Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Connor E. Rosen"'
Autor:
Gunjan Arora, Geoffrey E. Lynn, Xiaotian Tang, Connor E. Rosen, Dieuwertje Hoornstra, Andaleeb Sajid, Joppe W. Hovius, Noah W. Palm, Aaron M. Ring, Erol Fikrig
Publikováno v:
mBio, Vol 13, Iss 5 (2022)
ABSTRACT Relapsing fever, caused by diverse Borrelia spirochetes, is prevalent in many parts of the world and causes significant morbidity and mortality. To investigate the pathoetiology of relapsing fever, we performed a high-throughput screen of Bo
Externí odkaz:
https://doaj.org/article/35d05fb513464987a78adb7dc44c4293
Autor:
Eric Y. Wang, Yile Dai, Connor E. Rosen, Monica M. Schmitt, Mei X. Dong, Elise M.N. Ferré, Feimei Liu, Yi Yang, Jaime A. González-Hernández, Eric Meffre, Monique Hinchcliff, Fotios Koumpouras, Michail S. Lionakis, Aaron M. Ring
Publikováno v:
Cell reports methods. 2(2)
Autoantibodies that recognize extracellular proteins (the exoproteome) exert potent biological effects but are challenging to detect. Here, we developed rapid extracellular antigen profiling (REAP), a high-throughput technique for the comprehensive d
Autor:
Jun Wang, K. Patricia Hartmann, Connor E. Rosen, Richard A. Flavell, Marcus Bosenberg, Suzanne Fischer, Orr-El Weizman, Ruaidhri Jackson, Aaron M. Ring, Ting Zhou, William Damsky, Miguel F. Sanmamed, Meaghan K. McGeary
Publikováno v:
Nature
Cytokines were the first modern immunotherapies to produce durable responses in patients with advanced cancer, but they have only modest efficacy and limited tolerability1,2. In an effort to identify alternative cytokine pathways for immunotherapy, w
Autoinhibition of Bruton's tyrosine kinase (Btk) and activation by soluble inositol hexakisphosphate
Autor:
Qi Wang, Erik M Vogan, Laura M Nocka, Connor E Rosen, Julie A Zorn, Stephen C Harrison, John Kuriyan
Publikováno v:
eLife, Vol 4 (2015)
Bruton's tyrosine kinase (Btk), a Tec-family tyrosine kinase, is essential for B-cell function. We present crystallographic and biochemical analyses of Btk, which together reveal molecular details of its autoinhibition and activation. Autoinhibited B
Externí odkaz:
https://doaj.org/article/8e8d6a00ebf74762849d3409c8279eda
Autor:
Tyler A. Rice, Agata A. Bielecka, Mytien T. Nguyen, Connor E. Rosen, Deguang Song, Nicole D. Sonnert, Yi Yang, Yiyun Cao, Varnica Khetrapal, Jason R. Catanzaro, Anjelica L. Martin, Saleh A. Rashed, Shana R. Leopold, Liming Hao, Xuezhu Yu, David van Dijk, Aaron M. Ring, Richard A. Flavell, Marcel R. de Zoete, Noah W. Palm
Publikováno v:
Cell Host & Microbe. 30:988-1002.e6
The impacts of individual commensal microbes on immunity and disease can differ dramatically depending on the surrounding microbial context; however, the specific bacterial combinations that dictate divergent immunological outcomes remain largely und
Autor:
Klein D, Srikantan S. Nagarajan, Schneider S, Garrett C, Honma S, Bhutada A, Kamalini G. Ranasinghe, Sen-ching S. Cheung, Hardik Kothare, Katherine C. Yung, Connor E. Rosen, Leighton B. Hinkley, Mark S. Courey, Houde J, Naunheim M, Danielle Mizuiri
Laryngeal Dystonia is a debilitating disorder of voicing in which the laryngeal muscles are intermittently in spasm resulting in involuntary interruptions during speech. The central pathophysiology of laryngeal dystonia, underlying computational impa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7b7529c9901a3a254993b004ebd37a1a
https://doi.org/10.1101/2021.04.08.438908
https://doi.org/10.1101/2021.04.08.438908
Autor:
Michail S. Lionakis, Ferré Emn, Schmitt Mm, Eric Meffre, Eric Wang, Dong Mx, Koumpouras F, Feimei Liu, Yuchen Yang, Gonzalez-Hernandez Ja, Hinchcliffe M, Yile Dai, Aaron M. Ring, Connor E. Rosen
Autoantibodies that recognize extracellular protein epitopes (the "exoproteome") exert potent functional effects that underlie numerous disease processes. Identifying these antibodies can thus provide insights into the pathophysiology of a wide spect
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d1ca664aa28ae5c7f07482bb6ea181a3
https://doi.org/10.1101/2021.02.11.430703
https://doi.org/10.1101/2021.02.11.430703
Autor:
Connor E. Rosen, Gunjan Arora, Yu Min Chuang, Utpal Pal, Aaron M. Ring, Erol Fikrig, Yongguo Cao, Sukanya Narasimhan, Xiaotian Tang, Carmen J. Booth, Kristen E. Murfin, Jiri Cerny, Alejandro Marin Lopez, Akash Gupta
Publikováno v:
Infection and Immunity
Borrelia burgdorferi causes Lyme disease, the most common tick-transmitted illness in North America. When Ixodes scapularis feed on an infected vertebrate host, spirochetes enter the tick gut along with the bloodmeal and colonize the vector. Here, we
Autor:
Akash Gupta, Noah W. Palm, Zachary A. Kloos, Maryna Golovchenko, Ulrike G. Munderloh, Aaron M. Ring, Connor E. Rosen, Jiri Cerny, Natalie Rudenko, Christine Jacobs-Wagner, Erol Fikrig, Carmen J. Booth, Gunjan Arora, Andaleeb Sajid, Yongguo Cao, Dieuwertje Hoornstra, Joppe W. Hovius
Publikováno v:
PLoS pathogens, 16(11):e1009030. Public Library of Science
PLoS Pathogens
PLoS Pathogens, Vol 16, Iss 11, p e1009030 (2020)
PLoS Pathogens
PLoS Pathogens, Vol 16, Iss 11, p e1009030 (2020)
Lyme disease, the most common vector-borne illness in North America, is caused by the spirochete Borrelia burgdorferi. Infection begins in the skin following a tick bite and can spread to the hearts, joints, nervous system, and other organs. Diverse
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c468f10a9c594ee7f142c1cdcf9c776c
https://pure.amc.nl/en/publications/a-human-secretome-library-screen-reveals-a-role-for-peptidoglycan-recognition-protein-1-in-lyme-borreliosis(d10808ff-6456-499b-ba41-605064f77d11).html
https://pure.amc.nl/en/publications/a-human-secretome-library-screen-reveals-a-role-for-peptidoglycan-recognition-protein-1-in-lyme-borreliosis(d10808ff-6456-499b-ba41-605064f77d11).html
Autor:
Noah W. Palm, Connor E. Rosen
Publikováno v:
Cell Host & Microbe. 23:1-3
Identifying members of the intestinal microbiota that play causal roles in shaping human disease susceptibility has been an ongoing challenge. In their recent paper in Nature, Surana and Kasper (2017) present a new strategy that may help "triangulate