Zobrazeno 1 - 10
of 535
pro vyhledávání: '"Connie J Eaves"'
Autor:
Haixia Zhou, Yue Ge, Lili Sun, Wenjuan Ma, Jie Wu, Xiuyan Zhang, Xiaohui Hu, Connie J Eaves, Depei Wu, Yun Zhao
Publikováno v:
PLoS ONE, Vol 9, Iss 1, p e86195 (2014)
Although the generation of BCR-ABL is the molecular hallmark of chronic myeloid leukemia (CML), the comprehensive molecular mechanisms of the disease remain unclear yet. Growth arrest specific 2 (GAS2) regulates multiple cellular functions including
Externí odkaz:
https://doaj.org/article/d3d0dc832efa4e8c8663d2abe7c5da2b
Autor:
Courteney K Lai, Yeonsook Moon, Florian Kuchenbauer, Daniel T Starzcynowski, Bob Argiropoulos, Eric Yung, Philip Beer, Adrian Schwarzer, Amit Sharma, Gyeongsin Park, Malina Leung, Grace Lin, Sarah Vollett, Stephen Fung, Connie J Eaves, Aly Karsan, Andrew P Weng, R Keith Humphries, Michael Heuser
Publikováno v:
PLoS ONE, Vol 9, Iss 11, p e112671 (2014)
Extensive molecular profiling of leukemias and preleukemic diseases has revealed that distinct clinical entities, like acute myeloid (AML) and T-lymphoblastic leukemia (T-ALL), share similar pathogenetic mutations. It is not well understood how the c
Externí odkaz:
https://doaj.org/article/ef4a04d6af37476aa1377dc32893568c
Autor:
Ebrahim Eskandari, Gian Luca Negri, Susanna Tan, Margarita E. MacAldaz, Shengsen Ding, Justin Long, Karina Nielsen, Sandra E. Spencer, Gregg B. Morin, Connie J. Eaves
Publikováno v:
Cell Death Discovery, Vol 10, Iss 1, Pp 1-9 (2024)
Abstract Mechanisms that regulate cell survival and proliferation are important for both the development and homeostasis of normal tissue, and as well as for the emergence and expansion of malignant cell populations. Caspase-3 (CASP3) has long been r
Externí odkaz:
https://doaj.org/article/32b80a46192c4ea28535552dcc26b8da
Autor:
Maisam Makarem, Nagarajan Kannan, Long V Nguyen, David J H F Knapp, Sneha Balani, Michael D Prater, John Stingl, Afshin Raouf, Oksana Nemirovsky, Peter Eirew, Connie J Eaves
Publikováno v:
PLoS Biology, Vol 11, Iss 8, p e1001630 (2013)
Many normal adult tissues contain rare stem cells with extensive self-maintaining regenerative potential. During development, the stem cells of the hematopoietic and neural systems undergo intrinsically specified changes in their self-renewal potenti
Externí odkaz:
https://doaj.org/article/f5e5ef86b0bd4ec39f0359d8283539c8
Autor:
Daniel W Serber, Allison Rogala, Maisam Makarem, Gary B Rosson, Karl Simin, Virginia Godfrey, Terry Van Dyke, Connie J Eaves, Scott J Bultman
Publikováno v:
PLoS ONE, Vol 7, Iss 2, p e31346 (2012)
The BRG1 catalytic subunit of SWI/SNF-related complexes is required for mammalian development as exemplified by the early embryonic lethality of Brg1 null homozygous mice. BRG1 is also a tumor suppressor and, in mice, 10% of heterozygous (Brg1(null/+
Externí odkaz:
https://doaj.org/article/489315340d2f4253a20c5efede80de1c
Autor:
Jennifer H Law, Yvonne Li, Karen To, Michelle Wang, Arezoo Astanehe, Karen Lambie, Jaspreet Dhillon, Steven J M Jones, Martin E Gleave, Connie J Eaves, Sandra E Dunn
Publikováno v:
PLoS ONE, Vol 5, Iss 9, p e12661 (2010)
The Y-box binding protein-1 (YB-1) is an oncogenic transcription/translation factor that is activated by phosphorylation at S102 whereby it induces the expression of growth promoting genes such as EGFR and HER-2. We recently illustrated by an in vitr
Externí odkaz:
https://doaj.org/article/3147afe5871e4fafa2b7c7e078bf833e
Publikováno v:
PLoS ONE, Vol 5, Iss 10, p e13372 (2010)
BACKGROUND: In the bovine species milk production is well known to correlate with mammary tissue mass. However, most advances in optimizing milk production relied on improvements of breeding and husbandry practices. A better understanding of the cell
Externí odkaz:
https://doaj.org/article/fdbe8fd011174f52856dd06e2dd5e273
Publikováno v:
Canadian Journal of Infectious Diseases, Vol 3, Iss Suppl B, Pp 123-127 (1992)
Despite the use of high dose chemoradiotherapy for the treatment of acute leukemia. relapse continues to be a major cause of death in patients given an autologous bone marrow transplant. Further augmentation of pretransplant chemotherapy causes life
Externí odkaz:
https://doaj.org/article/8923e433cd774d05aaff836d899d3ff3
Autor:
Clive H Glover, Michael Marin, Connie J Eaves, Cheryl D Helgason, James M Piret, Jennifer Bryan
Publikováno v:
PLoS Computational Biology, Vol 2, Iss 11, p e158 (2006)
Stem cell differentiation involves critical changes in gene expression. Identification of these should provide endpoints useful for optimizing stem cell propagation as well as potential clues about mechanisms governing stem cell maintenance. Here we
Externí odkaz:
https://doaj.org/article/245addf23271452a8c2d7e293a777a5f
Autor:
Francesca Mateo, Zhengcheng He, Lin Mei, Gorka Ruiz de Garibay, Carmen Herranz, Nadia García, Amanda Lorentzian, Alexandra Baiges, Eline Blommaert, Antonio Gómez, Oriol Mirallas, Anna Garrido-Utrilla, Luis Palomero, Roderic Espín, Ana I. Extremera, M. Teresa Soler-Monsó, Anna Petit, Rong Li, Joan Brunet, Ke Chen, Susanna Tan, Connie J. Eaves, Curtis McCloskey, Razq Hakem, Rama Khokha, Philipp F. Lange, Conxi Lázaro, Christopher A. Maxwell, Miquel Angel Pujana
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
The effect of hyaluronan-mediated motility receptor (HMMR) expression in BRCA1-associated breast cancer risk remains unknown. Here, HMMR overexpression induces the activation of cGAS-STING and non-canonical NF-κB signalling, instigating an immune pe
Externí odkaz:
https://doaj.org/article/63fe713cc69c441fb5f6ed1eab75272b