Výsledky vyhledávání - "Connie S Zhang"

Monitoring the stabilities of a mixture of peptides by mass-spectrometry-based techniques

Autor: Connie S Zhang, Zhichao Zhang, David A. Hales, Kameron R Molloy, Tarick J. El-Baba, Daniel R. Fuller, Christopher R. Conant, David E. Clemmer

Publikováno v: Eur J Mass Spectrom (Chichester)

Biomolecular degradation plays a key role in proteostasis. Typically, proteolytic enzymes degrade proteins into smaller peptides by breaking amino acid bonds between specific residues. Cleavage around proline residues is often missed and requires hig

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ec3806ee160a27ab8129114ca8bf81b
https://europepmc.org/articles/PMC7702224/

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Interleukin-4 Expressed By Neoplastic Cells Provokes an Anti-Metastatic Myeloid Immune Response

Autor: Connie S, Zhang, Hyeyeon, Kim, Graeme, Mullins, Kathrin, Tyryshkin, David P, LeBrun, Bruce E, Elliott, Peter A, Greer

Publikováno v: Journal of clinical & cellular immunology

Objective Interleukin-4 (IL-4) can induce macrophages to undergo alternative activation and polarize toward an M2-like or wound healing phenotype. Tumor associated macrophages (TAMs) are thought to assume M2-like properties, and it has been suggested

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::539a0c68f1d1ec8fa07e6de8859c180a
https://pubmed.ncbi.nlm.nih.gov/27563494

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Interleukin-4 Expressed By Neoplastic Cells Provokes an Anti-Metastatic Myeloid Immune Response

Autor: Kathrin Tyryshkin, Peter A. Greer, Bruce E. Elliott, Hyeyeon Kim, David P. LeBrun, Connie S. Zhang, Graeme Mullins

Publikováno v: Journal of Clinical & Cellular Immunology.

Objective: Interleukin-4 (IL-4) can induce macrophages to undergo alternative activation and polarize toward an M2-like or wound healing phenotype. Tumor associated macrophages (TAMs) are thought to assume M2-like properties, and it has been suggeste

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1a2809ffad109ac018fa9e5735cc513e
https://doi.org/10.4172/2155-9899.1000329

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Abstract 2230: Evaluation of PD-L1 expression in ovarian carcinosarcoma by immunohistochemistry and RNAscope in-situ hybridization

Autor: Xiao-Jun Ma, Li Liang, Jun Song Chen, Emily Park, Jinsong Liu, Na Niu, Connie S. Zhang, Yi Jiang

Publikováno v: Cancer Research. 76:2230-2230

Ovarian carcinosarcoma, also called malignant Müllerian mixed tumor, is a rare, but very aggressive biphasic tumor with both malignant epithelial and stromal components. PD-L1 is one of the ligands of immune inhibitory receptor PD-1. PD-L1/PD-1 path

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6a9816ab0da969b626ef1077ab4f4a5c
https://doi.org/10.1158/1538-7445.am2016-2230

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Abstract B05: An immune modulatory role for the Fes protein tyrosine kinase

Autor: Sam Basta, Faizah Mesfer Alotaibi, Peter A. Greer, Connie S. Zhang

Publikováno v: Molecular Cancer Therapeutics. 14:B05-B05

The Fes protein tyrosine kinase is abundantly expressed in phagocytic immune cells, including tumor associated macrophages. In addition to the C-terminal kinase and central SH2 domains, Fes contains an N-terminal F-BAR domain that confers unique memb

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::899b5b37fab2ea565daef97a8d02baa5
https://doi.org/10.1158/1538-8514.tumang15-b05

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Abstract B098: Tumor cell-derived IL-4 suppresses tumor growth and metastasis

Autor: Peter A. Greer, Connie S. Zhang

Publikováno v: Molecular Cancer Research. 11:B098-B098

Interleukin 4 (IL-4) is a cytokine that, among other actions, can induce macrophages to undergo alternative activation and polarize to M2 macrophages which have been reported to promote tumorigenesis and metastasis. IL-4 also promotes the formation o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5f1a69b6ea719f269e1e727c09951d42
https://doi.org/10.1158/1557-3125.advbc-b098

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Abstract A076: Deficiency of Fes tyrosine kinase expression correlates with delayed mammary tumor onset in a HER2/Neu overexpressing transgenic mouse model

Autor: Peter A. Greer, Connie S. Zhang

Publikováno v: Molecular Cancer Research. 11:A076-A076

Fes (a.k.a. Fps) is a cytoplasmic protein tyrosine kinase that is highly expressed in breast epithelial cells during lactation, as well as in vascular endothelial and myeloid cells. Retrovirally encoded oncogenic alleles of Fes are associated with tu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::dcfc417e8891b2e97cad697b699e1e59
https://doi.org/10.1158/1557-3125.advbc-a076

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Abstract 1405: Deficiency of Fes tyrosine kinase expression correlates with delayed mammary tumor onset in a HER2/Neu over-expressing transgenic mouse model

Autor: Connie S. Zhang, Peter A. Greer

Publikováno v: Cancer Research. 73:1405-1405

Fes (a.k.a. Fps) is a cytoplasmic protein tyrosine kinase that is highly expressed in breast epithelial cells during lactation, as well as in vascular endothelial and myeloid cells. Retrovially encoded oncogenic alleles of Fes are associated with tum

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3296d4fca413b6b0c283ff076c7f1e0c
https://doi.org/10.1158/1538-7445.am2013-1405

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