Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Connie M Gryniewicz-Ruzicka"'
Publikováno v:
Analytical Chemistry. 92:7547-7555
A recently developed synchronous precursor selection (SPS) mass spectrometry to the third (MS3) protocol enables more accurate multiplexed quantification of proteins/peptides using tandem mass tags (TMT) through comparison of reporter ion intensities
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97f6084175ed00873c9f5fe85803a0ca
https://doi.org/10.1021/acs.analchem.0c00014
https://doi.org/10.1021/acs.analchem.0c00014
Screening of Polysorbate-80 Composition by High Resolution Mass Spectrometry with Rapid H/D Exchange
Autor:
Asha Hewarathna, Ilan Geerlof-Vidavsky, Kui Yang, V. Ashutosh Rao, Connie M Gryniewicz-Ruzicka, David A. Keire
Publikováno v:
Analytical Chemistry. 91:14649-14656
Polysorbate (PS) is a widely used polymeric excipient in biotherapeutic formulations to stabilize and protect protein drugs. Commercial PS is a highly heterogeneous mixture of structurally related components. PS composition can impact the stabilizer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b52f951515e589c66020d6cd82ad33ff
https://doi.org/10.1021/acs.analchem.9b03809
https://doi.org/10.1021/acs.analchem.9b03809
Publikováno v:
Journal of Pharmaceutical and Biomedical Analysis. 134:282-286
An ion mobility spectrometry (IMS) method was developed for the rapid detection of mitragynine, the most abundant alkaloid in Mitragyna speciosa also known as kratom. The peak corresponding to the mitragynine protonated ion exhibited a reduced ion mo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2869560d0a151e5d47a202edd1529fd3
https://doi.org/10.1016/j.jpba.2016.11.055
https://doi.org/10.1016/j.jpba.2016.11.055
Publikováno v:
Applied spectroscopy. 71(8)
Exposure to unknown, mislabeled, and counterfeit pharmaceutical products is a worldwide problem that presents a serious risk to public health. Near-infrared (NIR) spectroscopy can serve as a useful tool for screening pharmaceuticals in a rapid and co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95abb3f9af5a513a589ba70ab7b40482
https://pubmed.ncbi.nlm.nih.gov/28393531
https://pubmed.ncbi.nlm.nih.gov/28393531
Autor:
Lucinda F. Buhse, Sergey Arzhantsev, Connie M. Gryniewicz-Ruzicka, Jason D. Rodriguez, John F. Kauffman
Publikováno v:
Journal of Pharmaceutical and Biomedical Analysis. 61:191-198
In this study, pharmaceutical grade sorbitol was used as a model system for comparison of Raman based library spectral correlation methods with more sophisticated methods of chemometric data analysis. Both crystallizing sorbitol (CS) and non-crystall
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79b12f2d3a2d1331fc817ef216f31285
https://doi.org/10.1016/j.jpba.2011.12.002
https://doi.org/10.1016/j.jpba.2011.12.002
Autor:
Judith N. Currano, William G. Town, William Town, Kenneth R. Foster, Frederick W. Stoss, Francois Busquet, Michele Palopoli, Thomas Hartung, George Lunn, Christopher Proctor, Derek Mariner, Kevin McAdam, Helena Hogberg, Rodger D. Curren, David P. Richardson, István Pelczer, Cristine Ha, Joseph G. Lelinho, Jason D. Rodriguez, Connie M. Gryniewicz-Ruzicka, Sergey Arzhantsev, John F. Kauffman, Lucinda F. Buhse
Autor:
Laura C. Mecker-Pogue, Jamie D. Dunn, Xia Ge, Daniel J. Mans, Ashley C. Gucinski, Jeff L.-F. Kao, Connie M. Gryniewicz-Ruzicka
Publikováno v:
Journal of pharmaceutical and biomedical analysis. 83
A novel analogue of sibutramine, 11-desisobutyl-11-benzylsibutramine, has been discovered. During routine ion mobility spectrometry (IMS) screening of a weight loss supplement collected at an US FDA import operation facility an unknown peak was obser
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59455f9ff8efb98eb102108f4df9b4dc
https://pubmed.ncbi.nlm.nih.gov/23739298
https://pubmed.ncbi.nlm.nih.gov/23739298
Publikováno v:
Journal of pharmaceutical and biomedical analysis. 75
Ion mobility spectrometry was used as a rapid screening tool for the detection of acetildenafils, sildenafils and avanafil within adulterated herbal supplement matrices. Acetildenafils show a tendency for partial fragmentation during the desorption/i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c4d60800a9b7adcf04324dae745c56f
https://pubmed.ncbi.nlm.nih.gov/23262416
https://pubmed.ncbi.nlm.nih.gov/23262416
Autor:
Jamie D. Dunn, Daniel J. Mans, Lucinda F. Buhse, Laura C. Mecker-Pogue, Benjamin J. Westenberger, Connie M. Gryniewicz-Ruzicka, John F. Kauffman
Publikováno v:
Journal of pharmaceutical and biomedical analysis. 71
Ion mobility spectrometry (IMS) served as a rapid, qualitative screening tool for the analysis of adulterated weight-loss products. We have previously shown that sibutramine extracted into methanol from dietary supplements can be detected at low leve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a315ed87150003e7e2970ca97407023d
https://pubmed.ncbi.nlm.nih.gov/22902504
https://pubmed.ncbi.nlm.nih.gov/22902504
Autor:
Connie M. Gryniewicz-Ruzicka, Katherine M. Tyner, John F. Kauffman, Daniel J. Mans, Laura C. Mecker, Sergey Arzhantsev
Publikováno v:
Analytica chimica acta. 733
Melamine adulteration of food and pharmaceutical products is a major concern and there is a growing need to protect the public from exposure to contaminated or adulterated products. One approach to reduce this threat is to develop a portable method f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de1dc504bf1637672f9551a2ed667de1
https://pubmed.ncbi.nlm.nih.gov/22704375
https://pubmed.ncbi.nlm.nih.gov/22704375