Alpha-synuclein pre-formed fibrils injected into prefrontal cortex primarily impact cortical and subcortical structures and lead to restricted behavioral impacts

Autor: Weber, Matthew A., de Choisy, Gemma, Thangavel, Ramasamy, Conlon, Mackenzie M., Abdelmotilib, Hisham A., Halhouli, Oday, Zhang, Qiang, Geerling, Joel C., Narayanan, Nandakumar S., Aldridge, Georgina M.

Publikováno v: bioRxiv

Parkinson ‘s disease dementia (PDD) and Lewy Body dementia (LBD) are characterized by diffuse spread of alpha-synuclein (α-syn) throughout the brain. These patients have a neuropsychological pattern of deficits that include executive dysfunction,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::a66aea3b78cdc9803418d46fed65271b
https://europepmc.org/articles/PMC9915664/

7.4 Adolescent Pesticide Exposure and ADHD Risk: Mechanisms of Immediate Effect and Long-Term Vulnerability

Autor: Stevens, Hanna, Doorn, Jonathan, Conlon, Mackenzie M., Taylor, Robert J., Lehmler, Hans-Joachim

Publikováno v: In Journal of the American Academy of Child & Adolescent Psychiatry October 2022 61(10) Supplement:S288-S288

Alpha-synuclein pre-formed fibrils injected into prefrontal cortex primarily spread to cortical and subcortical structures and lead to isolated behavioral symptoms.

Autor: Weber MA; Department of Neurology, Carver College of Medicine, University of Iowa, Iowa City., Kerr G; Department of Neurology, Carver College of Medicine, University of Iowa, Iowa City., Thangavel R; Department of Neurology, Carver College of Medicine, University of Iowa, Iowa City., Conlon MM; Medical Scientist Training Program, Carver College of Medicine, University of Iowa, Iowa City., Abdelmotilib HA; Department of Neurology, Carver College of Medicine, University of Iowa, Iowa City., Halhouli O; Department of Neurology, Carver College of Medicine, University of Iowa, Iowa City., Zhang Q; Department of Neurology, Carver College of Medicine, University of Iowa, Iowa City., Geerling JC; Department of Neurology, Carver College of Medicine, University of Iowa, Iowa City., Narayanan NS; Department of Neurology, Carver College of Medicine, University of Iowa, Iowa City., Aldridge GM; Department of Neurology, Carver College of Medicine, University of Iowa, Iowa City.

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2023 May 15. Date of Electronic Publication: 2023 May 15.