Výsledky vyhledávání - "Connie E. Kim"

Akademický článek

The nuclear envelope protein, LAP1B, is a novel protein phosphatase 1 substrate.

Autor: Mariana Santos, Sandra Rebelo, Paula J M Van Kleeff, Connie E Kim, William T Dauer, Margarida Fardilha, Odete A da Cruz E Silva, Edgar F da Cruz E Silva

Publikováno v: PLoS ONE, Vol 8, Iss 10, p e76788 (2013)

Protein phosphatase 1 (PP1) binding proteins are quintessential regulators, determining substrate specificity and defining subcellular localization and activity of the latter. Here, we describe a novel PP1 binding protein, the nuclear membrane protei

Externí odkaz: https://doaj.org/article/aa03d26da1d141e18470d8003e4c191a

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Primary dystonia: molecules and mechanisms

Autor: Connie E. Kim, William T. Dauer, Noga Alagem, Lauren M. Tanabe

Publikováno v: Nature Reviews Neurology. 5:598-609

Primary dystonia is characterized by involuntary twisting and turning movements that occur in the absence of overt brain lesions or evidence of neurodegeneration. As Tanabe et al. discuss in this article, advances in structural and functional imaging

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0933aa057748d82f749a6668905f560
https://doi.org/10.1038/nrneurol.2009.160

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Investigating Single Nucleotide Polymorphisms In MiRNA-Binding Sites In The K-RAS 3' Untranslated Region As A Novel Biomarker For Lung Cancer

Autor: Connie E. Kim, William N. Rom, Kam-Meng Tchou-Wong

Publikováno v: D78. PATHWAYS AND MODELS OF LUNG ONCOGENESIS.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ecae0caccbf7fba2166f12ed2837bfcd
https://doi.org/10.1164/ajrccm-conference.2012.185.1_meetingabstracts.a6349

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Sputum-based molecular biomarkers for the early detection of lung cancer: limitations and promise

Autor: William N. Rom, Connie E. Kim, Kam-Meng Tchou-Wong

Publikováno v: Cancers
Cancers, Vol 3, Iss 3, Pp 2975-2989 (2011)

Lung cancer is the leading cause of cancer deaths, with an overall survival of 15% at five years. Biomarkers that can sensitively and specifically detect lung cancer at early stage are crucial for improving this poor survival rate. Sputum has been th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2be1cc31345a0bec7fdfcfd6e1272853
https://pubmed.ncbi.nlm.nih.gov/24212941

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Detection Of Mutations In A Panel Of Genes To Identify Sputum-Based Biomarkers For Early Diagnosis Of Lung Cancer Among High-Risk Smokers

Autor: Kam-Meng Tchou-Wong, William N. Rom, Connie E. Kim

Publikováno v: C69. LUNG CANCER BIOMARKERS.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e06732f4fd31e5099031689973444609
https://doi.org/10.1164/ajrccm-conference.2011.183.1_meetingabstracts.a5145

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A molecular mechanism underlying the neural-specific defect in torsinA mutant mice

Autor: Guy Perkins, Connie E. Kim, William T. Dauer, Alex Perez, Mark H. Ellisman

A striking but poorly understood feature of many diseases is the unique involvement of neural tissue. One example is the CNS-specific disorder DYT1 dystonia, caused by a 3-bp deletion (“ΔE”) in the widely expressed gene TOR1A . Disease mutant kn

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::458fe8dab70abf9b04ef47ff7fe68d0a
https://europepmc.org/articles/PMC2906867/

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Loss of the dystonia-associated protein torsinA selectively disrupts the neuronal nuclear envelope

Autor: Rose E. Goodchild, William T. Dauer, Connie E. Kim

Publikováno v: Neuron. 48(6)

Summary An enigmatic feature of many genetic diseases is that mutations in widely expressed genes cause tissue-specific illness. One example is DYT1 dystonia, a neurodevelopmental disease caused by an in-frame deletion (Δgag) in the gene encoding to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::779aac5654db9082dba8043909ad60ca
https://pubmed.ncbi.nlm.nih.gov/16364891

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CTNNB1 Mutations and Overexpression of Wnt/β-Catenin Target Genes in WT1-Mutant Wilms’ Tumors

Autor: Vivette D. D'Agati, Jonathan D. Licht, Benjamin Tycko, Connie E. Kim, Vundavalli V. Murty, Chi Ming Li, Jacqueline M. Mason, Paul E. Grundy, Eric R. Fearon, Adam A. Margolin, Terrence Hensle, Meirong Guo, Jimmy Zhu

Gain-of-function mutations in exon 3 of beta-catenin (CTNNB1) are specific for Wilms' tumors that have lost WT1, but 50% of WT1-mutant cases lack such "hot spot" mutations. To ask whether stabilization of beta-catenin might be essential after WT1 los

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::daa9c30faf34b803fa02d7ac2d808d00
https://europepmc.org/articles/PMC1618727/

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The Nuclear Envelope Protein, LAP1B, Is a Novel Protein Phosphatase 1 Substrate

Autor: Paula J. M. van Kleeff, Sandra Rebelo, Connie E. Kim, Margarida Fardilha, Edgar F. da Cruz e Silva, William T. Dauer, Mariana Santos, Odete A. da Cruz e Silva

Publikováno v: research@ua; Vol 4 (2013); 30
research@ua; vol. 4 (2013); 30
Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
PLoS ONE
PLoS ONE, Vol 8, Iss 10, p e76788 (2013)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa609ce92c856440dc7b0ecdad12e7a5
https://doi.org/10.1371/journal.pone.0076788

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