The prostaglandin E2 EP3 receptor has disparate effects on islet insulin secretion and content in β-cells in a high-fat diet-induced mouse model of obesity.

Autor: Neuman, Joshua C., Reuter, Austin, Carbajal, Kathryn A., Schaid, Michael D., Kelly, Grant, Connors, Kelsey, Kaiser, Cecilia, Krause, Joshua, Hurley, Liam D., Olvera, Angela, Davis, Dawn Belt, Wisinski, Jaclyn A., Gannon, Maureen, Kimple, Michelle E.

Publikováno v: American Journal of Physiology: Endocrinology & Metabolism; May2024, Vol. 326 Issue 5, pE567-E576, 10p

Rat prostaglandin EP3 receptor is highly promiscuous and is the sole prostanoid receptor family member that regulates INS1 (832/3) cell glucose-stimulated insulin secretion.

Autor: Sandhu, Harpreet K., Neuman, Joshua C., Schaid, Michael D., Davis, Sarah E., Connors, Kelsey M., Challa, Romith, Guthery, Erin, Fenske, Rachel J., Patibandla, Chinmai, Breyer, Richard M., Kimple, Michelle E.

Publikováno v: Pharmacology Research & Perspectives; Apr2021, Vol. 9 Issue 2, p1-11, 11p

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The prostaglandin E 2 EP3 receptor has disparate effects on islet insulin secretion and content in β-cells in a high-fat diet-induced mouse model of obesity.

Autor: Neuman JC; Research Service, William S. Middleton Memorial Veterans Hospital, Madison, Wisconsin, United States.; Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, University of Wisconsin-Madison, Madison, Wisconsin, United States., Reuter A; Research Service, William S. Middleton Memorial Veterans Hospital, Madison, Wisconsin, United States.; Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, University of Wisconsin-Madison, Madison, Wisconsin, United States., Carbajal KA; Research Service, William S. Middleton Memorial Veterans Hospital, Madison, Wisconsin, United States.; Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, University of Wisconsin-Madison, Madison, Wisconsin, United States., Schaid MD; Research Service, William S. Middleton Memorial Veterans Hospital, Madison, Wisconsin, United States.; Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, University of Wisconsin-Madison, Madison, Wisconsin, United States., Kelly G; Research Service, William S. Middleton Memorial Veterans Hospital, Madison, Wisconsin, United States.; Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, University of Wisconsin-Madison, Madison, Wisconsin, United States., Connors K; Research Service, William S. Middleton Memorial Veterans Hospital, Madison, Wisconsin, United States.; Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, University of Wisconsin-Madison, Madison, Wisconsin, United States., Kaiser C; Research Service, William S. Middleton Memorial Veterans Hospital, Madison, Wisconsin, United States.; Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, University of Wisconsin-Madison, Madison, Wisconsin, United States., Krause J; Department of Biology, University of Wisconsin-Lacrosse, La Crosse, Wisconsin, United States., Hurley LD; Research Service, William S. Middleton Memorial Veterans Hospital, Madison, Wisconsin, United States.; Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, University of Wisconsin-Madison, Madison, Wisconsin, United States., Olvera A; Research Service, William S. Middleton Memorial Veterans Hospital, Madison, Wisconsin, United States.; Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, University of Wisconsin-Madison, Madison, Wisconsin, United States., Davis DB; Research Service, William S. Middleton Memorial Veterans Hospital, Madison, Wisconsin, United States.; Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, University of Wisconsin-Madison, Madison, Wisconsin, United States., Wisinski JA; Department of Biology, University of Wisconsin-Lacrosse, La Crosse, Wisconsin, United States., Gannon M; Division of Diabetes, Endocrinology, and Metabolism, Department of Medicine, Vanderbilt University Medical Center, Nashville, Wisconsin, United States., Kimple ME; Research Service, William S. Middleton Memorial Veterans Hospital, Madison, Wisconsin, United States.; Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, University of Wisconsin-Madison, Madison, Wisconsin, United States.; Department of Cell and Regenerative Biology, University of Wisconsin-Madison, Madison, Wisconsin, United States.

Publikováno v: American journal of physiology. Endocrinology and metabolism [Am J Physiol Endocrinol Metab] 2024 May 01; Vol. 326 (5), pp. E567-E576. Date of Electronic Publication: 2024 Mar 13.