Evaluation of the IgG antibody response to SARS CoV-2 infection and performance of a lateral flow immunoassay: cross-sectional and longitudinal analysis over 11 months

Autor: David Hunter, Peter Sharpe, Louise J Robertson, Julie S Moore, Kevin Blighe, Kok Yew Ng, Nigel Quinn, Fergal Jennings, Gary Warnock, Mark Clarke, Kathryn Maguire, Sharon Rainey, Ruth K Price, William P Burns, Amanda M Kowalczyk, Agnes Awuah, Sara E McNamee, Gayle E Wallace, Steve Sager, Connie Chao Shern, M Andrew Nesbit, James A D McLaughlin, Tara Moore

Publikováno v: BMJ Open, Vol 11, Iss 6 (2021)

Objective To evaluate the dynamics and longevity of the humoral immune response to SARS-CoV-2 infection and assess the performance of professional use of the UK-RTC AbC-19 Rapid Test lateral flow immunoassay (LFIA) for the target condition of SARS-Co

Externí odkaz: https://doaj.org/article/b61885bf745747f4952d53045ee0aca1

Abstract 6597: A multi-omics classifier achieves high sensitivity and specificity for pancreatic ductal adenocarcinoma in a case-control study of 146 subjects

Autor: John Blume, Ghristine Bundalian, Jessica Chan, Connie Chao-Shern, Jinlyung Choi, Rea Cuaresma, Kevin Dai, Sara N. Golmaei, Jun Heok Jang, Manoj Khadka, Ehdieh Khaledian, Thidar Khin, Yuya Kodama, Ajinkya Kokate, Joon-Yong Lee, Manway Liu, Hoda Malekpour, Megan Mora, Nithya Mudaliar, Preethi Prasad, Madhuvanthi Ramaiah, Saividya Ramaswamy, Peter Spiro, Kavya Swaminathan, Dijana Vitko, James Yee, Brian Young, Susan Zhang, Chinmay Belthangady, Bruce Wilcox, Brian Koh, Philip Ma

Publikováno v: Cancer Research. 83:6597-6597

Pancreatic ductal adenocarcinoma (PDAC) is currently the 3rd leading cause of cancer-related deaths in the US. Although the all-stage 5-year survival rate is ~10%, early-stage 5-year survival is markedly superior and in excess of 40%. Hence, early de

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c1caa425e30facfbfde40be36ae5fe1f
https://doi.org/10.1158/1538-7445.am2023-6597

Abstract A038: High-dimensional, multi-omics analyses of proteins, metabolites, transcripts, and genes enable biomarker discovery in early- and late-stage pancreatic cancer

Autor: Ehdieh Khaledian, Preethi Prasad, John Blume, Ghristine Bundalian, Connie Chao-Shern, Jinlyung Choi, Rea Cuaresma, Jared Deyarmin, Jun Heok Jang, Manoj Khadka, Thidar Khin, Yuya Kodama, Ajinkya Kokate, Joon-Yong Lee, Manway Liu, Nithya Mudaliar, Madhuvanthi Ramaiah, Saividya Ramaswamy, Peter Spiro, Kavya Swaminathan, Preston Williams, Mi Yang, James Yee, Brian Young, Robert Zawada, Susan Zhang, Chinmay Belthangady, Bruce Wilcox, Philip Ma

Publikováno v: Cancer Research. 82:A038-A038

Pancreatic cancer is the third leading cause of cancer-related deaths in the United States. Disease biomarkers quantified from blood-based assays may help reduce mortality by enabling early detection, treatment selection, or response and resistance a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0f3f28083eff9a445a099272caf4f3c9
https://doi.org/10.1158/1538-7445.panca22-a038

Evaluation of TGFBI corneal dystrophy and molecular diagnostic testing

Autor: Kathleen A. Christie, Vance Thompson, Lawrence A. DeDionisio, M. Andrew Nesbit, C. B. Tara McMullen, Connie Chao-Shern, Jun-Heok Jang, Clara C. Chan

Publikováno v: Eye

To date, 70 different TGFBI mutations that cause epithelial-stromal corneal dystrophies have been described. At present one commercially available test examines for the five most common of these mutations: R124H, R124C, R124L, R555W, and R555Q. To ex

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8bf838958bddbb5c52d7ff2323e9b6d4
https://doi.org/10.1038/s41433-019-0346-x

Biochemical mechanisms of aggregation in TGFBI-linked corneal dystrophies

Autor: Jesper Hjortdal, Jan J. Enghild, Emilie Hage Mogensen, Christian E. Weberskov, Nadia Sukusu Nielsen, Leif Schauser, Connie Chao Shern, Larry DeDionisio, Marie V. Lukassen, Tara Moore, Daniel E. Otzen, Ebbe Toftgaard Poulsen

Publikováno v: Nielsen, N S, Poulsen, E T, Lukassen, M V, Chao Shern, C, Mogensen, E H, Weberskov, C E, DeDionisio, L, Schauser, L, Moore, T C B, Otzen, D E, Hjortdal, J & Enghild, J J 2020, ' Biochemical mechanisms of aggregation in TGFBI-linked corneal dystrophies ', Progress in Retinal and Eye Research, vol. 77, 100843 . https://doi.org/10.1016/j.preteyeres.2020.100843

Transforming growth factor-β-induced protein (TGFBIp), an extracellular matrix protein, is the second most abundant protein in the corneal stroma. In this review, we summarize the current knowledge concerning the expression, molecular structure, bin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90a2fd739da5eb26bc6495d3870af25c
https://pure.au.dk/portal/da/publications/biochemical-mechanisms-of-aggregation-in-tgfbilinked-corneal-dystrophies(576a837b-eb14-4f60-ae13-c5820163b8a8).html