Methylene Blue Is a Nonspecific Protein–Protein Interaction Inhibitor with Potential for Repurposing as an Antiviral for COVID-19.

Autor: Chuang, Sung-Ting, Papp, Henrietta, Kuczmog, Anett, Eells, Rebecca, Condor Capcha, Jose M., Shehadeh, Lina A., Jakab, Ferenc, Buchwald, Peter

Publikováno v: Pharmaceuticals (14248247); May2022, Vol. 15 Issue 5, p621-621, 16p

Growth hormone-releasing hormone receptor antagonist MIA-602 attenuates cardiopulmonary injury induced by BSL-2 rVSV-SARS-CoV-2 in hACE2 mice.

Autor: Condor Capcha JM; Department of Medicine, Division of Cardiology, University of Miami Leonard M. Miller School of Medicine, Miami, FL 33136.; Interdisciplinary Stem Cell Institute, University of Miami Leonard M. Miller School of Medicine, Miami, FL 33136., Kamiar A; Department of Medicine, Division of Cardiology, University of Miami Leonard M. Miller School of Medicine, Miami, FL 33136.; Interdisciplinary Stem Cell Institute, University of Miami Leonard M. Miller School of Medicine, Miami, FL 33136., Robleto E; Department of Medicine, Division of Cardiology, University of Miami Leonard M. Miller School of Medicine, Miami, FL 33136.; Interdisciplinary Stem Cell Institute, University of Miami Leonard M. Miller School of Medicine, Miami, FL 33136., Saad AG; Department of Pathology, University of Miami Leonard M. Miller School of Medicine, Miami, FL 33136., Cui T; Research Service, Miami Veterans Affairs Health System (VAHS), Miami, FL 33125.; Department of Medicine, Division of Pulmonary, Critical Care and Sleep Medicine, University of Miami Miller School of Medicine, Miami, FL 33101., Wong A; Department of Molecular and Comparative Pathobiology, Johns Hopkins University, Baltimore, MD 21205., Villano J; Department of Molecular and Comparative Pathobiology, Johns Hopkins University, Baltimore, MD 21205., Zhong W; W. Harry Feinstone Department of Molecular Microbiology and Immunology, Johns Hopkins University, Baltimore, MD 21205., Pekosz A; W. Harry Feinstone Department of Molecular Microbiology and Immunology, Johns Hopkins University, Baltimore, MD 21205., Medina E; Qualityminds Gesellschaft mit beschränkter Haftung (GmbH), Munchen, Munich 81549, Germany., Cai R; Interdisciplinary Stem Cell Institute, University of Miami Leonard M. Miller School of Medicine, Miami, FL 33136.; Research Service, Miami Veterans Affairs Health System (VAHS), Miami, FL 33125.; Department of Medicine, Division of Pulmonary, Critical Care and Sleep Medicine, University of Miami Miller School of Medicine, Miami, FL 33101., Sha W; Research Service, Miami Veterans Affairs Health System (VAHS), Miami, FL 33125.; Department of Medicine, Division of Pulmonary, Critical Care and Sleep Medicine, University of Miami Miller School of Medicine, Miami, FL 33101., Ranek MJ; Division of Cardiology, Department of Medicine, Johns Hopkins University, Baltimore, MD 21205.; Department of Pharmacology and Molecular Sciences, Johns Hopkins University, Baltimore, MD 21205., Webster KA; Integene International Holdings, Miami, FL 33179.; Baylor College of Medicine, Houston, TX 77030., Schally AV; Interdisciplinary Stem Cell Institute, University of Miami Leonard M. Miller School of Medicine, Miami, FL 33136.; Research Service, Miami Veterans Affairs Health System (VAHS), Miami, FL 33125.; Department of Medicine, Division of Pulmonary, Critical Care and Sleep Medicine, University of Miami Miller School of Medicine, Miami, FL 33101., Jackson RM; Research Service, Miami Veterans Affairs Health System (VAHS), Miami, FL 33125.; Department of Medicine, Division of Pulmonary, Critical Care and Sleep Medicine, University of Miami Miller School of Medicine, Miami, FL 33101., Shehadeh LA; Department of Medicine, Division of Cardiology, University of Miami Leonard M. Miller School of Medicine, Miami, FL 33136.; Interdisciplinary Stem Cell Institute, University of Miami Leonard M. Miller School of Medicine, Miami, FL 33136.

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2023 Nov 28; Vol. 120 (48), pp. e2308342120. Date of Electronic Publication: 2023 Nov 20.