Výsledky vyhledávání - "Conditioning, Operant/*drug effects"

Hypocretin/orexin deficiency decreases cocaine abuse liability

Autor: Luis de Lecea, Masashi Yanagisawa, Clara Rossetti, Nadia Steiner, Pierre J. Magistretti, Benjamin Boutrel, Takeshi Sakurai, Olivier Halfon

Publikováno v: Neuropharmacology, vol. 133, pp. 395-403

Compelling evidence indicates that hypocretin/orexin signaling regulates arousal, stress and reward-seeking behaviors. However, most studies on drug reward-related processes have so far described the effects of pharmacological blockers disrupting hyp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2a37be2bf5b301e66031d747c66dba4
https://pubmed.ncbi.nlm.nih.gov/29454841

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Glutamate Receptors on Dopamine Neurons Control the Persistence of Cocaine Seeking

Autor: Rafael Luján, Ainhoa Bilbao, Bénédicte Balland, Briac Halbout, Rolf Sprengel, Carles Sanchis-Segura, Christian Lüscher, Rainer Spanagel, Günther Schütz, Jan Rodriguez Parkitna, David Engblom, Lionel Dahan, Rosanna Parlato, Stephanie Perreau-Lenz, Manuel Mameli

Publikováno v: Neuron, Vol. 59, No 3 (2008) pp. 497-508
Neuron

SummaryCocaine strengthens excitatory synapses onto midbrain dopamine neurons through the synaptic delivery of GluR1-containing AMPA receptors. This cocaine-evoked plasticity depends on NMDA receptor activation, but its behavioral significance in the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c508e5294c1eb524bd95b3918f34b0a9

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GABA neurons of the VTA drive conditioned place aversion

Autor: Jana Doehner, Gwenaël Labouèbe, Julie J. Mirzabekov, Karl Deisseroth, Christian Lüscher, Kelly R. Tan, Marc Turiault, Kay M. Tye, Cédric Yvon

Publikováno v: Neuron
Neuron, Vol. 73, No 6 (2012) pp. 1173-83

SummarySalient but aversive stimuli inhibit the majority of dopamine (DA) neurons in the ventral tegmental area (VTA) and cause conditioned place aversion (CPA). The cellular mechanism underlying DA neuron inhibition has not been investigated and the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8f2a894f9e006966d9cefc2e6e4efc7
https://pubmed.ncbi.nlm.nih.gov/22445344

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Effects of striatal or accumbens lesions on the amphetamine-induced abolition of latent inhibition

Autor: Maria Konstandi, E. Kafetzopoulos

Publikováno v: Pharmacology Biochemistry and Behavior. 44:751-754

In this study, we tested the effects of nucleus accumbens or corpus striatum lesions on the abolition of latent inhibition induced by d-amphetamine. In the latent inhibition paradigm, animals learn to ignore a repeatedly presented nonreinforced stimu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3bdf5975996495bd558e0584e50c5dc2
https://doi.org/10.1016/0091-3057(93)90001-a

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Involvement of adenosine A1 and A2A receptors in the adenosinergic modulation of the discriminative-stimulus effects of cocaine and methamphetamine in rats

Autor: Justinova, Z., Ferre, S., Segal, P. N., Antoniou, K., Solinas, M., Pappas, L. A., Highkin, J. L., Hockemeyer, J., Munzar, P., Goldberg, S. R.

Adenosine, by acting on adenosine A1 and A2A receptors, is known to antagonistically modulate dopaminergic neurotransmission. We have recently reported that nonselective adenosine receptor antagonists (caffeine and 3,7-dimethyl-1-propargylxanthine) c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_____10561::0cd69520ff275823c294882362fcd532
http://olympias.lib.uoi.gr/jspui/handle/123456789/20636

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