Zobrazeno 1 - 10
of 37
pro vyhledávání: '"Connell Richard D"'
Autor:
Jean S. Beebe, William M. Hungerford, Nandini Chaturbhai Patel, Heather N. Frost, Susan Deborah Lagreca, Cathy Soderstrom, Shefali Kakar, Doug Savage, Matthew David Wessel, Matthew A. Marx, Merin Boehm, Thompson Carl Brian, Jinshan M. Chen, Connell Richard D, Nandell F. Keene, Elizabeth Knauth, Gary Borzillo, Aaron Kanter, Yong Lu, Joel Morris, Martin A. Berliner, Patrick Vincent, Bruce D. Cohen, George T. Tkalcevic, Joel T. Arcari, Deborah A. Gordon, James J. Valentine, Tracey Clark, Louis Martinez-Alsina, Vincent Bernardo, Felix Vajdos, Norma Jacqueline Tom
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 23:3059-3063
The synthesis and biological evaluation of novel Tie-2 kinase inhibitors are presented. Based on the pyrrolopyrimidine chemotype, several new series are described, including the benzimidazole series by linking a benzimidazole to the C5-position of th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4094fb50746e9612e49cef7a5bc7bf6
https://doi.org/10.1016/j.bmcl.2013.03.012
https://doi.org/10.1016/j.bmcl.2013.03.012
Autor:
Connell Richard D
Publikováno v:
Expert Opinion on Therapeutic Patents. 14:1763-1771
Gefitinib (Iressa®, AstraZeneca) was the first quinazoline-based kinase inhibitor to be approved for the treatment of cancer. This article traces the patent filings related to gefitinib that form the basis of the AstraZeneca patent estate surroundin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bba0aa4bb473dbb1509a1059462de5a7
https://doi.org/10.1517/13543776.14.12.1763
https://doi.org/10.1517/13543776.14.12.1763
Autor:
Connell Richard D
Publikováno v:
Expert Opinion on Therapeutic Patents. 13:737-749
Indol-2-ones or 2-oxoindole-based tyrosine kinase inhibitors (TKIs) were originally identified in the late 1980s by researchers in Japan and Italy. Interest in this series of TKIs increased significantly following the disclosure of SU5416, a clinical
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6358183d68fc574a51c82dd0ad120049
https://doi.org/10.1517/13543776.13.6.737
https://doi.org/10.1517/13543776.13.6.737
Autor:
Connell Richard D
Publikováno v:
Expert Opinion on Therapeutic Patents. 12:1763-1782
Angiogenesis refers to the formation of new capillaries from existing blood vessels and is believed to be a key process in tumour growth. Angiogenesis inhibition represents an active area of cancer drug discovery, with several agents and approaches n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5da8c5a2ec86669614e876b223029653
https://doi.org/10.1517/13543776.12.12.1763
https://doi.org/10.1517/13543776.12.12.1763
Autor:
Connell Richard D, Jean S. Beebe
Publikováno v:
Expert Opinion on Therapeutic Patents. 11:1919-1945
Angiogenesis refers to the formation of capillary blood vessels from existing blood vessels: a process that is believed to be a key driver in cancer growth and metastasis. Angiogenesis inhibition represents an active area of cancer drug discovery, wi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f7a383e93b82a1545f64ba78281c7dcf
https://doi.org/10.1517/13543776.11.12.1919
https://doi.org/10.1517/13543776.11.12.1919
Autor:
Jean S. Beebe, Connell Richard D
Publikováno v:
Expert Opinion on Therapeutic Patents. 11:1171-1203
Angiogenesis refers to the formation of new blood vessels from existing blood vessels, a process that is believed to be a key requirement for tumour growth and metastasis. Angiogenesis inhibition represents a new approach to cancer chemotherapy and s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4571f1b873e302feca3b53d85104c29b
https://doi.org/10.1517/13543776.11.7.1171
https://doi.org/10.1517/13543776.11.7.1171
Autor:
Jean S. Beebe, Connell Richard D
Publikováno v:
Expert Opinion on Therapeutic Patents. 11:77-114
Angiogenesis refers to the formation of capillary blood vessels from existing blood vessels: a process that is believed to be critical for tumour growth and metastasis. Angiogenesis inhibition represents a new approach to cancer chemotherapy with sev
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::298487adc688e4e511c89596f73eca33
https://doi.org/10.1517/13543776.11.1.77
https://doi.org/10.1517/13543776.11.1.77
Autor:
Connell Richard D
Publikováno v:
Expert Opinion on Therapeutic Patents. 10:767-786
Angiogenesis is often defined as the formation of capillary blood vessels from existing blood vessels. In the area of cancer research, approaches that seek to block angiogenesis are under intense investigation. In the past six months, a number of app
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a8fa2ed3cc7737d7eee621b48c8e3887
https://doi.org/10.1517/13543776.10.6.767
https://doi.org/10.1517/13543776.10.6.767
Autor:
Connell Richard D
Publikováno v:
Expert Opinion on Therapeutic Patents. 9:701-709
Insulin and glucagon are the primary agents responsible for ensuring acute and long-term maintenance of glucose levels in the blood. There is strong evidence that excessive glucagon levels contribute to the hyperglycaemia of non-insulin dependent dia
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::14bcffd62264f734de4dcd2fbcefcd33
https://doi.org/10.1517/13543776.9.6.701
https://doi.org/10.1517/13543776.9.6.701
Autor:
Arcari, Joel T., Beebe, Jean S., Berliner, Martin A., Bernardo, Vincent, Boehm, Merin, Borzillo, Gary V., Clark, Tracey, Cohen, Bruce D., Connell, Richard D., Frost, Heather N., Gordon, Deborah A., Hungerford, William M., Kakar, Shefali M., Kanter, Aaron, Keene, Nandell F., Knauth, Elizabeth A., LaGreca, Susan D., Lu, Yong, Martinez-Alsina, Louis, Marx, Matthew A., Morris, Joel, Patel, Nandini C., Savage, Doug, Soderstrom, Cathy I., Thompson, Carl, Tkalcevic, George, Tom, Norma J., Vajdos, Felix F., Valentine, James J., Vincent, Patrick W., Wessel, Matthew D., Chen, Jinshan M.
Publikováno v:
In Bioorganic & Medicinal Chemistry Letters 15 May 2013 23(10):3059-3063