Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Connie I. Lord"'
Publikováno v:
PLoS ONE, Vol 13, Iss 7, p e0200444 (2018)
Neutrophils are the most abundant white blood cells, with a vital role in innate immune defense against bacterial and fungal pathogens. Although mostly associated with pathological processes directly related to immune defense, they can also play a de
Externí odkaz:
https://doaj.org/article/6d72db8bbf3f47d2b6ab1b9980a01904
Autor:
Marcia H. Riesselman, James B. Burritt, Jeannie M. Gripentrog, Algirdas J. Jesaitis, Connie I. Lord, Ross M. Taylor
Publikováno v:
Journal of Immunological Methods. 329:201-207
Human neutrophil flavocytochrome b (Cyt b) is a heterodimeric, integral membrane protein that generates high levels of superoxide in the multisubunit NADPH oxidase complex. Since Cyt b is currently isolated in limited quantities, improved methods for
Autor:
Edgar Pick, Algirdas J. Jesaitis, Thomas L. Leto, Marcia H. Riesselman, Linda C. McPhail, Jeannie M. Gripentrog, Yevgeny Berdichevsky, Connie I. Lord, Ross M. Taylor
Publikováno v:
Biochemistry. 46:14291-14304
The heterodimeric, integral membrane protein flavocytochrome b (Cyt b) is the catalytic core of the phagocyte NADPH oxidase and generates superoxide which plays a critical role in host defense. To better define the activation of superoxide production
Autor:
Jamal Stie, Connie I. Lord, Ross M. Taylor, Algirdas J. Jesaitis, Jeannie M. Gripentrog, James B. Burritt, Andrew V. Jesaitis
Publikováno v:
Journal of Leukocyte Biology. 82:161-172
The well-described antimicrobial and immunoregulatory properties of human cathelicidin antimicrobial protein 18 (hCAP-18) derive in part from the ability of its proteolytic fragment, LL-37 (a.k.a. CAP-37), to associate with activated immune and epith
Autor:
James B. Burritt, Charles A. Parkos, Travis D. Baughan, Danas Baniulis, John S. Mills, Algirdas J. Jesaitis, Dirk Roos, Thomas R. Foubert, Connie I. Lord, Ross M. Taylor
Publikováno v:
Journal of immunology (Baltimore, Md., 170(12), 6082-6089. American Association of Immunologists
mAb NL7 was raised against purified flavocytochrome b558, important in host defense and inflammation. NL7 recognized the gp91phox flavocytochrome b558 subunit by immunoblot and bound to permeabilized neutrophils and neutrophil membranes. Epitope mapp
Autor:
Brian Bothner, Ting Liu, Edward A. Dratz, Algirdas J. Jesaitis, Connie I. Lord, Gal Keren-Aviram, Walid S. Maaty, Jeannie M. Gripentrog, Marcia H. Riesselman
Publikováno v:
The Journal of biological chemistry. 288(38)
Accumulation, activation, and control of neutrophils at inflammation sites is partly driven by N-formyl peptide chemoattractant receptors (FPRs). Occupancy of these G-protein-coupled receptors by formyl peptides has been shown to induce regulatory ph
Autor:
Jamal Stie, Jeannie M. Gripentrog, Heini M. Miettinen, Algirdas J. Jesaitis, Marcia H. Riesselman, Edward A. Dratz, Connie I. Lord, Ross M. Taylor, Brendan Mumey
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 179(4)
The N-formyl peptide receptor (FPR), a G protein-coupled receptor that binds proinflammatory chemoattractant peptides, serves as a model receptor for leukocyte chemotaxis. Recombinant histidine-tagged FPR (rHis-FPR) was purified in lysophosphatidyl g
Autor:
James B. Burritt, Connie I. Lord, Marcia H. Riesselman, Edward A. Dratz, Brian Bothner, Gilda F. Linton, Thomas E. Angel, Algirdas J. Jesaitis, Jeannie M. Gripentrog, Harry L. Malech, Danas Baniulis, Ross M. Taylor, Walid S. Maaty
Publikováno v:
The Journal of biological chemistry. 281(48)
The catalytic core of the phagocyte NADPH oxidase is a heterodimeric integral membrane protein (flavocytochrome b (Cyt b)) that generates superoxide and initiates a cascade of reactive oxygen species critical for the host inflammatory response. In or
Autor:
Trinity L. Hamilton, Walid S. Maaty, James B. Burritt, Algirdas J. Jesaitis, Ross M. Taylor, Connie I. Lord, Brian Bothner
Publikováno v:
Molecular immunology. 44(4)
The integral membrane protein flavocytochrome b (Cyt b) is the catalytic core of the NADPH oxidase complex, a multicomponent enzyme system that initiates a cascade of reactive oxygen species that play a critical role in innate immunity and vascular p
Autor:
Mary C. Dinauer, James B. Burritt, Ross M. Taylor, Danas Baniulis, Connie I. Lord, Charles A. Parkos, Thomas R. Foubert, Algirdas J. Jesaitis
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 173(12)
The integral membrane protein flavocytochrome b (Cyt b) is the catalytic core of the human phagocyte NADPH oxidase, an enzyme complex that initiates a cascade of reactive oxygen species important in the elimination of infectious agents. This study re