Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Congmin, Yuan"'
Autor:
Tianfu Zhang, Xiaoyu Chen, Congmin Yuan, Xiaobin Pang, Ping Shangguan, Yisheng Liu, Lulu Han, Jianwei Sun, Jacky W. Y. Lam, Yang Liu, Jiefei Wang, Bingyang Shi, Ben Zhong Tang
Publikováno v:
Angewandte Chemie (International ed. in English). 62(2)
Optimized theranostic strategies for Alzheimer's disease (AD) remain almost absent from bench to clinic. Current probes and drugs attempting to prevent β-amyloid (Aβ) fibrosis encounter failures due to the blood-brain barrier (BBB) penetration chal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::101ea7732b6c3c48e68c7885093cd370
https://pubmed.ncbi.nlm.nih.gov/36336656
https://pubmed.ncbi.nlm.nih.gov/36336656
Autor:
Jing-Gen Liu, Xiangguo Meng, Jing Liu, Wenli Wang, Huoming Huang, Jing-Rui Chai, Jing Chen, Wei Li, Xue-Ping Li, Congmin Yuan, Wei Fu, Xinwei Li, Xue-Jun Xu, Peng Xie, Yujun Wang, Yuanyuan Qian
Publikováno v:
Journal of Medicinal Chemistry. 64:9458-9483
Management of moderate to severe pain relies heavily on opioid analgesics such as morphine, oxycodone, and fentanyl in clinics. However, their prolonged use was associated with undesirable side effects. Many new strategies to reduce side effects have
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7f906863e262826f49cc9db2fb0b05e0
https://doi.org/10.1021/acs.jmedchem.1c00722
https://doi.org/10.1021/acs.jmedchem.1c00722
Publikováno v:
Physical Chemistry Chemical Physics. 23:20117-20128
The ongoing pandemic caused by SARS-CoV-2 emphasizes the need for effective therapeutics. Inhibition of SARS-CoV-2 RNA-dependent RNA polymerase (RdRp) by nucleotide analogs provides a promising antiviral strategy. One common group of RdRp inhibitors,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6881828e31a9989821f6ebef9dcae80f
https://doi.org/10.1039/d1cp03049c
https://doi.org/10.1039/d1cp03049c
Autor:
Peter Pak-Hang Cheung, Dong Zhang, Lu Zhang, Yongfang Li, Xilin Jia, Xin Gao, Xiaowei Wang, Xuhui Huang, Congmin Yuan, Hui-Ling Yen
Publikováno v:
Physical Chemistry Chemical Physics. 23:5852-5863
COVID-19 has recently caused a global health crisis and an effective interventional therapy is urgently needed. Remdesivir is one effective inhibitor for SARS-CoV-2 viral RNA replication. It supersedes other NTP analogues because it not only terminat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e28b1f50495f0c5ae0307ddfbc7da3f
https://doi.org/10.1039/d0cp05948j
https://doi.org/10.1039/d0cp05948j
Publikováno v:
Molecules, Vol 23, Iss 12, p 3181 (2018)
As an attractive drug-target, retinoic acid receptor-related orphan receptor-gamma-t (RORγt) has been employed widely to develop clinically relevant small molecular modulators as potent therapy for autoimmune disease and cancer, but its molecular me
Externí odkaz:
https://doaj.org/article/8f4d781fa4404351b1e8b0ce221890d7
Autor:
Yuanyuan Qian, Yilin Zheng, Lan Zheng, Xicheng Yang, Wei Li, Xue-Jun Xu, Mumei Zhang, Qian He, Huoming Huang, Xiao Liu, Ru-Feng Ye, Zhuibai Qiu, Congmin Yuan, Cheng Lin, Hao Chen, Rongrong Ye, Shuang Jiang, Huijiao Sun, Linqian Yu, Wei-Wei Wu, Yujun Wang, Linghui Kong, Liming Shao, Wei Fu, Dengqi Xue, Yan Ma, Qiong Xie, Hai-hao Wu, Jing-Gen Liu, Li Xiao, Shengyang Fang
Publikováno v:
Journal of Medicinal Chemistry. 62:11054-11070
Effective and safe analgesics represent an unmet medical need for the treatment of acute and chronic pain. A series of N-cyclopropylmethyl-7α-phenyl-6,14-endoethanotetrahydronorthebaines were designed, synthesized, and assayed, leading to the discov
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f428c9fb80b3279f72fe55ee02b21dd7
https://doi.org/10.1021/acs.jmedchem.9b00857
https://doi.org/10.1021/acs.jmedchem.9b00857
Autor:
Huoming, Huang, Xueping, Li, Peng, Xie, Xinwei, Li, XueJun, Xu, Yuanyuan, Qian, Congmin, Yuan, Xiangguo, Meng, JingRui, Chai, Jing, Chen, Jing, Liu, Wenli, Wang, Wei, Li, YuJun, Wang, Wei, Fu, Jinggen, Liu
Publikováno v:
Journal of medicinal chemistry. 64(13)
Management of moderate to severe pain relies heavily on opioid analgesics such as morphine, oxycodone, and fentanyl in clinics. However, their prolonged use was associated with undesirable side effects. Many new strategies to reduce side effects have
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::fac36c5d300a6e7b662190d6d8438e94
https://pubmed.ncbi.nlm.nih.gov/34152138
https://pubmed.ncbi.nlm.nih.gov/34152138
Autor:
Hao Chen, Yuanyuan Qian, Shengyang Fang, Yu-Jun Wang, Yilin Zheng, Qian He, Hai-hao Wu, Liming Shao, Linghui Kong, Xicheng Yang, Jing-Gen Liu, Xiao Liu, Cheng Lin, Huijiao Sun, Wei Li, Wei Fu, Li Xiao, Yu-hua Wang, Lan Zheng, Huoming Huang, Qiong Xie, Dengqi Xue, Zhuibai Qiu, Linqian Yu, Xue-Jun Xu, Congmin Yuan
Publikováno v:
Bioorganic & Medicinal Chemistry. 26:4254-4263
With the purpose of identifying novel selective κ opioid receptor (KOR) antagonists as potential antidepressants from nepenthone analogues, starting from N -nor- N -cyclopropylmethyl-nepenthone (SLL-020ACP), a highly selective and potent KOR agonist
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82806c57c1185d9c1f2125a08c0bd779
https://doi.org/10.1016/j.bmc.2018.07.020
https://doi.org/10.1016/j.bmc.2018.07.020
Autor:
Xinzhou Xu, Pak Hang Peter Cheung, Tin Hang Chong, Lu Zhang, Congmin Yuan, Yuqing Wang, Xuhui Huang
Publikováno v:
Biophysical Chemistry. 277:106652
Favipiravir (T-705) has been developed as a potent anti-influenza drug and exhibited a strong inhibition effect against a broad spectrum of RNA viruses. Its active form, ribofuranosyl-triphosphate (T-705-RTP), functions as a competitive substrate for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6906ca793a1191ff69561d34db8b2db
https://doi.org/10.1016/j.bpc.2021.106652
https://doi.org/10.1016/j.bpc.2021.106652