Zobrazeno 1 - 10
of 54
pro vyhledávání: '"Connie L Sommers"'
Autor:
Nirali Shah, Lili Yang, Anju Singh, Kasia Bourcier, Antoni Ribas, Pawel Kalinski, Ke Liu, Phil Greenberg, Carl June, Marcela Maus, Steven Rosenberg, Madhav Dhodapkar, Irina Tiper, Chantale Bernatchez, Michael Hudecek, Stanley Riddell, Stephen Gottschalk, Crystal Mackall, Lisa Butterfield, Greg Delgoffe, Michael Nishimura, Terry Fry, Marc S. Ernstoff, Christopher Klebanoff, Elad Sharon, Malcolm Brenner, Cliona Rooney, Christine Brown, Marc S Ernstoff, Tonya Webb, Magdalena Thurin, Wendell Lim, David Stroncek, Catherine Bollard, Helen Chen, Cameron Turtle, Christian Hinrichs, Laura K Fogli, Rosemarie Aurigemma, Connie L Sommers, Steven Albelda, Renier Brentjens, Yvonne Chen, Laronna Colbert, Kenneth Cornetta, Jason Cristofaro, Thomas Finn, Laura K Fogli Hunter, Alyssa Galaro, Ananda Goldrath, Ray Harris, Lori Henderson, Yuxia Jia, Dan Kaufman, Bruce Levine, Lawrence Lum, Samantha Maragh, Alex Marson, Raj Puri, Jake Reder, Kole Roybal, Rachelle Salomon, Tal Salz, Barbra Sasu, Andrea Schietinger, Connie L. Sommers, Minkyung Song, Fyodor Urnov, Anthony Welch, Travis Young, Jason Yovandich
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 9, Iss 7 (2021)
Cell-based immunotherapies have had remarkable success in the clinic, specifically in the treatment of hematologic malignancies. However, these strategies have had limited efficacy in patients with solid tumors. To better understand the challenges in
Externí odkaz:
https://doaj.org/article/f4500c9773db47d7abfb74eccac2d857
Autor:
Alexandre K Rouquette-Jazdanian, Robert L Kortum, Wenmei Li, Robert K Merrill, Phan H Nguyen, Lawrence E Samelson, Connie L Sommers
Publikováno v:
PLoS ONE, Vol 10, Iss 6, p e0131823 (2015)
Linker for Activation of T cells (LAT) is an adapter protein that is essential for T cell function. Knock-in mice with a LAT mutation impairing calcium flux develop a fatal CD4+ lymphoproliferative disease. miR-155 is a microRNA that is correlated wi
Externí odkaz:
https://doaj.org/article/03cf505e37834812bd4cc6d93e2df137
Autor:
Connie L Sommers, Alexandre K Rouquette-Jazdanian, Ana I Robles, Robert L Kortum, Robert K Merrill, Wenmei Li, Nandan Nath, Elizabeth Wohlfert, Katherine M Sixt, Yasmine Belkaid, Lawrence E Samelson
Publikováno v:
PLoS ONE, Vol 8, Iss 6, p e66709 (2013)
Helper T cells from a mutant mouse model, LAT Y136F, hyper-proliferate and cause a severe lymphoproliferative disease that kills the mice by six months of age. LAT Y136F mice carry a tyrosine to phenylalanine mutation in the Linker for Activation of
Externí odkaz:
https://doaj.org/article/b7f3e2322d024f03b46f3a24eadde5b5
Autor:
Lawrence E. Samelson, Grace Bugos, Lijin Dong, Sunmee Huh, Connie L. Sommers, Xing Li, Chuan-Jin Wu, Wenmei Li, Kiyoto Kurima, Andrew J. Griffith
Publikováno v:
J Biol Chem
The TMC genes encode a set of homologous transmembrane proteins whose functions are not well understood. Biallelic mutations in either TMC6 or TMC8 are detected in more than half of cases of the pre-malignant skin disease epidermodysplasia verrucifor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::225db6a6ff3c37fd722103681a3887d3
https://doi.org/10.1074/jbc.ra120.013045
https://doi.org/10.1074/jbc.ra120.013045
Autor:
Connie L. Sommers, Katarzyna Bourcier, Colleen S Curran, Marie Mancini, Elad Sharon, Howard A. Young
Publikováno v:
J Immunol
With the increased use of cancer immunotherapy, a number of immune-related adverse events (irAEs) are being identified. These irAEs can be compared with known autoimmune disorders in similar tissues, with important similarities and differences. Under
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c980c6a0eb631641a187e26c34a97c0
https://europepmc.org/articles/PMC7365167/
https://europepmc.org/articles/PMC7365167/
Autor:
Lakshmi Balagopalan, Geoffrey Guittard, Connie L. Sommers, Nicolas Çuburu, Robert L. Kortum, Lawrence E. Samelson, Phan H. Nguyen
Publikováno v:
European Journal of Immunology. 45:2389-2395
Sos-1 and Sos-2 are ubiquitously expressed Ras-guanine exchange factors involved in Erk-MAP kinase pathway activation. Using mice lacking genes encoding Sos-1 and Sos-2, we evaluated the role of these proteins in peripheral T-cell signaling and funct
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c16469cc2c06d2965f85bd9200cf11d1
https://doi.org/10.1002/eji.201445226
https://doi.org/10.1002/eji.201445226
Autor:
Jeffrey Baron, Connie L. Sommers, Wenmei Li, Roberto Weigert, Julian C. Lui, Devorah L. Gallardo, Sunmee Huh, Geoffrey Guittard, Nicolas Melis, Robert L. Kortum, Lawrence E. Samelson, Nicholas G. Shakarishvili, Joshua A. Kramer
Publikováno v:
Frontiers in Immunology
RAS signaling is central to many cellular processes and SOS proteins promote RAS activation. To investigate the role of SOS proteins in T cell biology, we crossed Sos1f/f Sos2−/− mice to CD4-Cre transgenic mice. We previously reported an effect o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ddecf3013ef096ddcb454e73797485e
Autor:
Michihiko Miyaji, Alexandre K. Rouquette-Jazdanian, Evan Markegard, John M. Pinski, Connie L. Sommers, Amelia K. Wesselink, Lawrence E. Samelson, Clayton P. Alexander, Jeroen P. Roose, Nandan N. Nath, Wenmei Li, Peter M. Blumberg, Robert L. Kortum, Robert K. Merrill, Noemi Kedei
Publikováno v:
The Journal of Immunology. 190:147-158
Mice expressing a germline mutation in the phospholipase C-γ1–binding site of linker for activation of T cells (LAT) show progressive lymphoproliferation and ultimately die at 4–6 mo age. The hyperactivated T cells in these mice show defective T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a3235114a40d040b26ce738e722887fa
https://doi.org/10.4049/jimmunol.1201458
https://doi.org/10.4049/jimmunol.1201458
Autor:
Lawrence E. Samelson, Eilon Sherman, Carole K. Regan, Connie L. Sommers, Robert K. Merrill, Valarie A. Barr
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
Nature Communications
Nature Communications
Signalling complexes are dynamic, multimolecular structures and sites for intracellular signal transduction. Although they play a crucial role in cellular activation, current research techniques fail to resolve their structure in intact cells. Here w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17ce800c1b4d7096cfabc49fa42b50a2
https://doi.org/10.1038/ncomms12161
https://doi.org/10.1038/ncomms12161
Autor:
Robert L. Kortum, Lawrence E. Samelson, Deborah K. Morrison, Connie L. Sommers, Alexandre K. Rouquette-Jazdanian
Publikováno v:
Molecular Cell. 48:298-312
In T cells the adapter Bam32 is coupled to Erk activation downstream of the TCR by an unknown mechanism. We characterized in Jurkat cells and primary T lymphocytes, a pathway dependent on Bam32-PLC-γ1-Pak1 complexes, in which Pak1 kinase activates R
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a1bd257fc1d0e80e115aac960e0544e
https://doi.org/10.1016/j.molcel.2012.08.011
https://doi.org/10.1016/j.molcel.2012.08.011