Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Connie S, Lebakken"'
Human induced pluripotent stem cell-derived planar neural organoids assembled on synthetic hydrogels
Autor:
Joydeb Majumder, Elizabeth E Torr, Elizabeth A Aisenbrey, Connie S Lebakken, Peter F Favreau, William D Richards, Yanhong Yin, Qiang Chang, William L Murphy
Publikováno v:
Journal of Tissue Engineering, Vol 15 (2024)
The tailorable properties of synthetic polyethylene glycol (PEG) hydrogels make them an attractive substrate for human organoid assembly. Here, we formed human neural organoids from iPSC-derived progenitor cells in two distinct formats: (i) cells see
Externí odkaz:
https://doaj.org/article/86c87a2ea4184847a73652280ca741fb
Autor:
April eReynolds, Elizabeth A Doggett, Steven M. Riddle, Connie S Lebakken, R. Jeremy eNichols
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 7 (2014)
Missense mutations in the Leucine Rich Repeat protein Kinase 2 (LRRK2) gene are the most common genetic predisposition to develop Parkinson’s disease (PD) LRRK2 is a large multi-domain phosphoprotein with a GTPase domain and a serine/threonine prot
Externí odkaz:
https://doaj.org/article/0543250f3c224abd8e3c570750af358a
Endothelial cells (ECs) play a major role in blood vessel formation and function. While there is longstanding evidence for the potential of chemical exposures to adversely affect EC function and vascular development, the hazard potential of chemicals
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ce1bd1709f1ddec08e9c1169e1ad443
https://europepmc.org/articles/PMC5576216/
https://europepmc.org/articles/PMC5576216/
Versatile synthetic alternatives to Matrigel for vascular toxicity screening and stem cell expansion
Autor:
Mohammad Ali Saghiri, Connie S. Lebakken, David G. Belair, Mitra Farnoodian, Ngoc Nhi Le, Thomas B. Knudsen, William L. Murphy, Gene E. Ananiev, Eric H. Nguyen, William T. Daly, Nader Sheibani, Michael P. Schwartz
Publikováno v:
Nature biomedical engineering
The physiological relevance of Matrigel as a cell-culture substrate and in angiogenesis assays is often called into question. Here, we describe an array-based method for the identification of synthetic hydrogels that promote the formation of robust i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::189acf90f06c8f95c2e92db43c91b10d
https://doi.org/10.1038/s41551-017-0096
https://doi.org/10.1038/s41551-017-0096
Publikováno v:
SLAS Discovery. 17:813-821
Non-adenosine triphosphate (ATP) competitive, allosteric inhibitors provide a promising avenue to develop highly selective small-molecule kinase inhibitors. Although this class of compounds is growing, detection of such inhibitors can be challenging
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::baffe0cfd7378bf40fac0b7f3eac2794
https://doi.org/10.1177/1087057112439889
https://doi.org/10.1177/1087057112439889
Publikováno v:
Expert Opinion on Drug Discovery. 6:701-712
Over the past decade, there has been an increased number of FDA approved small molecule kinase inhibitors for the treatment of cancer. This is due, in part, to an increased understanding of the fundamental aspects of kinase biology, coupled with adva
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b43f8f7411ce8b8a4c23f9ca51d956c2
https://doi.org/10.1517/17460441.2011.575776
https://doi.org/10.1517/17460441.2011.575776
Autor:
Jeffrey E. Pessin, Kevin P. Campbell, Matthew M. Goddeeris, David Venzke, Haihong Zong, Séverine Groh, Connie S. Lebakken
Publikováno v:
Journal of Biological Chemistry. 284:19178-19182
The sarcoglycans are known as an integral subcomplex of the dystrophin glycoprotein complex, the function of which is best characterized in skeletal muscle in relation to muscular dystrophies. Here we demonstrate that the white adipocytes, which shar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dd150a4fab9ca026763b04a5c3a12b28
https://doi.org/10.1074/jbc.c109.010728
https://doi.org/10.1074/jbc.c109.010728
Publikováno v:
SLAS Discovery. 12:828-841
The authors present a fluorescence lifetime-based kinase binding assay that identifies and characterizes compounds that bind to the adenosine triphosphate (ATP)-binding pocket of a range of tyrosine and serine/threonine kinases. The assay is based on
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ebc15cef3812a367dec3cadf7265a4d8
https://doi.org/10.1177/1087057107304480
https://doi.org/10.1177/1087057107304480
Autor:
Connie S. Lebakken, Kaitlyn Vandenheuvel-Kramer, Andrew L. Kopp, Jasmin R. Gibson, Tina M. Hallis, Tammy Turek-Etienne, Michael K. Hancock
Publikováno v:
SLAS Discovery. 12:635-644
A problem inherent to the use of cellular assays for drug discovery is their sensitivity to cytotoxic compounds, which can result in false hits from certain compound screens. To alleviate the need to follow-up hits from a reporter assay with a separa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08aad48717dd44d80a38293578cbeb2f
https://doi.org/10.1177/1087057107301499
https://doi.org/10.1177/1087057107301499
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 7 (2014)
Frontiers in Molecular Neuroscience
Frontiers in Molecular Neuroscience
Missense mutations in the Leucine-Rich Repeat protein Kinase 2 (LRRK2) gene are the most common genetic predisposition to develop Parkinson's disease (PD) (Farrer et al., 2005; Skipper et al., 2005; Di Fonzo et al., 2006; Healy et al., 2008; Paisan-R
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a5c800934052260245d0158bebd74e9
http://journal.frontiersin.org/Journal/10.3389/fnmol.2014.00054/full
http://journal.frontiersin.org/Journal/10.3389/fnmol.2014.00054/full