Zobrazeno 1 - 10
of 50
pro vyhledávání: '"Congrong Ma"'
Publikováno v:
Molecular Therapy: Oncolytics, Vol 17, Iss , Pp 350-360 (2020)
Successful in situ therapeutic vaccination would allow locally delivered oncolytic virus (OV) to exert systemic immunologic effects on metastases and improve survival. We have utilized bilateral flank tumor models to determine the most efficacious re
Externí odkaz:
https://doaj.org/article/e97e2186645e413e848c73adf5e79d7d
Autor:
Weilin Liu, Hongqi Chen, Zhi Zhu, Zuqiang Liu, Congrong Ma, Yong J. Lee, David L. Bartlett, Zong-Sheng Guo
Publikováno v:
Biomedicines, Vol 10, Iss 6, p 1425 (2022)
Ferroptosis is a type of programmed cell death dependent on iron and characterized by the accumulation of lipid peroxides. In this study, we explore the combination of a ferroptosis activator with an oncolytic vaccinia virus in tumor models. Erastin
Externí odkaz:
https://doaj.org/article/845fcbfbe9d346f2adef10925b7e5237
Autor:
Esther Giehl, Hiromichi Kosaka, Zuqiang Liu, Mathilde Feist, Udai S. Kammula, Michael T. Lotze, Congrong Ma, Zong Sheng Guo, David L. Bartlett
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Adoptive cell therapy (ACT) using autologous tumor infiltrating lymphocytes (TIL) achieves durable clinical benefit for patients from whom these cells can be derived in advanced metastatic melanoma but is limited in most solid tumors as a result of i
Externí odkaz:
https://doaj.org/article/525f6f107eda4fd488a555127d5b674c
Autor:
Zuqiang Liu, Yan Ge, Haiyan Wang, Congrong Ma, Mathilde Feist, Songguang Ju, Z. Sheng Guo, David L. Bartlett
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-9 (2018)
IL-2 is used systemically for cancer therapy but it is associated with severe toxicity. Here, the authors design a recombinant vaccinia virus expressing membrane-bound IL-2 that shows therapeutic efficacy alone or in combination with checkpoint inhib
Externí odkaz:
https://doaj.org/article/bf8c62b2e7b9492694731295e94b4d6e
Autor:
Yan Ge, Enyong Dai, Weilin Liu, Zuqiang Liu, Haiyan Wang, Jinghua Ren, Lingjuan Chen, Hongqi Chen, Congrong Ma, Songguang Ju
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 8, Iss 1 (2020)
Immune checkpoint blockade is arguably the most effective current cancer therapy approach; however, its efficacy is limited to patients with “hot” tumors, warranting an effective approach to transform “cold” tumors. Oncolytic viruses (especia
Externí odkaz:
https://doaj.org/article/7cea4f5916d54791aead8e66d2c50f42
Autor:
Matthew D Neal, Hongpeng Jia, Benjamin Eyer, Misty Good, Christopher J Guerriero, Chhinder P Sodhi, Amin Afrazi, Thomas Prindle, Congrong Ma, Maria Branca, John Ozolek, Jeffrey L Brodsky, Peter Wipf, David J Hackam
Publikováno v:
PLoS ONE, Vol 8, Iss 6, p e65779 (2013)
Many inflammatory diseases may be linked to pathologically elevated signaling via the receptor for lipopolysaccharide (LPS), toll-like receptor 4 (TLR4). There has thus been great interest in the discovery of TLR4 inhibitors as potential anti-inflamm
Externí odkaz:
https://doaj.org/article/7ac61acca89f407e9b1fd71db80e98bf
Autor:
Mathilde Feist, Zong Sheng Guo, Min Yang, Zuqiang Liu, Hongqi Chen, Congrong Ma, Binfeng Lu, Roshni Ravindranathan, Enyong Dai, David L. Bartlett, Chao Feng, Esther Giehl
Publikováno v:
Cancer Immunology, Immunotherapy
In this study, we aimed to apply the cytokine IL-36γ to cancer immunotherapy by constructing new oncolytic vaccinia viruses (OV) expressing interleukin-36γ (IL-36γ-OVs), leveraging unique synergism between OV and IL-36γ’s ability to promote ant
Autor:
Yan Ge, Jinghua Ren, Weilin Liu, Hongqi Chen, Congrong Ma, David L. Bartlett, Junjie Ye, Enyong Dai, Haiyan Wang, Zuqiang Liu, Lingjuan Chen, Songguang Ju, Z. Sheng Guo
Publikováno v:
Theranostics
Background: Newly emerging cancer immunotherapy has led to significant progress in cancer treatment; however, its efficacy is limited in solid tumors since the majority of them are “cold” tumors. Oncolytic viruses, especially when properly armed,
Autor:
Nataša Obermajer, Udai S. Kammula, Michael T. Lotze, Zong Sheng Guo, David L. Bartlett, Roshni Ravindranathan, Andrew J. Lee, Congrong Ma, Zuqiang Liu, Enyong Dai, Zhi Zhu, Mathilde Feist, Stacy J. Kowalsky, Esther Giehl
Publikováno v:
Cancer Gene Therapy. 28:98-111
Adoptive cell therapy (ACT) using tumor-specific tumor-infiltrating lymphocytes (TILs) has demonstrated success in patients where tumor-antigen specific TILs can be harvested from the tumor, expanded, and re-infused in combination with a preparatory
Publikováno v:
Molecular Therapy Oncolytics
Molecular Therapy: Oncolytics, Vol 17, Iss, Pp 350-360 (2020)
Molecular Therapy: Oncolytics, Vol 17, Iss, Pp 350-360 (2020)
Successful in situ therapeutic vaccination would allow locally delivered oncolytic virus (OV) to exert systemic immunologic effects on metastases and improve survival. We have utilized bilateral flank tumor models to determine the most efficacious re