Bespoke library docking for 5-HT 2A receptor agonists with antidepressant activity.

Autor: Kaplan AL; Department of Pharmaceutical Chemistry, University of California, San Francisco, CA, USA., Confair DN; Department of Chemistry, Yale University, New Haven, CT, USA., Kim K; Department of Pharmacology, University of North Carolina, Chapel Hill School of Medicine, Chapel Hill, NC, USA.; Department of Pharmacy, Yonsei University, Incheon, Republic of Korea., Barros-Álvarez X; Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA, USA., Rodriguiz RM; Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC, USA.; Mouse Behavioral and Neuroendocrine Analysis Core Facility, Duke University Medical Center, Durham, NC, USA., Yang Y; Department of Pharmaceutical Chemistry, University of California, San Francisco, CA, USA., Kweon OS; Department of Chemistry, Yale University, New Haven, CT, USA., Che T; Center for Clinical Pharmacology, Department of Anesthesiology, Washington University School of Medicine, St Louis, MO, USA., McCorvy JD; Department of Cell Biology, Neurobiology and Anatomy, Medical College of Wisconsin, Milwaukee, WI, USA., Kamber DN; Department of Chemistry, Yale University, New Haven, CT, USA., Phelan JP; Department of Chemistry, Yale University, New Haven, CT, USA., Martins LC; Department of Pharmaceutical Chemistry, University of California, San Francisco, CA, USA.; Biochemistry Department, Institute for Biological Sciences, Federal University of Minas Gerais, Belo Horizonte, Brazil., Pogorelov VM; Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC, USA., DiBerto JF; Department of Pharmacology, University of North Carolina, Chapel Hill School of Medicine, Chapel Hill, NC, USA., Slocum ST; Department of Pharmacology, University of North Carolina, Chapel Hill School of Medicine, Chapel Hill, NC, USA., Huang XP; National Institute of Mental Health Psychoactive Drug Screening Program, University of North Carolina Chapel Hill School of Medicine, Chapel Hill, NC, USA., Kumar JM; Department of Pharmacology, University of North Carolina, Chapel Hill School of Medicine, Chapel Hill, NC, USA., Robertson MJ; Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA, USA., Panova O; Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA, USA., Seven AB; Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA, USA., Wetsel AQ; Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC, USA., Wetsel WC; Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC, USA. william.wetsel@duke.edu.; Mouse Behavioral and Neuroendocrine Analysis Core Facility, Duke University Medical Center, Durham, NC, USA. william.wetsel@duke.edu.; Department of Cell Biology, Duke University Medical Center, Durham, NC, USA. william.wetsel@duke.edu.; Department of Neurobiology, Duke University Medical Center, Durham, NC, USA. william.wetsel@duke.edu., Irwin JJ; Department of Pharmaceutical Chemistry, University of California, San Francisco, CA, USA. jji@cgl.ucsf.edu., Skiniotis G; Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA, USA. yiorgo@stanford.edu., Shoichet BK; Department of Pharmaceutical Chemistry, University of California, San Francisco, CA, USA. bshoichet@gmail.com., Roth BL; Department of Pharmacology, University of North Carolina, Chapel Hill School of Medicine, Chapel Hill, NC, USA. bryan_roth@med.unc.edu.; Division of Chemical Biology and Medicinal Chemistry, Eshelman School of Pharmacy, University of North Carolina Chapel Hill, Chapel Hill, NC, USA. bryan_roth@med.unc.edu., Ellman JA; Department of Chemistry, Yale University, New Haven, CT, USA. jonathan.ellman@yale.edu.

Publikováno v: Nature [Nature] 2022 Oct; Vol. 610 (7932), pp. 582-591. Date of Electronic Publication: 2022 Sep 28.

Rh(III)-Catalyzed Imidoyl C-H Carbamylation and Cyclization to Bicyclic [1,3,5]Triazinones.

Autor: Confair DN; Department of Chemistry, Yale University, New Haven, Connecticut 06520, United States., Greenwood NS; Department of Chemistry, Yale University, New Haven, Connecticut 06520, United States., Mercado BQ; Department of Chemistry, Yale University, New Haven, Connecticut 06520, United States., Ellman JA; Department of Chemistry, Yale University, New Haven, Connecticut 06520, United States.

Publikováno v: Organic letters [Org Lett] 2020 Nov 20; Vol. 22 (22), pp. 8993-8997. Date of Electronic Publication: 2020 Nov 10.