Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Connor V. Duffy"'
Autor:
Julia A. Belk, Winnie Yao, Nghi Ly, Katherine A. Freitas, Yan-Ting Chen, Quanming Shi, Alfredo M. Valencia, Eric Shifrut, Nupura Kale, Kathryn E. Yost, Connor V. Duffy, Madeline A. Hwee, Zhuang Miao, Alan Ashworth, Crystal L. Mackall, Alexander Marson, Julia Carnevale, Santosh A. Vardhana, Ansuman T. Satpathy
T cell exhaustion limits anti-tumor immunity, but the molecular determinants of this process remain poorly understood. Using a chronic antigen stimulation assay, we performed genome-wide CRISPR/Cas9 screens to systematically discover genetic regulato
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f43c061aa8589a9656067aa9ec535a2a
https://doi.org/10.1101/2022.04.20.488974
https://doi.org/10.1101/2022.04.20.488974
Autor:
Jingyi Wei, Peter Lotfy, Kian Faizi, Eleanor Wang, Hannah Slabodkin, Emily Kinnaman, Sita Chandrasekaran, Hugo Kitano, Matthew G. Durrant, Connor V. Duffy, Patrick D. Hsu, Silvana Konermann
Transcriptome engineering requires flexible RNA-targeting technologies that can perturb mammalian transcripts in a robust and scalable manner. CRISPR systems that natively target RNA molecules, such as Cas13 enzymes, are enabling rapid progress in th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b42de4f1b6f42043b2b4e4e9495ac3ae
https://doi.org/10.1101/2021.09.14.460134
https://doi.org/10.1101/2021.09.14.460134
Autor:
Julia A. Belk, Winnie Yao, Nghi Ly, Katherine A. Freitas, Yan-Ting Chen, Quanming Shi, Alfredo M. Valencia, Eric Shifrut, Nupura Kale, Kathryn E. Yost, Connor V. Duffy, Bence Daniel, Madeline A. Hwee, Zhuang Miao, Alan Ashworth, Crystal L. Mackall, Alexander Marson, Julia Carnevale, Santosh A. Vardhana, Ansuman T. Satpathy
Publikováno v:
Cancer cell. 40(7)
T cell exhaustion limits antitumor immunity, but the molecular determinants of this process remain poorly understood. Using a chronic stimulation assay, we performed genome-wide CRISPR-Cas9 screens to systematically discover regulators of T cell exha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0dacdea49b2072b30899d9003ffab7b3
https://pubmed.ncbi.nlm.nih.gov/35820395
https://pubmed.ncbi.nlm.nih.gov/35820395
Autor:
Scott B. Biering, Sylvia A. Sarnik, Eleanor Wang, James R. Zengel, Sarah R. Leist, Alexandra Schäfer, Varun Sathyan, Padraig Hawkins, Kenichi Okuda, Cyrus Tau, Aditya R. Jangid, Connor V. Duffy, Jin Wei, Rodney C. Gilmore, Mia Madel Alfajaro, Madison S. Strine, Xammy Nguyenla, Erik Van Dis, Carmelle Catamura, Livia H. Yamashiro, Julia A. Belk, Adam Begeman, Jessica C. Stark, D. Judy Shon, Douglas M. Fox, Shahrzad Ezzatpour, Emily Huang, Nico Olegario, Arjun Rustagi, Allison S. Volmer, Alessandra Livraghi-Butrico, Eddie Wehri, Richard R. Behringer, Dong-Joo Cheon, Julia Schaletzky, Hector C. Aguilar, Andreas S. Puschnik, Brian Button, Benjamin A. Pinsky, Catherine A. Blish, Ralph S. Baric, Wanda K. O’Neal, Carolyn R. Bertozzi, Craig B. Wilen, Richard C. Boucher, Jan E. Carette, Sarah A. Stanley, Eva Harris, Silvana Konermann, Patrick D. Hsu
Publikováno v:
Nature genetics, vol 54, iss 8
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes a range of symptoms in infected individuals, from mild respiratory illness to acute respiratory distress syndrome. A systematic understanding of host factors influencing viral infect
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ffaf01d8d1c988237dde84b12c408fe
https://pubmed.ncbi.nlm.nih.gov/35879412
https://pubmed.ncbi.nlm.nih.gov/35879412
Autor:
Jeffrey M. Granja, Quanming Shi, Howard Y. Chang, Zhe Liu, Robert Tjian, Connor V. Duffy, Paul S. Mischel, Vineet Bafna, Katerina Kraft, Kathryn E. Yost, Sihan Wu, Joshua T. Lange, Jun Tang, Utkrisht Rajkumar, M. Ryan Corces, John C. Rose, Liangqi Xie, King L. Hung, Rui Li
Extrachromosomal DNAs (ecDNAs) are prevalent in human cancers and mediate high oncogene expression through elevated copy number and altered gene regulation1. Gene expression typically involves distal enhancer DNA elements that contact and activate ge
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c3cf91da2fe1625888f195d7fba475ee
https://doi.org/10.1101/2020.11.19.390278
https://doi.org/10.1101/2020.11.19.390278
Autor:
Robert Schöpflin, Vineet Bafna, Liangqi Xie, Konstantin Helmsauer, M. Ryan Corces, Natasha E. Weiser, Zhe Liu, Anton G. Henssen, Anindya Bagchi, Howard Y. Chang, Utkrisht Rajkumar, Rui Li, Katerina Kraft, Kathryn E. Yost, Robert Tjian, Sihan Wu, Julia A. Belk, Jens Luebeck, Siavash R. Dehkordi, King L. Hung, Celine Chen, Paul S. Mischel, Ivy Tsz-Lo Wong, Jun Tang, Jordan Friedlein, Stefan Mundlos, Quanming Shi, Joshua T. Lange, Rocío Chamorro González, Connor V. Duffy, John C. Rose, M. E. Valieva, Jeffrey M. Granja, Ansuman T. Satpathy
Publikováno v:
Nature
Extrachromosomal DNA (ecDNA) is prevalent in human cancers and mediates high expression of oncogenes through gene amplification and altered gene regulation1. Gene induction typically involves cis-regulatory elements that contact and activate genes on
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75aa2a48153e2856eee8040144c00d2d
https://pubmed.ncbi.nlm.nih.gov/35120647
https://pubmed.ncbi.nlm.nih.gov/35120647
Publikováno v:
Acta Biomaterialia
Acta Biomaterialia, Elsevier, 2015, 20, pp.51-59. ⟨10.1016/j.actbio.2015.03.024⟩
Acta Biomaterialia, Elsevier, 2015, 20, pp.51-59. ⟨10.1016/j.actbio.2015.03.024⟩
International audience; The sustained delivery of both hydrophobic and hydrophilic drugs from hydrogels has remained a challenge requiring the design and scalable production of complex multifunctional synthetic polymers. Here, we demonstrate that muc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58d65278822649554c2c8d875bab4aef