Zobrazeno 1 - 10
of 774
pro vyhledávání: '"Connie J Eaves"'
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.
K zobrazení výsledku je třeba se přihlásit.
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.
K zobrazení výsledku je třeba se přihlásit.
Autor:
Ebrahim Eskandari, Gian Luca Negri, Susanna Tan, Margarita E. MacAldaz, Shengsen Ding, Justin Long, Karina Nielsen, Sandra E. Spencer, Gregg B. Morin, Connie J. Eaves
Publikováno v:
Cell Death Discovery, Vol 10, Iss 1, Pp 1-9 (2024)
Abstract Mechanisms that regulate cell survival and proliferation are important for both the development and homeostasis of normal tissue, and as well as for the emergence and expansion of malignant cell populations. Caspase-3 (CASP3) has long been r
Externí odkaz:
https://doaj.org/article/32b80a46192c4ea28535552dcc26b8da
Autor:
Zhengcheng He, Ryan Ghorayeb, Susanna Tan, Ke Chen, Amanda C. Lorentzian, Jack Bottyan, Syed Mohammed Musheer Aalam, Miguel Angel Pujana, Philipp F. Lange, Nagarajan Kannan, Connie J. Eaves, Christopher A. Maxwell
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
Female carriers of BRCA1 mutations possess high breast cancer risk, which may reflect deficient growth control of mammary progenitor cells. Here, the authors study progenitor-enriched fractions from these carriers and describe a loss of PLK1-mediated
Externí odkaz:
https://doaj.org/article/dc008dd191494a1c87bda1b62ace4d8c
Autor:
Francesca Mateo, Zhengcheng He, Lin Mei, Gorka Ruiz de Garibay, Carmen Herranz, Nadia García, Amanda Lorentzian, Alexandra Baiges, Eline Blommaert, Antonio Gómez, Oriol Mirallas, Anna Garrido-Utrilla, Luis Palomero, Roderic Espín, Ana I. Extremera, M. Teresa Soler-Monsó, Anna Petit, Rong Li, Joan Brunet, Ke Chen, Susanna Tan, Connie J. Eaves, Curtis McCloskey, Razq Hakem, Rama Khokha, Philipp F. Lange, Conxi Lázaro, Christopher A. Maxwell, Miquel Angel Pujana
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
The effect of hyaluronan-mediated motility receptor (HMMR) expression in BRCA1-associated breast cancer risk remains unknown. Here, HMMR overexpression induces the activation of cGAS-STING and non-canonical NF-κB signalling, instigating an immune pe
Externí odkaz:
https://doaj.org/article/63fe713cc69c441fb5f6ed1eab75272b
Autor:
Juan Carlos Rivera-Mulia, Takayo Sasaki, Claudia Trevilla-Garcia, Naoto Nakamichi, David J. H.F. Knapp, Colin A. Hammond, Bill H. Chang, Jeffrey W. Tyner, Meenakshi Devidas, Jared Zimmerman, Kyle N. Klein, Vivek Somasundaram, Brian J. Druker, Tanja A. Gruber, Amnon Koren, Connie J. Eaves, David M. Gilbert
Publikováno v:
Blood Advances, Vol 3, Iss 21, Pp 3201-3213 (2019)
Abstract: Human B-cell precursor acute lymphoid leukemias (BCP-ALLs) comprise a group of genetically and clinically distinct disease entities with features of differentiation arrest at known stages of normal B-lineage differentiation. We previously s
Externí odkaz:
https://doaj.org/article/813e5445336443a09e50cbf90d7c35a2
Autor:
Manabu Kusakabe, Ann Chong Sun, Kateryna Tyshchenko, Rachel Wong, Aastha Nanda, Claire Shanna, Samuel Gusscott, Elizabeth A. Chavez, Alireza Lorzadeh, Alice Zhu, Ainsleigh Hill, Stacy Hung, Scott Brown, Artem Babaian, Xuehai Wang, Robert A. Holt, Christian Steidl, Aly Karsan, R. Keith Humphries, Connie J. Eaves, Martin Hirst, Andrew P. Weng
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
Studies with patient derived xenografts are hampered by factors such as genetic variability and sample availability. Here, the authors generate a leukemia mouse model by lentiviral transduction of normal human cord blood and show an oncogenic role of
Externí odkaz:
https://doaj.org/article/0dc063f01a744a6691471a7f27cd84dc
Autor:
Sofia von Palffy, Niklas Landberg, Carl Sandén, Dimitra Zacharaki, Mansi Shah, Naoto Nakamichi, Nils Hansen, Maria Askmyr, Henrik Lilljebjörn, Marianne Rissler, Christine Karlsson, Stefan Scheding, Johan Richter, Connie J. Eaves, Ravi Bhatia, Marcus Järås, Thoas Fioretos
Publikováno v:
Haematologica, Vol 105, Iss 8 (2020)
Aberrantly expressed cytokines in the bone marrow (BM) niche are increasingly recognized as critical mediators of survival and expansion of leukemic stem cells. To identify regulators of primitive chronic myeloid leukemia (CML) cells, we performed a
Externí odkaz:
https://doaj.org/article/c454c8a9cb454ff1b71b59ec50cae9ec
Autor:
Ivan Sloma, Philip Beer, Christophe Desterke, Elizabeth Bulaeva, Misha Bilenky, Annaïck Carles, Michelle Moksa, Kamini Raghuram, Cedric Brimacombe, Karen Lambie, Ali G. Turhan, Orianne Wagner-Ballon, Philippe Gaulard, Keith Humphries, Martin Hirst, Connie J. Eaves
Publikováno v:
Haematologica, Vol 106, Iss 3 (2020)
Externí odkaz:
https://doaj.org/article/e3289cdd224d4b4dbd0c6f7ca627e4bb
Autor:
Connie J. Eaves
Publikováno v:
Stem Cell Reports, Vol 11, Iss 5, Pp 1034-1039 (2018)
Decades of lack of progress in treating many fatal malignancies of the blood-forming system is commanding interest in new approaches. Targeting early events in the leukemogenic process has long been recognized as likely to offer the information requi
Externí odkaz:
https://doaj.org/article/f5efddaab7194b6c84e48540669b6dac