Pharmacokinetic improvement provided by microneedle patch in delivering bee venom, a case study in combating scopolamine-induced neurodegeneration in mouse model

Autor: Cong Duc Nguyen, Jaehee Yoo, Eun Jin An, Chang Yub Sung, Do Hyeon Jeong, Soo-Yeon Park, Jae-Hong Kim, Gihyun Lee

Publikováno v: Drug Delivery, Vol 29, Iss 1, Pp 2855-2867 (2022)

Much research has shown Bee venom to be an effective neuroprotective agent. However, the usual transdermal injection of bee venom poses many pharmacokinetic disadvantages. Here, we compared the administration of bee venom via subcutaneous injection (

Externí odkaz: https://doaj.org/article/4222e4f500af4927b6690b811aa6a0c8

Effects of Donepezil Treatment on Brain Metabolites, Gut Microbiota, and Gut Metabolites in an Amyloid Beta-Induced Cognitive Impairment Mouse Pilot Model

Autor: Jae-Kwon Jo, Gihyun Lee, Cong Duc Nguyen, Seong-Eun Park, Eun-Ju Kim, Hyun-Woo Kim, Seung-Ho Seo, Kwang-Moon Cho, Sun Jae Kwon, Jae-Hong Kim, Hong-Seok Son

Publikováno v: Molecules, Vol 27, Iss 19, p 6591 (2022)

Accumulated clinical and biomedical evidence indicates that the gut microbiota and their metabolites affect brain function and behavior in various central nervous system disorders. This study was performed to investigate the changes in brain metaboli

Externí odkaz: https://doaj.org/article/0b57387538574e428f96f8b00ec87dba

Insamgobonhwan Protects Neuronal Cells from Lipid ROS and Improves Deficient Cognitive Function

Autor: Ji Hye Yang, Cong Duc Nguyen, Gihyun Lee, Chang-Su Na

Publikováno v: Antioxidants, Vol 11, Iss 2, p 295 (2022)

Iron is an essential element in the central nervous system that is involved in many of its important biological processes, such as oxygen transportation, myelin production, and neurotransmitter synthesis. Previous studies have observed the selective

Externí odkaz: https://doaj.org/article/5cea066f71a54e2aba052b98f4670e24

Bee Venom Activates the Nrf2/HO-1 and TrkB/CREB/BDNF Pathways in Neuronal Cell Responses against Oxidative Stress Induced by Aβ1–42

Autor: Cong Duc Nguyen, Jaehee Yoo, Sun-Young Hwang, Sung-Young Cho, Myeonghun Kim, Hyemin Jang, Kyoung Ok No, Jeong Cheol Shin, Jae-Hong Kim, Gihyun Lee

Publikováno v: International Journal of Molecular Sciences; Volume 23; Issue 3; Pages: 1193
International Journal of Molecular Sciences, Vol 23, Iss 1193, p 1193 (2022)

Honeybee venom has recently been considered an anti-neurodegenerative agent, primarily due to its anti-inflammatory effects. The natural accumulation of amyloid-beta (Aβ) in the brain is reported to be the natural cause of aging neural ability downf

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::074e405c20446ef6b96d0eb1e994fc8f

Bee Venom Activates the Nrf2/HO-1 and TrkB/CREB/BDNF Pathways in Neuronal Cell Responses against Oxidative Stress Induced by Aβ

Autor: Cong Duc, Nguyen, Jaehee, Yoo, Sun-Young, Hwang, Sung-Young, Cho, Myeonghun, Kim, Hyemin, Jang, Kyoung Ok, No, Jeong Cheol, Shin, Jae-Hong, Kim, Gihyun, Lee

Publikováno v: International journal of molecular sciences. 23(3)

Honeybee venom has recently been considered an anti-neurodegenerative agent, primarily due to its anti-inflammatory effects. The natural accumulation of amyloid-beta (Aβ) in the brain is reported to be the natural cause of aging neural ability downf

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::3ce75f19a74c71487c9618a60cc80942
https://pubmed.ncbi.nlm.nih.gov/35163115