Zobrazeno 1 - 10
of 63
pro vyhledávání: '"Connor Scott"'
Autor:
Simon Davis, Connor Scott, Janina Oetjen, Philip D. Charles, Benedikt M. Kessler, Olaf Ansorge, Roman Fischer
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
Abstract The spatial organisation of cellular protein expression profiles within tissue determines cellular function and is key to understanding disease pathology. To define molecular phenotypes in the spatial context of tissue, there is a need for u
Externí odkaz:
https://doaj.org/article/a9c62d9e72e54c4baedf487a7e9f1c8a
Autor:
Amy F. D. Howard, Istvan N. Huszar, Adele Smart, Michiel Cottaar, Greg Daubney, Taylor Hanayik, Alexandre A. Khrapitchev, Rogier B. Mars, Jeroen Mollink, Connor Scott, Nicola R. Sibson, Jerome Sallet, Saad Jbabdi, Karla L. Miller
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-18 (2023)
Abstract Understanding brain structure and function often requires combining data across different modalities and scales to link microscale cellular structures to macroscale features of whole brain organisation. Here we introduce the BigMac dataset,
Externí odkaz:
https://doaj.org/article/106cfe8ccd9d47aba3d111a96d0102fd
Autor:
Daniel Z.L. Kor, Saad Jbabdi, Istvan N. Huszar, Jeroen Mollink, Benjamin C. Tendler, Sean Foxley, Chaoyue Wang, Connor Scott, Adele Smart, Olaf Ansorge, Menuka Pallebage-Gamarallage, Karla L. Miller, Amy F.D. Howard
Publikováno v:
NeuroImage, Vol 264, Iss , Pp 119726- (2022)
The acquisition of MRI and histology in the same post-mortem tissue sample enables direct correlation between MRI and histologically-derived parameters. However, there still lacks a standardised automated pipeline to process histology data, with most
Externí odkaz:
https://doaj.org/article/f5ef11d9b2664f16ba61b7dd89eb334b
Autor:
Nora Bengoa-Vergniory, Elisavet Velentza-Almpani, Ana Maria Silva, Connor Scott, Mariana Vargas-Caballero, Magdalena Sastre, Richard Wade-Martins, Javier Alegre-Abarrategui
Publikováno v:
Acta Neuropathologica Communications, Vol 9, Iss 1, Pp 1-20 (2021)
Abstract Background Multimerization is a key process in prion-like disorders such as Alzheimer’s disease (AD), since it is a requirement for self-templating tau and beta-amyloid amyloidogenesis. AT8-immunohistochemistry for hyperphosphorylated tau
Externí odkaz:
https://doaj.org/article/95ebe064b735404f8b092f9ef16f8cee
Autor:
Matthew Nolan, Connor Scott, Menuka Pallebage Gamarallage, Daniel Lunn, Kilda Carpenter, Elizabeth McDonough, Dan Meyer, Sireesha Kaanumalle, Alberto Santamaria-Pang, Martin R. Turner, Kevin Talbot, Olaf Ansorge
Publikováno v:
Acta Neuropathologica Communications, Vol 8, Iss 1, Pp 1-20 (2020)
Abstract Degeneration of the primary motor cortex is a defining feature of amyotrophic lateral sclerosis (ALS), which is associated with the accumulation of microscopic protein aggregates in neurons and glia. However, little is known about the quanti
Externí odkaz:
https://doaj.org/article/c03d43de02b54760b1db4ca868517f34
Autor:
Benjamin C Tendler, Taylor Hanayik, Olaf Ansorge, Sarah Bangerter-Christensen, Gregory S Berns, Mads F Bertelsen, Katherine L Bryant, Sean Foxley, Martijn P van den Heuvel, Amy FD Howard, Istvan N Huszar, Alexandre A Khrapitchev, Anna Leonte, Paul R Manger, Ricarda AL Menke, Jeroen Mollink, Duncan Mortimer, Menuka Pallebage-Gamarallage, Lea Roumazeilles, Jerome Sallet, Lianne H Scholtens, Connor Scott, Adele Smart, Martin R Turner, Chaoyue Wang, Saad Jbabdi, Rogier B Mars, Karla L Miller
Publikováno v:
eLife, Vol 11 (2022)
Post-mortem magnetic resonance imaging (MRI) provides the opportunity to acquire high-resolution datasets to investigate neuroanatomy and validate the origins of image contrast through microscopy comparisons. We introduce the Digital Brain Bank (open
Externí odkaz:
https://doaj.org/article/b98bea2df069462e8087d79c5cbb6996
Autor:
David Gordon, Ruxandra Dafinca, Jakub Scaber, Javier Alegre-Abarrategui, Lucy Farrimond, Connor Scott, Daniel Biggs, Louisa Kent, Peter L. Oliver, Benjamin Davies, Olaf Ansorge, Richard Wade-Martins, Kevin Talbot
Publikováno v:
Neurobiology of Disease, Vol 121, Iss , Pp 148-162 (2019)
Mutations in the gene encoding the RNA-binding protein TDP-43 cause amyotrophic lateral sclerosis (ALS), clinically and pathologically indistinguishable from the majority of ‘sporadic’ cases of ALS, establishing altered TDP-43 function and distri
Externí odkaz:
https://doaj.org/article/192a3fbab9434e70aeee4440b8061102
Autor:
Benjamin C. Tendler, Sean Foxley, Moises Hernandez-Fernandez, Michiel Cottaar, Connor Scott, Olaf Ansorge, Karla L. Miller, Saad Jbabdi
Publikováno v:
NeuroImage, Vol 220, Iss , Pp 117113- (2020)
Diffusion-weighted steady-state free precession (DW-SSFP) is an SNR-efficient diffusion imaging method. The improved SNR and resolution available at ultra-high field has motivated its use at 7T. However, these data tend to have severe B1 inhomogeneit
Externí odkaz:
https://doaj.org/article/362f0aaaf4bf4599ad06b54fd8c7122f
