Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Connor J. Balzer"'
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
Arp2/3 complex nucleates branched actin filaments, and is inactive in the absense of activators. Here the authors present a model of Arp2/3 autoinhibition, whereby the Arp3 C-terminal tail acts as a structural switch that blocks movement of Arp2 and
Externí odkaz:
https://doaj.org/article/97cf8488cd504c99852d793a6ab1a5c9
Autor:
Connor J Balzer, Michael L James, Heidy Y Narvaez-Ortiz, Luke A Helgeson, Vladimir Sirotkin, Brad J Nolen
Publikováno v:
eLife, Vol 9 (2020)
The actin filament nucleator Arp2/3 complex is activated at cortical sites in Schizosaccharomyces pombe to assemble branched actin networks that drive endocytosis. Arp2/3 complex activators Wsp1 and Dip1 are required for proper actin assembly at endo
Externí odkaz:
https://doaj.org/article/823e4f2003f4485ca5f1b732859c53b3
The actin filament nucleator Arp2/3 complex is activated at cortical sites inS. pombeto assemble branched actin networks that drive endocytosis. Arp2/3 complex activators Wsp1 and Dip1 are required for proper actin assembly at endocytic sites, but ho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::993e2ea986dc72077adfcad085ef9d52
https://doi.org/10.1101/2020.07.03.187120
https://doi.org/10.1101/2020.07.03.187120
Publikováno v:
Current biology : CB. 28(23)
Summary When activated by Wiskott-Aldrich syndrome proteins (WASP), Arp2/3 complex nucleates branched actin filaments important for processes like cellular motility and endocytosis [ 1 ]. WASP-mediated activation of Arp2/3 complex requires a preforme
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa97152946ad0f63646c66800c342c92
https://pubmed.ncbi.nlm.nih.gov/30471998
https://pubmed.ncbi.nlm.nih.gov/30471998
Publikováno v:
Curr Biol
Summary Arp2/3 complex nucleates branched actin filaments important for cellular motility, endocytosis, meiosis, and cellular differentiation [ 1 , 2 , 3 , 4 ]. Wiskott-Aldrich syndrome proteins (WASPs), the prototypical Arp2/3 complex activators, ac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9155941606aca9fc8c66161762ad148
https://doi.org/10.1016/j.cub.2019.08.023
https://doi.org/10.1016/j.cub.2019.08.023
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
Nature Communications
Nature Communications
Nucleation of branched actin filaments by Arp2/3 complex is tightly regulated to control actin assembly in cells. Arp2/3 complex activation involves conformational changes brought about by ATP, Nucleation Promoting Factor (NPF) proteins, actin filame
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::869ebf8cc4e6b93b46e986fd321ec3a9
https://doi.org/10.1038/ncomms12226
https://doi.org/10.1038/ncomms12226