Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Connor Jankowski"'
Autor:
Connor Jankowski, Joshua Rabinowitz
Publikováno v:
Cancer Res
High-dose ascorbate (vitamin C) has shown promising anticancer activity. Two redox mechanisms have been proposed: hydrogen peroxide generation by ascorbate itself or glutathione depletion by dehydroascorbate (formed by ascorbate oxidation). Here we s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e102cae65b31b3d83d8771e2118b7fb9
https://doi.org/10.1158/0008-5472.can-22-0408
https://doi.org/10.1158/0008-5472.can-22-0408
Autor:
Guilherme C. de Oliveira, Tamara Tchkonia, Karthikeyani Chellappa, Karina S. Kanamori, Connor Jankowski, Katie L. Thompson, Guillermo Agorrody, Joshua D. Rabinowitz, Amrutesh S. Puranik, James L. Kirkland, Jan M. van Deursen, Kevin Dang, Gina M. Warner, Claudia C.S. Chini, Micaela A. Witte, Eduardo N. Chini, Lilian S Gomez, Starlynn Clarke, Thais Peclat, Jair Machado Espindola-Netto, Melanie R. McReynolds, Kelly A. Hogan, Marco De Cecco, Wim Van Schooten, Darren J. Baker, Paola Vidal, Bennett G. Childs, Sonu Kashyap, Mariana G. Tarragó, Joseph A. Baur, Anna L. Kirkland, John M. Sedivy
Publikováno v:
Nature metabolism
Decreased nicotinamide adenine dinucleotide (NAD+) levels have been shown to contribute to metabolic dysfunction during aging. NAD+ decline can be partially prevented by knockout of the enzyme CD38. However, it is not known how CD38 is regulated duri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89f293082b523d28c2c49e835f21eb18
http://europepmc.org/articles/PMC8752031
http://europepmc.org/articles/PMC8752031
Autor:
Qingwei Chu, L. Ji, Joshua D. Rabinowitz, Sarmistha Mukherjee, Wei Lu, Christoph A. Thaiss, Faisal Hayat, Mikhail V. Makarov, K. Chellappa, T. Cox, Joseph A. Baur, Marie E. Migaud, Shawn M. Davidson, Yashaswini R. Bhat, Connor Jankowski, R. T. Shima, Melanie R. McReynolds, Xianfeng Zeng, S. R. Lingala, Hélène Descamps
Publikováno v:
Cell Metabolism. 34:1947-1959.e5
Nicotinamide adenine dinucleotide (NAD) is an essential redox cofactor in both mammals and microbes. Here we use isotope tracing to investigate the precursors supporting NAD synthesis in the gut microbiome. We find that preferred dietary NAD precurso
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a78e2f9869566b17aab73e6db08ced86
https://doi.org/10.1016/j.cmet.2022.11.004
https://doi.org/10.1016/j.cmet.2022.11.004
Autor:
Clayton J. Otter, William A. Hofstadter, Cora N. Betsinger, Connor Jankowski, Ileana M. Cristea, Pierre M. Jean Beltran, Joel D. Federspiel
Publikováno v:
Proc Natl Acad Sci U S A
Viruses modulate mitochondrial processes during infection to increase biosynthetic precursors and energy output, fueling virus replication. In a surprising fashion, although it triggers mitochondrial fragmentation, the prevalent pathogen human cytome
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cfd081d4dc61d4b79f04f4eb5dd4a1c1
https://doi.org/10.1073/pnas.2101675118
https://doi.org/10.1073/pnas.2101675118
Metabolic function in aging retina and retinal pigment epithelium remains robust despite vision loss
Autor:
David J. Marcinek, Jeremy Whitson, Mariya T. Sweetwyne, Celia M. Bisbach, Ian R. Sweet, Whitney M. Cleghorn, Ana P. Valencia, Connor Jankowski, Austin M. Rountree, James B. Hurley, Martin Sadilek, Kristine Tsantilas, Brian M. Robbings, Jonathan D. Linton, Peter S. Rabinovitch, Huiliang Zhang, Campbell, Daniel T. Hass
PurposeCharacterize how metabolic function in the murine retina and retinal pigment epithelium-choroid-sclera (eyecup) complex is impacted by natural aging.MethodsWe examined scotopic and photopic visual function of young (3-6 months) and aged (23-26
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::93d0e0ac6ee2a02761df0e803ff6cf39
https://doi.org/10.1101/2021.04.06.438698
https://doi.org/10.1101/2021.04.06.438698
Autor:
Li Chen, Sarmistha Mukherjee, Qingwei Chu, Wenyun Lu, Connor Jankowski, Joshua D. Rabinowitz, Cristoph Thaiss, Melanie R. McReynolds, Eric Chiles, Paul Botolin, Xiaoyang Su, Karthikeyani Chellappa, Joseph A. Baur, Hélène Descamps, Yishui Shen, Yashaswini R. Bhat
NAD+ is an essential coenzyme found in all living cells. NAD+ concentrations decline during aging, but whether this reflects impaired production or accelerated consumption remains unclear. Here we employed isotope tracing and mass spectrometry to pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3d7de65c62a578f6f605a34649df4503
https://doi.org/10.21203/rs.3.rs-86538/v1
https://doi.org/10.21203/rs.3.rs-86538/v1
Autor:
Tracy G. Anthony, Seunghun Han, Michel Nofal, David M. Sabatini, Martin Wühr, Lance Parsons, Connor Jankowski, Alexander N. Frese, Joshua D. Rabinowitz, Lifeng Yang, Zemer Gitai, Sophia Hsin-Jung Li, Timothy C. Wang
Publikováno v:
Cell Syst
Pancreatic cancer cells with limited access to free amino acids can grow by scavenging extracellular protein. In a murine model of pancreatic cancer, we performed a genome-wide CRISPR screen for genes required for scavenging-dependent growth. The scr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b88c3d95d854ed21ff6a9761f7aec8c0
https://doi.org/10.1016/j.cels.2021.09.014
https://doi.org/10.1016/j.cels.2021.09.014
Autor:
Marie E. Migaud, Yashaswini R. Bhat, Paul Botolin, Qingwei Chu, Katalin Susztak, Xiaoyang Su, Joseph A. Baur, Yihui Shen, Melanie R. McReynolds, Li Chen, Tomohito Doke, Eric Chiles, Karthikeyani Chellappa, Christoph A. Thaiss, Connor Jankowski, Faisal Hayat, Wenyun Lu, Hélène Descamps, Siddharth R. Lingala, Joshua D. Rabinowitz, Sarmistha Mukherjee
Publikováno v:
Cell Syst
NAD(+) is an essential coenzyme for all living cells. NAD(+) concentrations decline with age, but whether this reflects impaired production or accelerated consumption remains unclear. We employed isotope tracing and mass spectrometry to probe age-rel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47064dfe8d599d7c9ac880c2d5b93ad5
https://doi.org/10.1016/j.cels.2021.09.001
https://doi.org/10.1016/j.cels.2021.09.001
Autor:
Kristine Tsantilas, Robert E. Anderson, Ammaji Rajala, Richard S. Brush, James B. Hurley, Ken J. Lindsay, Raju V. S. Rajala, Jonathan D. Linton, Yuhong Wang, Connor Jankowski
Publikováno v:
Cell Death & Disease
Cell Death and Disease, Vol 9, Iss 2, Pp 1-18 (2018)
Cell Death and Disease, Vol 9, Iss 2, Pp 1-18 (2018)
Pyruvate kinase M2 (PKM2) is a glycolytic enzyme that is expressed in cancer cells. Its role in tumor metabolism is not definitively established, but investigators have suggested that regulation of PKM2 activity can cause accumulation of glycolytic i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::596537aaded6bb1fed2aa198ac22f9c8
https://pubmed.ncbi.nlm.nih.gov/29445082
https://pubmed.ncbi.nlm.nih.gov/29445082
Autor:
Mark A Kanow, Austin M. Rountree, Michelle M. Giarmarco, Ian R. Sweet, Christopher C. Farnsworth, Jonathan D. Linton, Abbi L. Engel, Susan E. Brockerhoff, James B. Hurley, Stephanie R. Sloat, Kristine Tsantilas, Ken J. Lindsay, Connor Jankowski, Jennifer R Chao, Edward D Parker, Jianhai Du, Martin Sadilek
Publikováno v:
eLife, Vol 6 (2017)
eLife
eLife
Here we report multiple lines of evidence for a comprehensive model of energy metabolism in the vertebrate eye. Metabolic flux, locations of key enzymes, and our finding that glucose enters mouse and zebrafish retinas mostly through photoreceptors su
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0dfbd1ef076f6c015176b68f3cc1c3f2
https://elifesciences.org/articles/28899
https://elifesciences.org/articles/28899