CpG-free plasmid expression cassettes for cystic fibrosis gene therapy

Autor: Pringle, Ian A., Hyde, Stephen C., Connolly, Mary M., Lawton, Anna E., Xu, Bihui, Nunez-Alonso, Graciela, Davies, Lee A., Sumner-Jones, Stephanie G., Gill, Deborah R.

Publikováno v: In Biomaterials October 2012 33(28):6833-6842

Preparation for a first-in-man lentivirus trial in patients with cystic fibrosis

Autor: Alton, Eric WFW, Beekman, Jeffery M, Boyd, A Christopher, Brand, June, Carlon, Marianne, Connolly, Mary M, Chan, Mario, Conlon, Sinead, Davidson, Heather E, Davies, Jane C, Davies, Lee A, Dekkers, Johanna F, Doherty, Ann, Gea-Sorli, Sabrina, Gill, Deborah R, Griesenbach, Uta, Hasegawa, Mamoru, Higgins, Tracy E, Hironaka, Takashi, Hyndman, Laura, McLachlan, Gerry, Inoue, Makoto, Hyde, Stephen C, Innes, J Alastair, Maher, Toby M, Moran, Caroline, Meng, Cuixiang, Paul-Smith, Michael C, Pringle, Ian A, Pytel, Kamila M, Rodriguez-Martinez, Andrea, Schmidt, Alexander C, Stevenson, Barbara J, Sumner-Jones, Stephanie G, Toshner, Richard, Tsugumine, Shu, Wasowicz, Marguerite W, Zhu, Jie

Publikováno v: Alton, E WFW, Beekman, J M, Boyd, A C, Brand, J, Carlon, M S, Connolly, M M, Chan, M, Conlon, S, Davidson, H, Davies, J C, Davies, L A, Dekkers, J F, Doherty, A, Gea-sorli, S, Gill, D R, Griesenbach, U, Hasegawa, M, Higgins, T E, Hironaka, T, Hyndman, L, McLachlan, G, Inoue, M, Hyde, S C, Innes, J A, Maher, T M, Moran, C, Meng, C, Paul-Smith, M C, Pringle, I A, Pytel, K M, Rodriguez-Martinez, A, Schmidt, A C, Stevenson, B, Sumner-Jones, S G, Toshner, R, Tsugumine, S, Wasowicz, M W & Zhu, J 2017, ' Preparation for a first-in-man lentivirus trial in patients with cystic fibrosis ', Thorax, vol. 72, no. 2, pp. 137-147 . https://doi.org/10.1136/thoraxjnl-2016-208406
Thorax

We have recently shown that non-viral gene therapy can stabilise the decline of lung function in patients with cystic fibrosis (CF). However, the effect was modest, and more potent gene transfer agents are still required. Fuson protein (F)/Hemaggluti

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https://ora.ox.ac.uk/objects/uuid:06e16f3b-e8eb-4ccb-b37f-5e85a5a75530

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Viral sequence determines HLA-E-restricted T cell recognition of hepatitis B surface antigen.

Autor: Murugesan G; Immunocore Ltd, 92 Park Drive, Abingdon, Oxfordshire, OX14 4RY, UK., Paterson RL; Immunocore Ltd, 92 Park Drive, Abingdon, Oxfordshire, OX14 4RY, UK., Kulkarni R; Immunocore Ltd, 92 Park Drive, Abingdon, Oxfordshire, OX14 4RY, UK., Ilkow V; Immunocore Ltd, 92 Park Drive, Abingdon, Oxfordshire, OX14 4RY, UK., Suckling RJ; Immunocore Ltd, 92 Park Drive, Abingdon, Oxfordshire, OX14 4RY, UK., Connolly MM; Immunocore Ltd, 92 Park Drive, Abingdon, Oxfordshire, OX14 4RY, UK., Karuppiah V; Immunocore Ltd, 92 Park Drive, Abingdon, Oxfordshire, OX14 4RY, UK., Pengelly R; Immunocore Ltd, 92 Park Drive, Abingdon, Oxfordshire, OX14 4RY, UK., Jadhav A; Immunocore Ltd, 92 Park Drive, Abingdon, Oxfordshire, OX14 4RY, UK., Donoso J; Immunocore Ltd, 92 Park Drive, Abingdon, Oxfordshire, OX14 4RY, UK., Heunis T; Immunocore Ltd, 92 Park Drive, Abingdon, Oxfordshire, OX14 4RY, UK., Bunjobpol W; Immunocore Ltd, 92 Park Drive, Abingdon, Oxfordshire, OX14 4RY, UK., Philips G; Immunocore Ltd, 92 Park Drive, Abingdon, Oxfordshire, OX14 4RY, UK., Ololade K; Immunocore Ltd, 92 Park Drive, Abingdon, Oxfordshire, OX14 4RY, UK., Kay D; Immunocore Ltd, 92 Park Drive, Abingdon, Oxfordshire, OX14 4RY, UK., Sarkar A; Immunocore Ltd, 92 Park Drive, Abingdon, Oxfordshire, OX14 4RY, UK., Barber C; Immunocore Ltd, 92 Park Drive, Abingdon, Oxfordshire, OX14 4RY, UK., Raj R; Immunocore Ltd, 92 Park Drive, Abingdon, Oxfordshire, OX14 4RY, UK., Perot C; Immunocore Ltd, 92 Park Drive, Abingdon, Oxfordshire, OX14 4RY, UK., Grant T; Immunocore Ltd, 92 Park Drive, Abingdon, Oxfordshire, OX14 4RY, UK., Treveil A; Immunocore Ltd, 92 Park Drive, Abingdon, Oxfordshire, OX14 4RY, UK., Walker A; Immunocore Ltd, 92 Park Drive, Abingdon, Oxfordshire, OX14 4RY, UK., Dembek M; Immunocore Ltd, 92 Park Drive, Abingdon, Oxfordshire, OX14 4RY, UK., Gibbs-Howe D; Immunocore Ltd, 92 Park Drive, Abingdon, Oxfordshire, OX14 4RY, UK., Hock M; Immunocore Ltd, 92 Park Drive, Abingdon, Oxfordshire, OX14 4RY, UK., Carreira RJ; Immunocore Ltd, 92 Park Drive, Abingdon, Oxfordshire, OX14 4RY, UK., Atkin KE; Immunocore Ltd, 92 Park Drive, Abingdon, Oxfordshire, OX14 4RY, UK., Dorrell L; Immunocore Ltd, 92 Park Drive, Abingdon, Oxfordshire, OX14 4RY, UK., Knox A; Immunocore Ltd, 92 Park Drive, Abingdon, Oxfordshire, OX14 4RY, UK., Leonard S; Immunocore Ltd, 92 Park Drive, Abingdon, Oxfordshire, OX14 4RY, UK., Salio M; Immunocore Ltd, 92 Park Drive, Abingdon, Oxfordshire, OX14 4RY, UK., Godinho LF; Immunocore Ltd, 92 Park Drive, Abingdon, Oxfordshire, OX14 4RY, UK. luis.godinho@immunocore.com.

Publikováno v: Nature communications [Nat Commun] 2024 Nov 22; Vol. 15 (1), pp. 10126. Date of Electronic Publication: 2024 Nov 22.