PBRM1 mutations might render a subtype of biliary tract cancers sensitive to drugs targeting the DNA damage repair system

Autor: Zimmer, Kai, Kocher, Florian, Untergasser, Gerold, Kircher, Brigitte, Amann, Arno, Baca, Yasmine, Macarulla, Teresa, Tabernero, Josep

Publikováno v: Scientia

Cancer genomics; Oncology Genómica del cáncer; Oncología Genòmica del càncer; Oncologia Polybromo-1 (PBRM1) loss of function mutations are present in a fraction of biliary tract cancers (BTCs). PBRM1, a subunit of the PBAF chromatin-remodeling c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______3991::85bf64e2c4230b124ae9de2de62f059f
https://hdl.handle.net/11351/9989

Percutaneous transhepatic or endoscopic ultrasound-guided biliary drainage in malignant distal bile duct obstruction using a self-expanding metal stent: Study protocol for a prospective European multicenter trial (PUMa trial)

Autor: Daniel Schmitz, Carlos T. Valiente, Markus Dollhopf, Manuel Perez-Miranda, Armin Küllmer, Joan Gornals, Juan Vila, Jochen Weigt, Torsten Voigtländer, Eduardo Redondo-Cerezo, Thomas von Hahn, Jörg Albert, Stephan vom Dahl, Torsten Beyna, Dirk Hartmann, Franziska Franck, Francisco Javier García-Alonso, Arthur Schmidt, Albert Garcia-Sumalla, Amaia Arrubla, Markus Joerdens, Tobias Kleemann, José Ramón Aparicio Tomo, Felix Grassmann, Jochen Rudi

Background Endoscopic ultrasound-guided biliary drainage (EUS-BD) was associated with better clinical success and a lower rate of adverse events (AEs) than fluoroscopy-guided percutaneous transhepatic biliary drainage (PTBD) in recent single center s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e0fbe3f3ea30300d955a477c5ef26e4
http://hdl.handle.net/2445/196686

Machine Learning-Based Analysis in the Management of Iatrogenic Bile Duct Injury During Cholecystectomy: a Nationwide Multicenter Study

Autor: Victor Lopez-Lopez, Javier Maupoey, Rafael López-Andujar, Emilio Ramos, Kristel Mils, Pedro Antonio Martinez, Andres Valdivieso, Marina Garcés-Albir, Luis Sabater, Luis Díez Valladares, Sergio Annese Pérez, Benito Flores, Roberto Brusadin, Asunción López Conesa, Valentin Cayuela, Sagrario Martinez Cortijo, Sandra Paterna, Alejando Serrablo, Santiago Sánchez-Cabús, Antonio González Gil, Jose Antonio González Masía, Carmelo Loinaz, Jose Luis Lucena, Patricia Pastor, Cristina Garcia-Zamora, Alicia Calero, Juan Valiente, Antonio Minguillon, Fernando Rotellar, Jose Manuel Ramia, Cándido Alcazar, Javier Aguilo, Jose Cutillas, Christoph Kuemmerli, Jose A. Ruiperez-Valiente, Ricardo Robles-Campos

Publikováno v: JOURNAL OF GASTROINTESTINAL SURGERY
r-IIS La Fe. Repositorio Institucional de Producción Científica del Instituto de Investigación Sanitaria La Fe
instname
r-INCLIVA. Repositorio Institucional de Producción Científica de INCLIVA
Consejo Superior de Investigaciones Científicas (CSIC)
r-ISABIAL. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica y Sanitaria de Alicante
r-FISABIO. Repositorio Institucional de Producción Científica
r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
Dipòsit Digital de la UB
Universidad de Barcelona

Background Iatrogenic bile duct injury (IBDI) is a challenging surgical complication. IBDI management can be guided by artificial intelligence models. Our study identified the factors associated with successful initial repair of IBDI and predicted th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78d57dc36d058609063b1d9cac4711de
http://hdl.handle.net/2445/187831

Atresia de vías biliares : pronóstico a largo plazo

Autor: Bueno Recio, Francisco Javier, Broto Mangues, Jesús, Armengol Carrasco, Manuel

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______272::a43f2f6d6e2ce32c6412ebd5e5327385
https://hdl.handle.net/2072/420551

Fibrates for the treatment of cholestatic itch (FITCH): study protocol for a randomized controlled trial

Autor: Bolier, R., Vries, E.S. de, Pares, A., Helder, J., Kemper, E.M., Zwinderman, K., Elferink, R.P., Beuers, U., Buuren, H.R. van, Drenth, J.P., Erpecum, K.J. van, Hoek, B. van, Jansen, P.L.M., Nieuwkerk, K.M. van, Vree, J.M. de

Publikováno v: Trials
Trials, 18
Trials, 18(1). BioMed Central
Recercat. Dipósit de la Recerca de Catalunya
instname
Dipòsit Digital de la UB
Universidad de Barcelona
Trials, Vol 18, Iss 1, Pp 1-9 (2017)

Background Pruritus (itch) is a frequent, burdensome and difficult-to-treat symptom in patients with cholestasis. Fibrates are currently under investigation for the treatment of primary biliary cholangitis in patients with a suboptimal response to ur

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dbaa2ba5591a9c13c116bcb386646a38
https://hdl.handle.net/1887/94733