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Restoring hippocampal glucose metabolism rescues cognition across Alzheimer's disease pathologies.

Autor: Minhas PS; Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA, 94305, USA.; Wu Tsai Neurosciences Institute, Stanford University, Stanford, CA 94305, USA., Jones JR; Laboratory of Genetics, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA., Latif-Hernandez A; Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA, 94305, USA., Sugiura Y; Central Institute for Experimental Medicine and Life Science, Keio University, 3-25-12 Tonomachi, Kawasaki-ku, Kawasaki 210-0821, Japan.; WPI-Bio2Q Research Center, Keio University, 3-25-12 Tonomachi, Kawasaki-ku, Kawasaki 210-0821 Japan.; Center for Cancer Immunotherapy and Immunobiology, Kyoto University Graduate School of Medicine, Kyoto 606-8501, Japan., Durairaj AS; Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA, 94305, USA., Wang Q; Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA, 94305, USA., Mhatre SD; Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA, 94305, USA., Uenaka T; Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA., Crapser J; Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA, 94305, USA., Conley T; Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA, 94305, USA., Ennerfelt H; Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA, 94305, USA., Jung YJ; Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA, 94305, USA., Liu L; Lewis Institute for Cancer Research, Princeton University, Princeton, NJ 08544, USA.; Department of Chemistry, Princeton University, Princeton 08544 NJ, USA., Prasad P; Department of Biochemistry and Molecular Biology, Huck Institutes of the Life Sciences, Pennsylvania State University, University Park, PA 16802, USA., Jenkins BC; Department of Biochemistry and Molecular Biology, Huck Institutes of the Life Sciences, Pennsylvania State University, University Park, PA 16802, USA., Ay YA; Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA, 94305, USA., Matrongolo M; Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA, 94305, USA., Goodman R; Laboratory of Genetics, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA., Newmeyer T; Laboratory of Genetics, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA., Heard K; Laboratory of Genetics, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA., Kang A; Laboratory of Genetics, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA., Wilson EN; Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA, 94305, USA., Yang T; Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA, 94305, USA., Ullian EM; Department of Ophthalmology, University of California, San Francisco, San Francisco, CA 94143, USA., Serrano GE; Civin Laboratory for Neuropathology, Banner Sun Health Research Institute, Sun City, AZ 85351, USA., Beach TG; Civin Laboratory for Neuropathology, Banner Sun Health Research Institute, Sun City, AZ 85351, USA., Wernig M; Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA.; Department of Chemical and Systems Biology, Stanford University, Stanford, CA 94305, USA., Rabinowitz JD; Lewis Institute for Cancer Research, Princeton University, Princeton, NJ 08544, USA.; Department of Chemistry, Princeton University, Princeton 08544 NJ, USA., Suematsu M; Central Institute for Experimental Medicine and Life Science, Keio University, 3-25-12 Tonomachi, Kawasaki-ku, Kawasaki 210-0821, Japan.; WPI-Bio2Q Research Center, Keio University, 3-25-12 Tonomachi, Kawasaki-ku, Kawasaki 210-0821 Japan., Longo FM; Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA, 94305, USA.; Wu Tsai Neurosciences Institute, Stanford University, Stanford, CA 94305, USA., McReynolds MR; Lewis Institute for Cancer Research, Princeton University, Princeton, NJ 08544, USA.; Department of Chemistry, Princeton University, Princeton 08544 NJ, USA.; Department of Biochemistry and Molecular Biology, Huck Institutes of the Life Sciences, Pennsylvania State University, University Park, PA 16802, USA., Gage FH; Laboratory of Genetics, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA., Andreasson KI; Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA, 94305, USA.; Wu Tsai Neurosciences Institute, Stanford University, Stanford, CA 94305, USA.; Chan Zuckerberg Biohub, San Francisco, CA 94158, USA.; The Phil and Penny Knight Initiative for Brain Resilience at the Wu Tsai Neurosciences Institute, Stanford University, CA 94305, USA.

Publikováno v: Science (New York, N.Y.) [Science] 2024 Aug 23; Vol. 385 (6711), pp. eabm6131. Date of Electronic Publication: 2024 Aug 23.

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