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pro vyhledávání: '"Connor B Cribb"'
Autor:
Ian S. Barton, Zhongqing Ren, Connor B. Cribb, Joshua E. Pitzer, Ilaria Baglivo, Daniel W. Martin, Xindan Wang, R. Martin Roop
Publikováno v:
mBio, Vol 14, Iss 6 (2023)
ABSTRACTHistone-like nucleoid structuring (H-NS) and H-NS-like proteins serve as global gene silencers and work with antagonistic transcriptional activators (counter-silencers) to properly coordinate the expression of virulence genes in pathogenic ba
Externí odkaz:
https://doaj.org/article/6cb25274efeb4471aca7f74ea8cca5cd
Autor:
Manoj Chelvanambi, Matthew Powell, Connor B Cribb, Donald P. McDonnell, Rigel J. Kishton, Phat T Do, Leah L Lowder, Sridhar Varadarajan, Kelly Mastro-Kishton, Giridhar R. Akkaraju, Sean E. Miller, Libero J. Bartolotti, Suzanne E. Wardell, Charles B. Kelly, Rajeshwar Reddy Govindapur, Arthur R. Frampton
Publikováno v:
Journal of Medicinal Chemistry. 64:12651-12669
We previously described the development of a DNA-alkylating compound that showed selective toxicity in breast cancer cells. This compound contained an estrogen receptor α (ERα)-binding ligand and a DNA-binding/methylating component that could selec