Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Connor McGuckin"'
Autor:
Ulrike Gerdemann, Ryan A. Fleming, James Kaminski, Connor McGuckin, Xianliang Rui, Jennifer F. Lane, Paula Keskula, Lorenzo Cagnin, Alex K. Shalek, Victor Tkachev, Leslie S. Kean
Publikováno v:
Frontiers in Immunology, Vol 12 (2022)
T cell receptor (TCR) clonotype tracking is a powerful tool for interrogating T cell mediated immune processes. New methods to pair a single cell’s transcriptional program with its TCR identity allow monitoring of T cell clonotype-specific transcri
Externí odkaz:
https://doaj.org/article/42d351debbd144dfad3a35b0b215ba3f
Autor:
Alejandro Gutierrez, Lukas E. Dow, Kimmie Ng, Marios Giannakis, Ewa Sicinska, Chen Yuan, Martin Stanulla, Florence Wagner, Joshua R. Sacher, Connor McGuckin, Salmaan Karim, Sabine Schreek, Emma M. Schatoff, Teng Han, James Degar, Roxane Labrosse, Laura Hinze
Supplementary Table 2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17b33c396e6eddd4fc3c1bf1992633b6
https://doi.org/10.1158/2159-8290.22534993.v1
https://doi.org/10.1158/2159-8290.22534993.v1
Autor:
Alejandro Gutierrez, Lukas E. Dow, Kimmie Ng, Marios Giannakis, Ewa Sicinska, Chen Yuan, Martin Stanulla, Florence Wagner, Joshua R. Sacher, Connor McGuckin, Salmaan Karim, Sabine Schreek, Emma M. Schatoff, Teng Han, James Degar, Roxane Labrosse, Laura Hinze
Supplementary Figures S1-S11
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::783fdd4ad1088ca6401c78956bbb409f
https://doi.org/10.1158/2159-8290.22534999.v1
https://doi.org/10.1158/2159-8290.22534999.v1
Autor:
Alejandro Gutierrez, Lukas E. Dow, Kimmie Ng, Marios Giannakis, Ewa Sicinska, Chen Yuan, Martin Stanulla, Florence Wagner, Joshua R. Sacher, Connor McGuckin, Salmaan Karim, Sabine Schreek, Emma M. Schatoff, Teng Han, James Degar, Roxane Labrosse, Laura Hinze
Colorectal cancer is driven by mutations that activate canonical WNT/β-catenin signaling, but inhibiting WNT has significant on-target toxicity, and there are no approved therapies targeting dominant oncogenic drivers. We recently found that activat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3aa49176de370c6f0d97ccfed657309c
https://doi.org/10.1158/2159-8290.c.6547729.v1
https://doi.org/10.1158/2159-8290.c.6547729.v1
Autor:
Chunyan Ren, Scot A. Wolfe, Luca Pinello, Qiuming Yao, Jing Zeng, Mitchel A. Cole, Mir A. Hossain, Daniel E. Bauer, Kevin Luk, Connor McGuckin, Divya S. Vinjamur
Publikováno v:
Nature Genetics. 53:719-728
Known fetal hemoglobin (HbF) silencers have potential on-target liabilities for rational β-hemoglobinopathy therapeutic inhibition. Here, through transcription factor (TF) CRISPR screening, we identify zinc-finger protein (ZNF) 410 as an HbF repress
Autor:
Xianliang Rui, Francesca Alvarez Calderon, Ulrike Gerdemann, Connor McGuckin, Lorenzo Cagnin, Bruce R. Blazar, Victor Tkachev, Leslie S. Kean
Publikováno v:
Blood. 140:871-872
Autor:
Ulrike Gerdemann, James Kaminski, Ryan A Fleming, Victor Tkachev, Francesca Alvarez Calderon, Connor McGuckin, Xianliang Rui, Jennifer Lane, Alex K. Shalek, Leslie Kean
Publikováno v:
Blood. 140:1167-1168
Autor:
Victor Tkachev, Ashley Vanderbeck, Eric Perkey, Scott N. Furlan, Connor McGuckin, Daniela Gómez Atria, Ulrike Gerdemann, Xianliang Rui, Jennifer Lane, Daniel J. Hunt, Hengqi Zheng, Lucrezia Colonna, Michelle Hoffman, Alison Yu, Samantha Kelly, Anneka Allman, Brandon Burbach, Yoji Shimizu, Angela Panoskaltsis-Mortari, Guoying Chen, Stephen M. Carpenter, Olivier Harari, Frank Kuhnert, Gavin Thurston, Bruce R. Blazar, Leslie S. Kean, Ivan Maillard
Notch signaling promotes T-cell pathogenicity and graft-versus-host disease (GVHD) after allogeneic hematopoietic cell transplantation (allo-HCT) in mice, with a dominant role for the Delta-like ligand DLL4. To assess if Notch’s effects are evoluti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d7537e5f3939cb946abc2aed68e7ba97
https://doi.org/10.1101/2022.04.23.488844
https://doi.org/10.1101/2022.04.23.488844
Autor:
Laura Hinze, Sabine Schreek, Andre Zeug, Nurul Khalida Ibrahim, Beate Fehlhaber, Lorent Loxha, Buesra Cinar, Evgeni Ponimaskin, James Degar, Connor McGuckin, Gabriela Chiosis, Cornelia Eckert, Gunnar Cario, Beat Bornhauser, Jean-Pierre Bourquin, Martin Stanulla, Alejandro Gutierrez
The tolerance of amino acid starvation is fundamental to robust cellular fitness. Asparagine depletion is lethal to some cancer cells, a vulnerability that can be exploited clinically. We report that resistance to asparagine starvation is uniquely de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7810dda4ad470420e9e2a00ff8fa526c
Autor:
Ulrike Gerdemann, Ryan A. Fleming, James Kaminski, Connor McGuckin, Xianliang Rui, Jennifer F. Lane, Paula Keskula, Lorenzo Cagnin, Alex K. Shalek, Victor Tkachev, Leslie S. Kean
Publikováno v:
Frontiers in Immunology, Vol 12 (2022)
T cell receptor clonotype tracking is a powerful tool for interrogating T cell mediated immune processes. New methods to pair a single cell’s transcriptional program with its T cell receptor (TCR) identity allow monitoring of T cell clonotype-speci