Cost-Effective and Scalable Clonal Hematopoiesis Assay Provides Insight into Clonal Dynamics.

Autor: Mack T; Vanderbilt Genetics Institute, Vanderbilt University School of Medicine, Nashville, Tennessee., Vlasschaert C; Department of Medicine, Queen's University, Kingston, Ontario, Canada., von Beck K; Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee., Silver AJ; Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee; Program in Cancer Biology, Vanderbilt University School of Medicine, Nashville, Tennessee., Heimlich JB; Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee., Poisner H; Vanderbilt Genetics Institute, Vanderbilt University School of Medicine, Nashville, Tennessee., Condon HR; Vanderbilt Genetics Institute, Vanderbilt University School of Medicine, Nashville, Tennessee., Ulloa J; Vanderbilt Genetics Institute, Vanderbilt University School of Medicine, Nashville, Tennessee., Sochacki AL; Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee., Spaulding TP; Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee., Kishtagari A; Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee., Bejan CA; Department of Biomedical Informatics, Vanderbilt University Medical Center, Nashville, Tennessee., Xu Y; Department of Biomedical Informatics, Vanderbilt University Medical Center, Nashville, Tennessee; Department of Biostatistics, Vanderbilt University Medical Center, Nashville, Tennessee., Savona MR; Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee; Program in Cancer Biology, Vanderbilt University School of Medicine, Nashville, Tennessee; Vanderbilt Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, Tennessee; Center for Immunobiology, Vanderbilt University Medical Center, Nashville, Tennessee., Jones A; Vanderbilt Genetics Institute, Vanderbilt University School of Medicine, Nashville, Tennessee., Bick AG; Vanderbilt Genetics Institute, Vanderbilt University School of Medicine, Nashville, Tennessee; Division of Genetic Medicine, Vanderbilt University Medical Center, Nashville, Tennessee. Electronic address: alexander.bick@vumc.org.

Publikováno v: The Journal of molecular diagnostics : JMD [J Mol Diagn] 2024 Jul; Vol. 26 (7), pp. 563-573. Date of Electronic Publication: 2024 Apr 06.

Demonstrating paths for unlocking the value of cloud genomics through cross cohort analysis.

Autor: Deflaux N; Verily Life Sciences, San Francisco, CA, USA., Selvaraj MS; Program in Medical and Population Genetics and the Cardiovascular Disease Initiative, Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA.; Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA, USA.; Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA., Condon HR; Division of Genetic Medicine, Vanderbilt University Medical Center, Nashville, TN, USA., Mayo K; Vanderbilt Institute for Clinical and Translational Research, Vanderbilt University Medical Center, Nashville, TN, USA., Haidermota S; Program in Medical and Population Genetics and the Cardiovascular Disease Initiative, Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Division of Cardiology, Massachusetts General Hospital, Boston, MA, USA., Basford MA; Vanderbilt Institute for Clinical and Translational Research, Vanderbilt University Medical Center, Nashville, TN, USA., Lunt C; All of Us Research Program, National Institutes of Health, Bethesda, MD, USA., Philippakis AA; Broad Institute of Harvard and MIT, Cambridge, MA, USA., Roden DM; Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.; Department of Pharmacology, Vanderbilt University Medical Center, Nashville, TN, USA.; Department of Biomedical Informatics, Vanderbilt University Medical Center, Nashville, TN, USA., Denny JC; All of Us Research Program, National Institutes of Health, Bethesda, MD, USA., Musick A; All of Us Research Program, National Institutes of Health, Bethesda, MD, USA., Collins R; Nuffield Department of Population Health, University of Oxford, Oxford, Oxfordshire, UK.; UK Biobank, Cheadle, Stockport, UK., Allen N; Nuffield Department of Population Health, University of Oxford, Oxford, Oxfordshire, UK.; UK Biobank, Cheadle, Stockport, UK., Effingham M; UK Biobank, Cheadle, Stockport, UK., Glazer D; Verily Life Sciences, San Francisco, CA, USA., Natarajan P; Program in Medical and Population Genetics and the Cardiovascular Disease Initiative, Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA.; Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA, USA.; Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.; Division of Cardiology, Massachusetts General Hospital, Boston, MA, USA., Bick AG; Division of Genetic Medicine, Vanderbilt University Medical Center, Nashville, TN, USA. alexander.bick@vumc.org.

Publikováno v: Nature communications [Nat Commun] 2023 Sep 05; Vol. 14 (1), pp. 5419. Date of Electronic Publication: 2023 Sep 05.