Zobrazeno 1 - 10
of 151
pro vyhledávání: '"Connor A, Emdin"'
Autor:
Mary E. Haas, James P. Pirruccello, Samuel N. Friedman, Minxian Wang, Connor A. Emdin, Veeral H. Ajmera, Tracey G. Simon, Julian R. Homburger, Xiuqing Guo, Matthew Budoff, Kathleen E. Corey, Alicia Y. Zhou, Anthony Philippakis, Patrick T. Ellinor, Rohit Loomba, Puneet Batra, Amit V. Khera
Publikováno v:
Cell Genomics, Vol 1, Iss 3, Pp 100066- (2021)
Summary: Excess liver fat, called hepatic steatosis, is a leading risk factor for end-stage liver disease and cardiometabolic diseases but often remains undiagnosed in clinical practice because of the need for direct imaging assessments. We developed
Externí odkaz:
https://doaj.org/article/ce0ff6a4ad504e1ea29d8ed0ca8dce9a
Autor:
Nooshin Ghodsian, Erik Abner, Connor A. Emdin, Émilie Gobeil, Nele Taba, Mary E. Haas, Nicolas Perrot, Hasanga D. Manikpurage, Éloi Gagnon, Jérôme Bourgault, Alexis St-Amand, Christian Couture, Patricia L. Mitchell, Yohan Bossé, Patrick Mathieu, Marie-Claude Vohl, André Tchernof, Sébastien Thériault, Amit V. Khera, Tõnu Esko, Benoit J. Arsenault
Publikováno v:
Cell Reports Medicine, Vol 2, Iss 11, Pp 100437- (2021)
Summary: Non-alcoholic fatty liver disease (NAFLD) is a complex disease linked to several chronic diseases. We aimed at identifying genetic variants associated with NAFLD and evaluating their functional consequences. We performed a genome-wide meta-a
Externí odkaz:
https://doaj.org/article/19e306941a06424da1e769a90f8e839d
Autor:
Chris B. Stone, David C. Bulir, Connor A. Emdin, Ryan M. Pirie, Elisa A. Porfilio, Jerry W. Slootstra, James B. Mahony
Publikováno v:
Frontiers in Microbiology, Vol 12 (2021)
Externí odkaz:
https://doaj.org/article/cb8f564ca96a498382275efa1268f52c
Autor:
Connor A Emdin, Mary E Haas, Amit V Khera, Krishna Aragam, Mark Chaffin, Derek Klarin, George Hindy, Lan Jiang, Wei-Qi Wei, Qiping Feng, Juha Karjalainen, Aki Havulinna, Tuomo Kiiskinen, Alexander Bick, Diego Ardissino, James G Wilson, Heribert Schunkert, Ruth McPherson, Hugh Watkins, Roberto Elosua, Matthew J Bown, Nilesh J Samani, Usman Baber, Jeanette Erdmann, Namrata Gupta, John Danesh, Danish Saleheen, Kyong-Mi Chang, Marijana Vujkovic, Ben Voight, Scott Damrauer, Julie Lynch, David Kaplan, Marina Serper, Philip Tsao, Million Veteran Program, Josep Mercader, Craig Hanis, Mark Daly, Joshua Denny, Stacey Gabriel, Sekar Kathiresan
Publikováno v:
PLoS Genetics, Vol 17, Iss 4, p e1009503 (2021)
[This corrects the article DOI: 10.1371/journal.pgen.1008629.].
Externí odkaz:
https://doaj.org/article/78e34e0716754e149bfe3845606b06c3
Autor:
Connor A Emdin, Mary E Haas, Amit V Khera, Krishna Aragam, Mark Chaffin, Derek Klarin, George Hindy, Lan Jiang, Wei-Qi Wei, Qiping Feng, Juha Karjalainen, Aki Havulinna, Tuomo Kiiskinen, Alexander Bick, Diego Ardissino, James G Wilson, Heribert Schunkert, Ruth McPherson, Hugh Watkins, Roberto Elosua, Matthew J Bown, Nilesh J Samani, Usman Baber, Jeanette Erdmann, Namrata Gupta, John Danesh, Danish Saleheen, Kyong-Mi Chang, Marijana Vujkovic, Ben Voight, Scott Damrauer, Julie Lynch, David Kaplan, Marina Serper, Philip Tsao, Million Veteran Program, Josep Mercader, Craig Hanis, Mark Daly, Joshua Denny, Stacey Gabriel, Sekar Kathiresan
Publikováno v:
PLoS Genetics, Vol 16, Iss 4, p e1008629 (2020)
Analyzing 12,361 all-cause cirrhosis cases and 790,095 controls from eight cohorts, we identify a common missense variant in the Mitochondrial Amidoxime Reducing Component 1 gene (MARC1 p.A165T) that associates with protection from all-cause cirrhosi
Externí odkaz:
https://doaj.org/article/39ed03da04ee4e80b0a235596832cedb
Autor:
Viktoria Gusarova, Colm O’Dushlaine, Tanya M. Teslovich, Peter N. Benotti, Tooraj Mirshahi, Omri Gottesman, Cristopher V. Van Hout, Michael F. Murray, Anubha Mahajan, Jonas B. Nielsen, Lars Fritsche, Anders Berg Wulff, Daniel F. Gudbjartsson, Marketa Sjögren, Connor A. Emdin, Robert A. Scott, Wen-Jane Lee, Aeron Small, Lydia C. Kwee, Om Prakash Dwivedi, Rashmi B. Prasad, Shannon Bruse, Alexander E. Lopez, John Penn, Anthony Marcketta, Joseph B. Leader, Christopher D. Still, H. Lester Kirchner, Uyenlinh L. Mirshahi, Amr H. Wardeh, Cassandra M. Hartle, Lukas Habegger, Samantha N. Fetterolf, Teresa Tusie-Luna, Andrew P. Morris, Hilma Holm, Valgerdur Steinthorsdottir, Patrick Sulem, Unnur Thorsteinsdottir, Jerome I. Rotter, Lee-Ming Chuang, Scott Damrauer, David Birtwell, Chad M. Brummett, Amit V. Khera, Pradeep Natarajan, Marju Orho-Melander, Jason Flannick, Luca A. Lotta, Cristen J. Willer, Oddgeir L. Holmen, Marylyn D. Ritchie, David H. Ledbetter, Andrew J. Murphy, Ingrid B. Borecki, Jeffrey G. Reid, John D. Overton, Ola Hansson, Leif Groop, Svati H. Shah, William E. Kraus, Daniel J. Rader, Yii-Der I. Chen, Kristian Hveem, Nicholas J. Wareham, Sekar Kathiresan, Olle Melander, Kari Stefansson, Børge G. Nordestgaard, Anne Tybjærg-Hansen, Goncalo R. Abecasis, David Altshuler, Jose C. Florez, Michael Boehnke, Mark I. McCarthy, George D. Yancopoulos, David J. Carey, Alan R. Shuldiner, Aris Baras, Frederick E. Dewey, Jesper Gromada
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
Genetic variation in ANGPTL4 is associated with lipid traits. Here, the authors find that predicted loss-of-function variants in ANGPTL4 are associated with glucose homeostasis and reduced risk of type 2 diabetes and that Angptl4 −/− mice on a hi
Externí odkaz:
https://doaj.org/article/a3d832a109514250b3a42f9eaa1a1b95
Autor:
Connor A. Emdin, Amit V. Khera, Mark Chaffin, Derek Klarin, Pradeep Natarajan, Krishna Aragam, Mary Haas, Alexander Bick, Seyedeh M. Zekavat, Akihiro Nomura, Diego Ardissino, James G. Wilson, Heribert Schunkert, Ruth McPherson, Hugh Watkins, Roberto Elosua, Matthew J. Bown, Nilesh J. Samani, Usman Baber, Jeanette Erdmann, Namrata Gupta, John Danesh, Daniel Chasman, Paul Ridker, Joshua Denny, Lisa Bastarache, Judith H. Lichtman, Gail D’Onofrio, Jennifer Mattera, John A. Spertus, Wayne H.-H. Sheu, Kent D. Taylor, Bruce M. Psaty, Stephen S. Rich, Wendy Post, Jerome I. Rotter, Yii-Der Ida Chen, Harlan Krumholz, Danish Saleheen, Stacey Gabriel, Sekar Kathiresan
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-8 (2018)
Examination of predicted loss-of-function (pLOF) genetic variants allows direct identification of genes with therapeutic potential. Here, Emdin et al. perform association analysis for 3759 pLOF variants with 24 traits and highlight protective variant
Externí odkaz:
https://doaj.org/article/5b782df960c64245a2f0b6bdfadd7745
Autor:
Allan J. Hsiao, Connor A. Emdin
Publikováno v:
Journal of Epidemiology and Global Health, Vol 5, Iss 1 (2019)
Development assistance for health (DAH) and foreign aid have been criticized for being poorly associated with health and economic outcomes on a national level. This study is an attempt to examine whether DAH targeted specifically to malaria, HIV and
Externí odkaz:
https://doaj.org/article/13ff9428da3b494d8c796f1cece4c23b
Autor:
Connor A, Emdin, Rui, Xia, Saaket, Agrawal, Jamal S, Rana, Donald, Lloyd-Jones, Myriam, Fornage, Amit V, Khera
Publikováno v:
Journal of the American College of Cardiology. 80:280-282
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b3a3c396c4fd3610872d3ef44fe161f
https://doi.org/10.1016/j.jacc.2022.05.013
https://doi.org/10.1016/j.jacc.2022.05.013
Autor:
Amit V. Khera, Minxian Wang, Mark Chaffin, Connor A. Emdin, Nilesh J. Samani, Heribert Schunkert, Hugh Watkins, Ruth McPherson, Jeanette Erdmann, Roberto Elosua, Eric Boerwinkle, Diego Ardissino, Adam S. Butterworth, Emanuele Di Angelantonio, Aliya Naheed, John Danesh, Rajiv Chowdhury, Harlan M. Krumholz, Wayne H.-H. Sheu, Stephen S. Rich, Jerome I. Rotter, Yii-der Ida Chen, Stacey Gabriel, Eric S. Lander, Danish Saleheen, Sekar Kathiresan
Publikováno v:
Circulation. Genomic and precision medicine. 15(6)
Background: A key goal of precision medicine is to disaggregate common, complex diseases into discrete molecular subtypes. Rare coding variants in the low-density lipoprotein receptor gene ( LDLR ) are identified in 1% to 2% of coronary artery diseas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11cb62395dd92e6281910ae91745769f
https://pubmed.ncbi.nlm.nih.gov/36215124
https://pubmed.ncbi.nlm.nih.gov/36215124