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Oxidation of Raloxifene to Quinoids: Potential Toxic Pathways via a Diquinone Methide and o-Quinones
Autor:
Wenkui Li, Fagen Zhang, Gregory R. J. Thatcher, Judy L. Bolton, Linning Yu, Hong Liu, Connie Luckie, Richard B. van Breemen
Publikováno v:
Chemical Research in Toxicology. 17:879-888
Raloxifene was approved in 1997 by the FDA for the treatment of osteoporosis in postmenopausal women, and it is currently in clinical trials for the chemoprevention of breast cancer. Before widespread use as a chemopreventive agent in healthy women,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f65eeb3685ba04b6c0db9c6d7c6e9f31
https://doi.org/10.1021/tx0342722
https://doi.org/10.1021/tx0342722
