Zobrazeno 1 - 8 of 8 pro vyhledávání: '"Connie Fan"'
1
Design and Characterization of a Pyridone-Containing EZH2 Inhibitor Phosphate Prodrug
Autor: Kephart Susan Elizabeth, Manfred Kraus, Hovhannes J. Gukasyan, Sutton Scott Channing, Joseph H Lee, Zehnder Luke Raymond, Shinji Yamazaki, Pei-Pei Kung, Buwen Huang, Connie Fan
Publikováno v: Journal of medicinal chemistry. 64(3)
A pyridone-derived phosphate prodrug of an enhancer of zeste homolog 2 (EZH2) inhibitor was designed and synthesized to improve the inhibitor's aqueous solubility. This prodrug (compound 5) was profiled in pharmacokinetic experiments to assess its ab
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f6a4fb2748542d3105ae4c3c1145472
https://pubmed.ncbi.nlm.nih.gov/33529029
Zobrazit plný text záznamu
2
Optimization of Orally Bioavailable Enhancer of Zeste Homolog 2 (EZH2) Inhibitors Using Ligand and Property-Based Design Strategies: Identification of Development Candidate (R)-5,8-Dichloro-7-(methoxy(oxetan-3-yl)methyl)-2-((4-methoxy-6-methyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-3,4-dihydroisoquinolin-1(2H)-one (PF-06821497)
Autor: Michael R. Collins, Robert Steven Kania, Connie Fan, Sutton Scott Channing, Dominique Verhelle, Kephart Susan Elizabeth, Martin James Wythes, Shuiwang Wang, Karen A. Maegley, Lisa Nguyen, Daniel Tyler Richter, A.E. Stewart, Pei-Pei Kung, Buwen Huang, Shikhar Sharma, Shinji Yamazaki, Ya-Li Deng, Rita Grantner, Patrick Bingham, Robert Arnold Kumpf, Penney Khamphavong, Jinjiang Zhu, Dac M. Dinh, Manfred Kraus, Wei Liu, Sean Uryu, Jillian E. Spangler, Wenyue Hu, Hui Wang, Robert A. Rollins, Cody Krivacic, Zehnder Luke Raymond, Neal W. Sach, Alexei Brooun, John Sherrill, Shijian Ren, Martin A. Edwards, Huichun Zhu, Ketan S. Gajiwala, Shuibo Xin, Hovhannes J. Gukasyan
Publikováno v: Journal of Medicinal Chemistry. 61:650-665
A new series of lactam-derived EZH2 inhibitors was designed via ligand-based and physicochemical-property-based strategies to address metabolic stability and thermodynamic solubility issues associated with previous lead compound 1. The new inhibitors
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f30f1b1d2d6acfd5a3cfe913d0c1179d
https://doi.org/10.1021/acs.jmedchem.7b01375
Zobrazit plný text záznamu
3
Optimization of Orally Bioavailable Enhancer of Zeste Homolog 2 (EZH2) Inhibitors Using Ligand and Property-Based Design Strategies: Identification of Development Candidate (R)-5,8-Dichloro-7-(methoxy(oxetan-3-yl)methyl)-2-((4-methoxy-6-methyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-3,4-dihydroisoquinolin-1(2H)-one (PF-06821497)
Autor: Pei-Pei, Kung, Patrick, Bingham, Alexei, Brooun, Michael, Collins, Ya-Li, Deng, Dac, Dinh, Connie, Fan, Ketan S, Gajiwala, Rita, Grantner, Hovhannes J, Gukasyan, Wenyue, Hu, Buwen, Huang, Robert, Kania, Susan E, Kephart, Cody, Krivacic, Robert A, Kumpf, Penney, Khamphavong, Manfred, Kraus, Wei, Liu, Karen A, Maegley, Lisa, Nguyen, Shijian, Ren, Dan, Richter, Robert A, Rollins, Neal, Sach, Shikhar, Sharma, John, Sherrill, Jillian, Spangler, Albert E, Stewart, Scott, Sutton, Sean, Uryu, Dominique, Verhelle, Hui, Wang, Shuiwang, Wang, Martin, Wythes, Shuibo, Xin, Shinji, Yamazaki, Huichun, Zhu, JinJiang, Zhu, Luke, Zehnder, Martin, Edwards
Publikováno v: Journal of medicinal chemistry. 61(3)
A new series of lactam-derived EZH2 inhibitors was designed via ligand-based and physicochemical-property-based strategies to address metabolic stability and thermodynamic solubility issues associated with previous lead compound 1. The new inhibitors
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::47b5a14cd255ea7adedb733daa3e1969
https://pubmed.ncbi.nlm.nih.gov/29211475
Zobrazit plný text záznamu
6
Generation of Destabilized Green Fluorescent Protein as a Transcription Reporter
Autor: Chiao-Chain Huang, Steven R. Kain, Connie Fan, Tommy Duong, Yu Fang, Xin Jiang, Xiaoning Zhao, Xianqiang Li
Publikováno v: Journal of Biological Chemistry. 273:34970-34975
The green fluorescent protein (GFP) is a widely used reporter in gene expression and protein localization studies. GFP is a stable protein; this property allows its accumulation and easy detection in cells. However, this stability also limits its app
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80493f950e87449b12872e180c396cdb
https://doi.org/10.1074/jbc.273.52.34970
Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání

Omezení vyhledávání
Plný text Recenzováno Digitální knihovna AV ČR
Zdroje