Zobrazeno 1 - 10
of 66
pro vyhledávání: '"Connie M. Krawczyk"'
Autor:
Hannah Guak, Matthew Weiland, Alexandra Vander Ark, Lukai Zhai, Kin Lau, Mario Corrado, Paula Davidson, Ebenezer Asiedu, Batsirai Mabvakure, Shelby Compton, Lisa DeCamp, Catherine A. Scullion, Russell G. Jones, Sara M. Nowinski, Connie M. Krawczyk
Publikováno v:
Cell Reports, Vol 43, Iss 8, Pp 114506- (2024)
Summary: Functional and phenotypic heterogeneity of dendritic cells (DCs) play crucial roles in facilitating the development of diverse immune responses essential for host protection. Here, we report that KDM5C, a histone lysine demethylase, regulate
Externí odkaz:
https://doaj.org/article/7912e7450a604454a8a5bc93c75f0f1a
Autor:
Hannah Guak, Ryan D. Sheldon, Ian Beddows, Alexandra Vander Ark, Matthew J. Weiland, Hui Shen, Russell G. Jones, Julie St-Pierre, Eric H. Ma, Connie M. Krawczyk
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-14 (2022)
Abstract Metabolic programming of the innate immune cells known as dendritic cells (DCs) changes in response to different stimuli, influencing their function. While the mechanisms behind increased glycolytic metabolism in response to inflammatory sti
Externí odkaz:
https://doaj.org/article/6f4583858e0a41b89b2cf4aaa9094f6e
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
The CD8 T cell response to Zika virus is known to be a critical component of the host immune response to infection. Here the authors show a Zika virus isolate specific disruption of antigen processing that impacts the host response and impairs viral
Externí odkaz:
https://doaj.org/article/9ad3084949b04a9a9eb30dc2b3b1576b
Autor:
Brendan Cordeiro, Peter Jeon, Giselle M. Boukhaled, Mario Corrado, Orsolya Lapohos, Dominic G. Roy, Kelsey Williams, Russell G. Jones, Samantha Gruenheid, Selena M. Sagan, Connie M. Krawczyk
Publikováno v:
Cell Reports, Vol 31, Iss 5, Pp - (2020)
Summary: Dendritic cells, cells of the innate immune system, are found in a steady state poised to respond to activating stimuli. Once stimulated, they rapidly undergo dynamic changes in gene expression to adopt an activated phenotype capable of stim
Externí odkaz:
https://doaj.org/article/bdfb2ccc8fcf48c08209ddf4aa111659
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Epigenetics has widespread implications in a variety of cellular processes ranging from cell identity and specification, to cellular adaptation to environmental stimuli. While typically associated with heritable changes in gene expression, epigenetic
Externí odkaz:
https://doaj.org/article/831565f5182e4e93b425890159b30eba
Autor:
Giselle M. Boukhaled, Brendan Cordeiro, Genevieve Deblois, Vassil Dimitrov, Swneke D. Bailey, Thomas Holowka, Anisa Domi, Hannah Guak, Huai-Hsuan Clare Chiu, Bart Everts, Edward J. Pearce, Mathieu Lupien, John H. White, Connie M. Krawczyk
Publikováno v:
Cell Reports, Vol 16, Iss 7, Pp 1829-1837 (2016)
Pro-inflammatory signals provided by the microenvironment are critical to activate dendritic cells (DCs), components of the innate immune system that shape both innate and adaptive immunity. However, to prevent inappropriate immune activation, mechan
Externí odkaz:
https://doaj.org/article/8c33a8fcc6be440dae00c85bc3811e39
Autor:
Hannah Guak, Matthew J Weiland, Alexandra R VanderArk, Lukai Zhai, Kin Lau, Batsi Mabvakure, Mario Corrado, Paula Davidson, Shelby Compton, Lisa DeCamp, Russell M Jones, Sara Nowinski, Connie M Krawczyk
The functional and phenotypic heterogeneity of dendritic cells (DCs) plays a crucial role in facilitating the development of diverse immune responses that are essential for providing host protection. We found that KDM5C, a histone lysine demethylase
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::19735fb6d1ff75d17a5457ce0b14ac09
https://doi.org/10.1101/2023.05.28.542441
https://doi.org/10.1101/2023.05.28.542441
Autor:
Shelby E. Compton, Susan M. Kitchen-Goosen, Lisa M. DeCamp, Kin H. Lau, Batsirai Mabvakure, Matthew Vos, Kelsey S. Williams, Kwok-Kin Wong, Xiaobing Shi, Scott B. Rothbart, Connie M. Krawczyk, Russell G. Jones
Publikováno v:
Molecular Cell.
Autor:
Bibo Zhu, Xiaoqin Wei, Harish Narasimhan, Wei Qian, Ruixuan Zhang, In Su Cheon, Yue Wu, Chaofan Li, Russell G. Jones, Mark H. Kaplan, Robert A. Vassallo, Thomas J. Braciale, Lindsay Somerville, Jerry R. Colca, Akhilesh Pandey, Patrick E. H. Jackson, Barbara J. Mann, Connie M. Krawczyk, Jeffrey M. Sturek, Jie Sun
Publikováno v:
Science Immunology. 8
The relationship between diabetes and coronavirus disease 2019 (COVID-19) is bidirectional: Although individuals with diabetes and high blood glucose (hyperglycemia) are predisposed to severe COVID-19, severe acute respiratory syndrome coronavirus 2
Publikováno v:
bioRxiv
Women experience osteoporosis at higher rates than men. Aside from hormones, the mechanisms driving sex-dependent bone mass regulation are not well-understood. Here, we demonstrate that the X-linked H3K4me2/3 demethylase KDM5C regulates sex-specific
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f059eb7daebae9452c7bc3e55b2a44b0
https://doi.org/10.1101/2023.02.23.529728
https://doi.org/10.1101/2023.02.23.529728