Zobrazeno 1 - 10
of 48
pro vyhledávání: '"Connie Ha"'
Autor:
Ernie Yulyaningsih, Jung H Suh, Melania Fanok, Roni Chau, Hilda Solanoy, Ryan Takahashi, Anna I Bakardjiev, Isabel Becerra, N Butch Benitez, Chi-Lu Chiu, Sonnet S Davis, William E Dowdle, Timothy Earr, Anthony A Estrada, Audrey Gill, Connie Ha, Patrick CG Haddick, Kirk R Henne, Martin Larhammar, Amy W-S Leung, Romeo Maciuca, Bahram Memarzadeh, Hoang N Nguyen, Alicia A Nugent, Maksim Osipov, Yingqing Ran, Kevin Rebadulla, Elysia Roche, Thomas Sandmann, Jing Wang, Joseph W Lewcock, Kimberly Scearce-Levie, Lesley A Kane, Pascal E Sanchez
Publikováno v:
eLife, Vol 12 (2024)
The integrated stress response (ISR) is a conserved pathway in eukaryotic cells that is activated in response to multiple sources of cellular stress. Although acute activation of this pathway restores cellular homeostasis, intense or prolonged ISR ac
Externí odkaz:
https://doaj.org/article/6521500dd1424027bebffc6920eba56b
Autor:
Dan Xia, Steve Lianoglou, Thomas Sandmann, Meredith Calvert, Jung H. Suh, Elliot Thomsen, Jason Dugas, Michelle E. Pizzo, Sarah L. DeVos, Timothy K. Earr, Chia-Ching Lin, Sonnet Davis, Connie Ha, Amy Wing-Sze Leung, Hoang Nguyen, Roni Chau, Ernie Yulyaningsih, Isabel Lopez, Hilda Solanoy, Shababa T. Masoud, Chun-chi Liang, Karin Lin, Giuseppe Astarita, Nathalie Khoury, Joy Yu Zuchero, Robert G. Thorne, Kevin Shen, Stephanie Miller, Jorge J. Palop, Dylan Garceau, Michael Sasner, Jennifer D. Whitesell, Julie A. Harris, Selina Hummel, Johannes Gnörich, Karin Wind, Lea Kunze, Artem Zatcepin, Matthias Brendel, Michael Willem, Christian Haass, Daniel Barnett, Till S. Zimmer, Anna G. Orr, Kimberly Scearce-Levie, Joseph W. Lewcock, Gilbert Di Paolo, Pascal E. Sanchez
Publikováno v:
Molecular Neurodegeneration, Vol 17, Iss 1, Pp 1-29 (2022)
Abstract Background Genetic mutations underlying familial Alzheimer’s disease (AD) were identified decades ago, but the field is still in search of transformative therapies for patients. While mouse models based on overexpression of mutated transge
Externí odkaz:
https://doaj.org/article/9eb417ef38964cb082e476c72c827f5f
Autor:
Stephanie E Hesselson, Pär Matsson, James E Shima, Hisayo Fukushima, Sook Wah Yee, Yuya Kobayashi, Jason M Gow, Connie Ha, Benjamin Ma, Annie Poon, Susan J Johns, Doug Stryke, Richard A Castro, Harunobu Tahara, Ji Ha Choi, Ligong Chen, Nicolas Picard, Elin Sjödin, Maarke J E Roelofs, Thomas E Ferrin, Richard Myers, Deanna L Kroetz, Pui-Yan Kwok, Kathleen M Giacomini
Publikováno v:
PLoS ONE, Vol 4, Iss 9, p e6942 (2009)
Membrane transporters play crucial roles in the cellular uptake and efflux of an array of small molecules including nutrients, environmental toxins, and many clinically used drugs. We hypothesized that common genetic variation in the proximal promote
Externí odkaz:
https://doaj.org/article/09fb7e921026438cb6a8f93630163930
Autor:
Scarlett J Barker, Mai B Thayer, Chaeyoung Kim, David Tatarakis, Matthew Simon, Rebekah L Dial, Lizanne Nilewski, Robert C Wells, Yinhan Zhou, Megan Afetian, Alfred Chappell, Kylie S Chew, Johann Chow, Allisa Clemens, Claire B Discenza, Jason Dugas, Chrissa Dwyer, Timothy Earr, Connie Ha, David Huynh, Srini Jayaraman, Wanda Kwan, Cathal Mahon, Michelle Pizzo, Elysia Roche, Laura Sanders, Alexander Stergioulis, Raymond Tong, Hai Tran, Joy Zuchero, Anthony A Estrada, Kapil Gadkar, Christopher MM Koth, Pascal E Sanchez, Robert G Thorne, Ryan J Watts, Thomas Sandmann, Lesley Kane, Frank Rigo, Mark S Dennis, Joseph W Lewcock, Sarah L DeVos
Antisense oligonucleotides (ASO) are promising therapies for neurological disorders, though they are unable to cross the blood-brain barrier (BBB) and must be delivered directly to the central nervous system (CNS). Here, we use a human transferrin re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::56046f97df89d6a2d15a721b2fca4f31
https://doi.org/10.1101/2023.04.25.538145
https://doi.org/10.1101/2023.04.25.538145
Autor:
Mark R. Lackner, Marcia Belvin, John Moffat, Garret M. Hampton, Lukas C. Amler, Lori S. Friedman, Kyung Song, Wei Zhou, Connie Ha, Karen Toy, Huifen Chen, Sherry Heldens, William F. Forrest, Robert Soriano, Peter M. Haverty, Klaus P. Hoeflich, Jill M. Spoerke, Carol O'Brien, Bonnie Liu, Georgia Hatzivassiliou
The RAS/RAF/MEK pathway is activated in more than 30% of human cancers, most commonly via mutation in the K-ras oncogene and also via mutations in BRAF. Several allosteric mitogen-activated protein/extracellular signal–regulated kinase (MEK) inhibi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07be02e8e9258d59fd0d5344faa763ab
https://doi.org/10.1158/1535-7163.c.6535320.v1
https://doi.org/10.1158/1535-7163.c.6535320.v1
Autor:
Mark R. Lackner, Marcia Belvin, John Moffat, Garret M. Hampton, Lukas C. Amler, Lori S. Friedman, Kyung Song, Wei Zhou, Connie Ha, Karen Toy, Huifen Chen, Sherry Heldens, William F. Forrest, Robert Soriano, Peter M. Haverty, Klaus P. Hoeflich, Jill M. Spoerke, Carol O'Brien, Bonnie Liu, Georgia Hatzivassiliou
PDF file - 451K
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3923262ef522e46408ad2b4fe9b478f6
https://doi.org/10.1158/1535-7163.22496553
https://doi.org/10.1158/1535-7163.22496553
Autor:
Bettina van Lengerich, Lihong Zhan, Dan Xia, Darren Chan, David Joy, Joshua I. Park, David Tatarakis, Meredith Calvert, Selina Hummel, Steve Lianoglou, Michelle E. Pizzo, Rachel Prorok, Elliot Thomsen, Laura M. Bartos, Philipp Beumers, Anja Capell, Sonnet S. Davis, Lis de Weerd, Jason C. Dugas, Joseph Duque, Timothy Earr, Kapil Gadkar, Tina Giese, Audrey Gill, Johannes Gnörich, Connie Ha, Malavika Kannuswamy, Do Jin Kim, Sebastian T. Kunte, Lea H. Kunze, Diana Lac, Kendra Lechtenberg, Amy Wing-Sze Leung, Chun-Chi Liang, Isabel Lopez, Paul McQuade, Anuja Modi, Vanessa O. Torres, Hoang N. Nguyen, Ida Pesämaa, Nicholas Propson, Marvin Reich, Yaneth Robles-Colmenares, Kai Schlepckow, Luna Slemann, Hilda Solanoy, Jung H. Suh, Robert G. Thorne, Chandler Vieira, Karin Wind-Mark, Ken Xiong, Y. Joy Yu Zuchero, Dolo Diaz, Mark S. Dennis, Fen Huang, Kimberly Scearce-Levie, Ryan J. Watts, Christian Haass, Joseph W. Lewcock, Gilbert Di Paolo, Matthias Brendel, Pascal E. Sanchez, Kathryn M. Monroe
Publikováno v:
Nature neuroscience 26, 416-429 (2023). doi:10.1038/s41593-022-01240-0
Loss-of-function variants of TREM2 are associated with increased risk of Alzheimer’s disease (AD), suggesting that activation of this innate immune receptor may be a useful therapeutic strategy. Here we describe a high-affinity human TREM2-activati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5a1a80e71ec71d0d797c20ae600bdaa
https://doi.org/10.1038/s41593-022-01240-0
https://doi.org/10.1038/s41593-022-01240-0
Autor:
Vaibhav Upadhyay, Rahul Suryawanshi, Preston Tasoff, Maria McCavitt-Malvido, G. Renuka Kumar, Victoria Wong Murray, Cecilia Noecker, Jordan E. Bisanz, Yulin Hswen, Connie Ha, Bharat Sreekumar, Irene P. Chen, Susan V Lynch, Melanie Ott, Sulggi Lee, Peter J. Turnbaugh
Publikováno v:
bioRxiv
Viruses targeting mammalian cells can indirectly alter the gut microbiota, potentially compounding their phenotypic effects. Multiple studies have observed a disrupted gut microbiota in severe cases of SARS-CoV-2 infection that require hospitalizatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::238c469306fed048d9dc89107c880a2e
https://doi.org/10.1101/2022.12.07.519508
https://doi.org/10.1101/2022.12.07.519508
Autor:
Assunta De Rienzo, Thong T. Nguyen, Raphael Bueno, Daniele Sciaranghella, Connie Ha, Lucian R. Chirieac, Na Zhang, Frederic J. de Sauvage, Karen Toy, Ying-Jiun Chen, Bijay S. Jaiswal, Subhra Chaudhuri, Florian Gnad, Somasekar Seshagiri, William G. Richards, Steffen Durinck, Zora Modrusan, Jason A. Hackney, Corinne E. Gustafson, Thomas D. Wu, Eric Stawiski, Nhien Dao, Joseph Guillory, Ravi Gupta, Kiara J. Munir, Jeremy Stinson, David J. Sugarbaker, Amitabha Chaudhuri, Leonard D. Goldstein
Publikováno v:
Nature Genetics. 48:407-416
We analyzed transcriptomes (n = 211), whole exomes (n = 99) and targeted exomes (n = 103) from 216 malignant pleural mesothelioma (MPM) tumors. Using RNA-seq data, we identified four distinct molecular subtypes: sarcomatoid, epithelioid, biphasic-epi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce5969015e07e8489010413b4c8d5077
https://doi.org/10.1038/ng.3520
https://doi.org/10.1038/ng.3520
Autor:
Connie Hassett-Walker
Publikováno v:
Substance Abuse: Research and Treatment, Vol 17 (2023)
Background: The current emphasis among addiction treatment providers is to use person-first language, such as “a person with a substance use disorder,” as a way to reduce stigma around addiction and resulting barriers to treatment. This study con
Externí odkaz:
https://doaj.org/article/5a0d9e6a5f324c439c5b095d37db3e22