Zobrazeno 1 - 10
of 80
pro vyhledávání: '"Congran Li"'
Autor:
Xinyi Yang, Congran Li, Xiukun Wang, Zhonghui Zheng, Peiyi Sun, Chunjie Xu, Luni Chen, Jiandong Jiang, Staffan Normark, Birgitta Henriques-Normark, Xuefu You
Publikováno v:
Engineering, Vol 38, Iss , Pp 52-68 (2024)
Antibacterial resistance is a global health threat that requires further concrete action on the part of all countries. In this context, one of the biggest concerns is whether enough new antibacterial drugs are being discovered and developed. Although
Externí odkaz:
https://doaj.org/article/efd940f3eba44a6fa60aefb262ea8f1d
Publikováno v:
Frontiers in Microbiology, Vol 15 (2024)
IntroductionMycobacterium tuberculosis (Mtb), the main cause of tuberculosis (TB), has brought a great burden to the world's public health. With the widespread use of Mtb drug-resistant strains, the pressure on anti-TB treatment is increasing. Anti-T
Externí odkaz:
https://doaj.org/article/6d8340d8486840c79140cbd50bd89f3f
Autor:
Haibin Li, Lang Sun, Han Qiao, Zongti Sun, Penghe Wang, Chunyang Xie, Xinxin Hu, Tongying Nie, Xinyi Yang, Guoqing Li, Youwen Zhang, Xiukun Wang, Zhuorong Li, Jiandong Jiang, Congran Li, Xuefu You
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 13, Iss 9, Pp 3678-3693 (2023)
Polymyxin B and polymyxin E (colistin) are presently considered the last line of defense against human infections caused by multidrug-resistant Gram-negative organisms such as carbapenemase-producer Enterobacterales, Acinetobacter baumannii, and Kleb
Externí odkaz:
https://doaj.org/article/4b236b4d713440a59894dac70c6e0d3f
Autor:
Chunyang Xie, Penghe Wang, Huige Wu, Xinxin Hu, Tongying Nie, Xue Li, Pengbo Pang, Guoqing Li, Yun Lu, Xinyi Yang, Xiukun Wang, Congran Li, Xuefu You
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 164, Iss , Pp 114965- (2023)
Background: Sepsis has become a global health concern owing to its increasing incidence and high mortality rate. In the present study, we investigated a novel drug candidate ASK0912 on its protective effects in mice with Acinetobacter baumannii 20–
Externí odkaz:
https://doaj.org/article/1d5a79f45a324376b5118487d007aded
Autor:
Xi Lu, Yanxiang Wang, Wei Guo, Zhimeng Zhang, Xinxin Hu, Tongying Nie, Xinyi Yang, Congran Li, Xiukun Wang, Xue Li, Yun Lu, Guoqing Li, Youwen Zhang, Lang Sun, Jing Pang, Xuefu You
Publikováno v:
Microbiology Spectrum, Vol 11, Iss 1 (2023)
ABSTRACT Enterococci can cause various infectious diseases, including urinary tract infection, wound infection, and life-threatening endocarditis and meningitis. The emergence and transmission of vancomycin-resistant enterococci (VRE) have presented
Externí odkaz:
https://doaj.org/article/733cc821b91a45b9a2ba6b6d7f33208b
Publikováno v:
Microbiology Spectrum, Vol 10, Iss 5 (2022)
ABSTRACT To study the effect of different tolerable levels of constitutive mcr-1 expression on Escherichia coli, and to provide direct evidence for moderate resistance mediated by mcr-1, construction of E. coli strains carrying mcr-1 on the chromosom
Externí odkaz:
https://doaj.org/article/5f10aa174ff84be2a6ac0216cf472a6e
Autor:
Hongtong Chen, Chengqi Yu, Han Wu, Guoqing Li, Congran Li, Wei Hong, Xinyi Yang, Hao Wang, Xuefu You
Publikováno v:
Frontiers in Chemistry, Vol 10 (2022)
The prevalence of antimicrobial-resistant pathogens significantly limited the number of effective antibiotics available clinically, which urgently requires new drug targets to screen, design, and develop novel antibacterial drugs. Two-component syste
Externí odkaz:
https://doaj.org/article/10f2298d8e074447a1da70740e123608
Publikováno v:
Frontiers in Microbiology, Vol 13 (2022)
The increasing spread of drug-resistant bacterial strains presents great challenges to clinical antibacterial treatment and public health, particularly with regard to β-lactamase-producing Enterobacteriaceae. A rapid and accurate detection method th
Externí odkaz:
https://doaj.org/article/944d232df33448bab75cd0fe454d0b56
Autor:
Limin Dong, Jing Pang, Xiukun Wang, Youwen Zhang, Guoqing Li, Xinxin Hu, Xinyi Yang, Chung-Dar Lu, Congran Li, Xuefu You
Publikováno v:
Virulence, Vol 11, Iss 1, Pp 57-67 (2020)
MvaT and MvaU are global transcriptional regulators belonging to the H-NS family, and pyocyanin is an important virulence factor produced by Pseudomonas aeruginosa. mvaT mvaU double knockout mutant of P. aeruginosa PAO1 demonstrated pyocyanin abolish
Externí odkaz:
https://doaj.org/article/ce081bb56dc649619eeeb22fbab47e6b
Autor:
Xue Li, Penghe Wang, Xinxin Hu, Youwen Zhang, Xi Lu, Congran Li, Tongying Nie, Guoqing Li, Xiukun Wang, Jing Pang, Yun Lu, Xinyi Yang, Xuefu You
Publikováno v:
BMC Microbiology, Vol 20, Iss 1, Pp 1-11 (2020)
Abstract Background Infections caused by drug-resistant Staphylococcus aureus, especially vancomycin-intermediate Staphylococcus aureus (VISA), leave clinicians with limited therapeutic options for treatment. Persister cells is a leading cause of rec
Externí odkaz:
https://doaj.org/article/9a92196bf1b94506b111819e0f888503