Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Connor M Blair"'
Autor:
Amit Mahindra, Gonzalo Tejeda, Mario Rossi, Omar Janha, Imogen Herbert, Caroline Morris, Danielle C Morgan, Wendy Beattie, Augusto C Montezano, Brian Hudson, Andrew B Tobin, David Bhella, Rhian M Touyz, Andrew G Jamieson, George S Baillie, Connor M Blair
Publikováno v:
PLoS ONE, Vol 16, Iss 11, p e0260283 (2021)
SARS-CoV-2 viral attachment and entry into host cells is mediated by a direct interaction between viral spike glycoproteins and membrane bound angiotensin-converting enzyme 2 (ACE2). The receptor binding motif (RBM), located within the S1 subunit of
Externí odkaz:
https://doaj.org/article/bd3f0fee6eca437982991ad72b197890
Autor:
Sean F. Cooke, Thomas A. Wright, Yuan Yan Sin, Jiayue Ling, Elka Kyurkchieva, Nattaporn Phanthaphol, Thomas Mcskimming, Katharine Herbert, Selma Rebus, Andrew V. Biankin, David K. Chang, George S. Baillie, Connor M. Blair
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-16 (2024)
Abstract Pancreatic ductal adenocarcinoma (PDAC) is considered the third leading cause of cancer mortality in the western world, offering advanced stage patients with few viable treatment options. Consequently, there remains an urgent unmet need to d
Externí odkaz:
https://doaj.org/article/16d4a69d0ef14307a98c84f3b800fbc9
Autor:
Jawad S Khalil, Paulo A. Saldanha, Connor M Blair, Jiayue Ling, Wei Ji, George S. Baillie, Khalid M Naseem, Leonid L Nikitenko, Francisco Rivero
The activity of myosin light chain phosphatase (MLCP) is fine-tuned by the phosphorylation status of the MLCP target subunit 1 (MYPT1), which is determined by the antagonistic effects of Rho kinase (ROCK) and cAMP/cGMP-dependent protein kinases (PKA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ee74fe964fef6185883f51ab0f1c3e8a
https://doi.org/10.1101/2023.04.27.538407
https://doi.org/10.1101/2023.04.27.538407
Autor:
Alexandra D. Brown, Kathleen L. Vergunst, Makenzie Branch, Connor M. Blair, Denis J. Dupré, George S. Baillie, David N. Langelaan
The microphthalmia-associated transcription factor (MITF) is a master regulator of the melanocyte cell lineage. Aberrant MITF activity can lead to multiple malignancies including skin cancer, where it modulates the proliferation and invasiveness of m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3d8876f2e151cbef396eab8cb3107b34
https://doi.org/10.1101/2022.08.28.505448
https://doi.org/10.1101/2022.08.28.505448
Autor:
Nicola S Logan, Gonzalo S. Tejeda, Andrew G. Jamieson, Imogen Herbert, Connor M. Blair, David Bhella, Amit Mahindra, Gauthier Lieber, Matthew L. Turnbull, Caroline Morris, Danielle C. Morgan, George S. Baillie, Andrew B. Tobin, Brian O. Smith, Brian J. Willett
Publikováno v:
Peptide Science
Peptide Science (Hoboken, N.j.)
Peptide Science (Hoboken, N.j.)
COVID‐19 is caused by a novel coronavirus called severe acute respiratory syndrome‐coronavirus 2 (SARS‐CoV‐2). Virus cell entry is mediated through a protein‐protein interaction (PPI) between the SARS‐CoV‐2 spike protein and angiotensin
Autor:
Omar Janha, Gonzalo S. Tejeda, Andrew B. Tobin, Augusto C. Montezano, Amit Mahindra, Andrew G. Jamieson, Rhian M. Touyz, Caroline Morris, Danielle C. Morgan, Wendy Beattie, Connor M. Blair, Brian D. Hudson, Mario Rossi, Imogen Herbert, David Bhella, George S. Baillie
Publikováno v:
PLoS ONE, Vol 16, Iss 11, p e0260283 (2021)
PLoS ONE, Vol 16, Iss 11 (2021)
PLoS ONE
PLoS ONE, Vol 16, Iss 11 (2021)
PLoS ONE
SARS-CoV-2 viral attachment and entry into host cells is mediated by a direct interaction between viral spike glycoproteins and membrane bound angiotensin-converting enzyme 2 (ACE2). The receptor binding motif (RBM), located within the S1 subunit of
Autor:
Brian O. Smith, Amy J. Tibbo, William Fuller, George S. Baillie, Caglar Gök, Aisling McFall, Niall MacQuaide, Gonzalo S. Tejeda, Ruth MacLeod, Godfrey L. Smith, Connor M. Blair, Thomas Brand, Sara Dobi
Cyclic AMP is a ubiquitous second messenger used to transduce intracellular signals from a variety of Gs-coupled receptors. Compartmentalisation of protein intermediates within the cAMP signaling pathway underpins receptor-specific responses. The cAM
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::662d72da79fdb83266d8ecdc28d28a77
https://doi.org/10.1101/2020.09.10.290825
https://doi.org/10.1101/2020.09.10.290825
Publikováno v:
Bio Protoc
Fibrinolysis is an integral part of the matrix remodeling process that contributes to tissue repair. Fibrin clots are broken down during fibrinolysis in a controlled process. Fibrin degradation products (FDPs) have also been shown to have a role in t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9eff0d5dffc0df4bbe5fb483d59408d7
https://europepmc.org/articles/PMC7842290/
https://europepmc.org/articles/PMC7842290/
Publikováno v:
Bio Protoc
Cyclic nucleotide degrading phosphodiesterase (PDE) enzymes are crucial to the fine tuning of cAMP signaling responses, playing a pivotal role in regulating the temporal and spatial characteristics of discrete cAMP nanodomains and hence the activity
Autor:
George S. Baillie, Connor M. Blair
Spatio-temporal regulation of localised cAMP nanodomains is highly dependent upon the compartmentalised activity of phosphodiesterase (PDE) cyclic nucleotide degrading enzymes. Strategically positioned PDE–protein complexes are pivotal to the homeo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e7f1da31961d16982b9818602156815
https://eprints.gla.ac.uk/193977/7/193977.pdf
https://eprints.gla.ac.uk/193977/7/193977.pdf