassens, J, van Hall, T, Ossendorp, F, Fransen, M F & Verbeek, J S 2020, ' Immunogenicity of rat-neu + mouse mammary tumours determines the T cell-dependent therapeutic efficacy of anti-neu monoclonal antibody treatment ', Scientific Reports, vol. 10, no. 1, 3933 . https://doi.org/10.1038/s41598-020-60893-8

The use of Trastuzumab (Herceptin), a monoclonal antibody (mAb) targeting HER2/neu, results in an increased median survival in Her2+ breast cancer patients. The tumour mutational burden and the presence of tumour infiltrating lymphocytes (TILs) clear

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::abadcccdd41814f380571961e6ef5b02
https://research.vumc.nl/en/publications/8cf52725-66de-497d-b820-29a3c94ff100

FcγRI expression on macrophages is required for antibody-mediated tumor protection by cytomegalovirus-based vaccines

Autor: Cor Breukel, Heng Sheng Sow, Thorbald van Hall, Margot M. Linssen, Marieke F. Fransen, Ferry Ossendorp, Ramon Arens, Conny Brouwers, Jill W. C. Claassens, Anke Redeker, Hreinn Benonisson, Sjef Verbeek

Publikováno v: Oncotarget

Cytomegalovirus (CMV)-based vaccine vectors are promising vaccine platforms because they induce strong and long-lasting immune responses. Recently it has been shown that vaccination with a mouse CMV (MCMV) vector expressing the melanoma-specific anti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7057d33f179c5ac520b99a54c55ddb45
https://doi.org/10.18632/oncotarget.25630

FcγR interaction is not required for effective anti-PD-L1 immunotherapy but can add additional benefit depending on the tumor model

Autor: Heng Sheng, Sow, Hreinn, Benonisson, Cor, Breukel, Remco, Visser, Onno J H M, Verhagen, Arthur E H, Bentlage, Conny, Brouwers, Jill W C, Claassens, Margot M, Linssen, Marcel, Camps, Thorbald, van Hall, Ferry, Ossendorp, Marieke F, Fransen, Gestur, Vidarsson, J Sjef, Verbeek

Publikováno v: International journal of cancer. 144(2)

Immunomodulatory antibodies blocking interactions of coinhibitory receptors to their ligands such as CTLA-4, PD1 and PD-L1 on immune cells have shown impressive therapeutic efficacy in clinical studies. The therapeutic effect of these antibodies is m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::6fa9445e93b66321779ced19055756c7
https://pubmed.ncbi.nlm.nih.gov/30259976