Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Connor J. Hughes"'
Autor:
Connor J. Hughes, Kaiah M. Fields, Etienne P. Danis, Jessica Y. Hsu, Deepika Neelakantan, Melanie Y. Vincent, Annika L. Gustafson, Michael J. Oliphant, Varsha Sreekanth, Vadym Zaberezhnyy, James C. Costello, Paul Jedlicka, Heide L. Ford
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-19 (2023)
Abstract Ewing sarcoma (ES), which is characterized by the presence of oncogenic fusion proteins such as EWS/FLI1, is an aggressive pediatric malignancy with a high rate of early dissemination and poor outcome after distant spread. Here we demonstrat
Externí odkaz:
https://doaj.org/article/ee87edcfee7141c997bb753eb3383753
Publikováno v:
Frontiers in Molecular Biosciences, Vol 7 (2020)
With the exception of non-melanoma skin cancer, breast cancer is the most frequently diagnosed malignant disease among women, with the majority of mortality being attributable to metastatic disease. Thus, even with improved early screening and more t
Externí odkaz:
https://doaj.org/article/25bac8e1d8cf4d519eed988ada5c6628
Autor:
Deguang Kong, Connor J. Hughes, Hengbo Zhou, Michael T. Lewis, Ramakrishnan R. Srinivasan, Deepika Neelakantan, Jessica Y. Hsu, Heide L. Ford
Publikováno v:
Oncogene
It is well established that a subset of cells within primary breast cancers can undergo an epithelial-to-mesenchymal transition (EMT), although the role of EMT in metastasis remains controversial. We previously demonstrated that breast cancer cells t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f60b8c987d5228a77e3696d7a6d738d6
https://doi.org/10.1038/s41388-020-01539-x
https://doi.org/10.1038/s41388-020-01539-x
Autor:
Connor J. Hughes, Rebecca Mallo, Kaiah Fields, Hengbo Zhou, Annika Gustafson, Deguang Kong, Jill Slansky, Rui Zhao, Heide L. Ford
Publikováno v:
Cancer Research. 82:2440-2440
Triple Negative Breast Cancer (TNBC), characterized by low/absent expression of the estrogen receptor and the HER2 growth factor receptor, has high rates of metastasis and an overall poor prognosis largely due to a lack of targeted therapeutic option
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e1fb13be6ab2bbc97650a5449048a0ff
https://doi.org/10.1158/1538-7445.am2022-2440
https://doi.org/10.1158/1538-7445.am2022-2440
Autor:
Miriam D. Post, Kian Behbakht, Connor J. Hughes, Alexandra McMellen, Hyunmin Kim, Tomomi M. Yamamoto, Benjamin G. Bitler, Zachary L. Watson, Lindsay J. Wheeler
Publikováno v:
Clinical Epigenetics
BackgroundEuchromatic histone-lysine-N-methyltransferases 1 and 2 (EHMT1/2, aka GLP/G9A) catalyze dimethylation of histone H3 lysine 9 (H3K9me2) and have roles in epigenetic silencing of gene expression. EHMT1/2 also have direct roles in DNA repair a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::156064d23c2fdb0490bfa091fb2cc926
http://europepmc.org/articles/PMC6882350
http://europepmc.org/articles/PMC6882350
Autor:
Lindsay J. Wheeler, Connor J. Hughes, Tomomi M. Yamamoto, Zachary L. Watson, Benjamin G. Bitler, Kian Behbakht, Miriam D. Post
Publikováno v:
Clinical Cancer Research. 26:A77-A77
The purpose of this study is to examine the contribution of epigenetics to PARP inhibitor (PARPi) resistance in high-grade serous ovarian carcinoma (HGSOC). To identify epigenetic mechanisms of PARPi resistance in HGSOC we utilized unbiased explorato
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8358a8e28d6b7f05f8fe855985a2f1d2
https://doi.org/10.1158/1557-3265.ovca19-a77
https://doi.org/10.1158/1557-3265.ovca19-a77
Autor:
Heide L. Ford, Hengbo Zhou, Rui Zhao, Michael T. Lewis, Connor J. Hughes, Juan J. Marugan, Samarijit Patnaik, Deepika Neelakantan, Deguang Kong
Publikováno v:
The FASEB Journal. 34:1-1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1f02bbec2446cefe0db33c6718711907
https://doi.org/10.1096/fasebj.2020.34.s1.00374
https://doi.org/10.1096/fasebj.2020.34.s1.00374