Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Condie E. Carmack"'
Autor:
Richard R. Hardy, Susan A. Shinton, David L. Wiest, Condie E. Carmack, T. Manser, R. Wasserman, Kyoko Hayakawa, Yue-Sheng Li
Publikováno v:
The Journal of Experimental Medicine
The expression of different sets of immunoglobulin specificities by fetal and adult B lymphocytes is a long-standing puzzle in immunology. Recently it has become clear that production of immunoglobulin μ heavy chain and subsequent assembly with a su
Resolution and characterization of pro-B and pre-pro-B cell stages in normal mouse bone marrow. 1991
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 189(7)
Autor:
Stephen R. Schramm, Getachew Sequar, Lisa D. Taylor, Robert M. Kay, Kay M. Higgins, Susan L. O'Donnell, Condie E. Carmack, Cllve S. Woodhouse, Roshanak Mashayekh, Dennis Huszar, Nils Lonberg, Chlung-Chi Kuo
Publikováno v:
International Immunology. 6:579-591
We have generated transgenic mice that contain human-sequence Ig miniloci and, because they are also homozygous for a targeted disruption of their endogenous heavy chain genes, must rely on the transgene sequences for B cell receptor expression. Alth
Autor:
Condie E. Carmack, Seth H. Pincus
Publikováno v:
Molecular Immunology. 29:811-819
Antibodies elicited by the synthetic polypeptide antigen (T,G)-A-L are directed against two distinct epitopes. The majority of antibodies bind to a GT containing epitope and bear an idiotope defined by monoclonal antibodies I7 and I9. In this study,
Publikováno v:
Annals of the New York Academy of Sciences. 651:346-353
Autor:
Condie E. Carmack, Nils Lonberg, Kay M. Higgins, Roshanak Mashayekh, Robert M. Kay, Lisa D. Taylor, Chiung-Chi Kuo, Stephen R. Schramm, Clive S. Woodhouse
Publikováno v:
Nucleic Acids Research. 20:6287-6295
We have generated transgenic mice that express a diverse repertoire of human sequence immunoglobulins. The expression of this repertoire is directed by light and heavy chain minilocus transgenes comprised of human protein coding sequences in an unrea
Autor:
D. F. Friedman, Leslie E. Silberstein, Condie E. Carmack, J Goldman, E. C. Besa, R. R. Hardy, Eun Ah Cho
Publikováno v:
The Journal of Experimental Medicine
To study the association of autoimmunity and human B cell neoplasia, we have established a model of a B cell lymphoma which expresses a pathogenic autoantibody of defined specificity. The Ig VH gene expressed in this neoplasm was analyzed longitudina
Publikováno v:
The Journal of Experimental Medicine
We have resolved B220+ IgM- B-lineage cells in mouse bone marrow into four fractions based on differential cell surface expression of determinants recognized by S7 (leukosialin, CD43), BP-1, and 30F1 (heat stable antigen). Functional differences amon
Autor:
Condie E. Carmack, Richard R. Hardy, Marko Z. Radic, Jan Erikson, Sally A. Camper, Martin Weigert
Publikováno v:
Nature. 349:331-334
Self-reactive B cells can be regulated by either deletion or inactivation. These manifestations of self-tolerance have been dramatically shown in transgenic mice in which the number of self-reactive cells has been artificially expanded. We have now e
Autor:
Condie E. Carmack, A. Craig Chinault, Sung-Hae L. Kang, Zhishuo Ou, Chad A. Shaw, Lisa D. White, Sau Wai Cheung, Ankita Patel, Arthur L. Beaudet
Publikováno v:
Genetics in medicine : official journal of the American College of Medical Genetics. 10(4)
Purpose: The goal of this work was to test the ability of oligonucleotide-based arrays to reproduce the results of focused bacterial artificial chromosome (BAC)-based arrays used clinically in comparative genomic hybridization experiments to detect c