Supplementary Data from Serum- and Glucocorticoid-induced Kinase Sgk1 Directly Promotes the Differentiation of Colorectal Cancer Cells and Restrains Metastasis

Autor: Ian Tomlinson, Shazia Irshad, Stefania Segditsas, Chiara Bardella, Tia Mirshahi, Sujata Biswas, Thomas Starkey, Connor Woolley, Lennard Y.W. Lee

Supplementary Table 1. Differentially expressed genes from colonic crypt tops vs. bottoms of normal individuals (adjusted p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bea0aeccbf160beddb08a6404a21b2a9
https://doi.org/10.1158/1078-0432.22475289.v1

Serum- and Glucocorticoid-induced Kinase Sgk1 Directly Promotes the Differentiation of Colorectal Cancer Cells and Restrains Metastasis

Autor: Lennard Y W Lee, Shazia Irshad, Chiara Bardella, Sujata Biswas, Stefania Segditsas, Connor Woolley, Tia S Mirshahi, Thomas Starkey, Ian Tomlinson

Publikováno v: Clinical Cancer Research. 25:629-640

Purpose: The molecular events that determine intestinal cell differentiation are poorly understood and it is unclear whether it is primarily a passive event or an active process. It is clinically important to gain a greater understanding of the proce

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2e7b4e0f9cf9f8b9b7e76191f87d7e1
https://doi.org/10.1158/1078-0432.ccr-18-1033

The polymorphic variant rs1800734 influences methylation acquisition and allele-specific TFAP4 binding in the MLH1 promoter leading to differential mRNA expression

Autor: Tim Maughan, Davide Trapani, Daniela Furlan, Ian Tomlinson, Hayley Davis, Rachael Thomas, Simon J. Leedham, Annabelle Lewis, Lily Goodyer-Sait, Connor Woolley, Marketa Tomkova, Ceres Fernandez-Rozadilla, Skirmantas Kriaucionis, Laura Chegwidden, Nora Sahnane, Claire Palles

Publikováno v: Scientific Reports
Scientific Reports, Vol 9, Iss 1, Pp 1-10 (2019)
Thomas, R, Trapani, D, Goodyer-sait, L, Tomkova, M, Fernandez-rozadilla, C, Sahnane, N, Woolley, C, Davis, H, Chegwidden, L, Kriaucionis, S, Maughan, T, Leedham, S, Palles, C, Furlan, D, Tomlinson, I & Lewis, A 2019, ' The polymorphic variant rs1800734 influences methylation acquisition and allele-specific TFAP4 binding in the MLH1 promoter leading to differential mRNA expression ', Scientific Reports, vol. 9, no. 1 . https://doi.org/10.1038/s41598-019-49952-x

The raw data is available on Mendeley at https://data.mendeley.com/datasets/hfpbctm7tg/draft?a=1c91e494-cadc-4be0-a8ff-91d8736a28e7 © The Author(s) 2019. Expression of the mismatch repair gene MutL homolog 1 (MLH1) is silenced in a clinically import

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22fcd0b13b780081f7bdb3dd82a56bdd
https://doi.org/10.1038/s41598-019-49952-x

Correction: Telomere length and genetics are independent colorectal tumour risk factors in an evaluation of biomarkers in normal bowel

Autor: Deb Whittington, Michael McClellan, Ian Tomlinson, Gareth Horgan, Skirmantas Kriaucionis, James E. East, Christiana Kartsonaki, Ceres Fernandez-Rozadilla, Simon J. Leedham, Connor Woolley

Publikováno v: British Journal of Cancer. 118:1683-1683

Since the publication of this paper, the authors noticed that James E. East was assigned to the incorrect affiliation. The affiliation information is provided correctly, above.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d4e1070aa623f070e2c085264f3207b5
https://doi.org/10.1038/s41416-018-0111-0