Gemini Cationic Lipid-Type Nanovectors Suitable for the Transfection of Therapeutic Plasmid DNA Encoding for Pro-Inflammatory Cytokine Interleukin-12

Autor: Natalia Sánchez-Arribas, María Martínez-Negro, Clara Aicart-Ramos, Conchita Tros de Ilarduya, Emilio Aicart, Andrés Guerrero-Martínez, Elena Junquera

Publikováno v: Pharmaceutics, Vol 13, Iss 5, p 729 (2021)

Ample evidence exists on the role of interleukin-12 (IL-12) in the response against many pathogens, as well as on its remarkable antitumor properties. However, the unexpected toxicity and disappointing results in some clinical trials are prompting th

Externí odkaz: https://doaj.org/article/64d9904585d1435f96c782422e1ed79d

Simple Mixing Device to Reproducibly Prepare Cationic Lipid-DNA Complexes (Lipoplexes)

Autor: Sadao Hirota, Conchita Tros de Ilarduya, Lee G. Barron, Francis C. Szoka

Publikováno v: BioTechniques, Vol 27, Iss 2, Pp 286-290 (1999)

Externí odkaz: https://doaj.org/article/78ce1038a2644d929d0e4fa4ef788fcb

Trifaceted Mickey Mouse Amphiphiles for Programmable Self-Assembly, DNA Complexation and Organ-Selective Gene Delivery

Autor: José L. Jiménez Blanco, Conchita Tros de Ilarduya, Christophe Di Giorgio, José M. García Fernández, Juan M. Benito, Carmen Ortiz Mellet, Manuel González-Cuesta, Cédric Przybylski, María L. Santana-Armas, Thais Carmona, Francisco Mendicuti, Ana I. Carbajo-Gordillo

Publikováno v: Chemistry (Weinheim an Der Bergstrasse, Germany)
Chemistry-A European Journal
Chemistry-A European Journal, Wiley-VCH Verlag, 2021, 27 (36), pp.9429-9438. ⟨10.1002/chem.202100832⟩
Digital.CSIC. Repositorio Institucional del CSIC
instname
idUS. Depósito de Investigación de la Universidad de Sevilla
Digital.CSIC: Repositorio Institucional del CSIC
Consejo Superior de Investigaciones Científicas (CSIC)

Instilling segregated cationic and lipophilic domains with an angular disposition in a trehalose‐based trifaceted macrocyclic scaffold allows engineering patchy molecular nanoparticles leveraging directional interactions that emulate those controll

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d3e96916c0d95db121041b5af56e74d

Tuning the Topological Landscape of DNA-Cyclodextrin Nanocomplexes by Molecular Design

Autor: Francisco Mendicuti, José M. García Fernández, Hugo Lana, Gema Marcelo, Ana I. Carbajo-Gordillo, Tania Neva, Juan M. Benito, Conchita Tros de Ilarduya, Carmen Ortiz Mellet

Publikováno v: Chemistry (Weinheim an der Bergstrasse, Germany). 26(66)

Original molecular vectors that ensure broad flexibility to tune the shape and surface properties of plasmid DNA (pDNA) condensates are reported herein. The prototypic design involves a cyclodextrin (CD) platform bearing a polycationic cluster at the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88c2b61fc16be7ff104707fba2b1d077
https://pubmed.ncbi.nlm.nih.gov/32710799

Transfection of plasmid DNA by nanocarriers containing a gemini cationic lipid with an aromatic spacer or its monomeric counterpart

Autor: Ana L. Barrán-Berdón, Clara Aicart-Ramos, Emilio Aicart, Conchita Tros de Ilarduya, María Martínez-Negro, María Luisa Moyá, Elena Junquera

Publikováno v: Colloids and Surfaces B: Biointerfaces. 161:519-527

This study performed a biophysical characterization (electrochemistry, structure and morphology) and assessment of the biological activity and cell biocompatibility of GCL/DOPE-pDNA lipoplexes comprised of plasmid DNA and a mixed lipid formed by a DO

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9921b03738ed373a9a63d370704f970f
https://doi.org/10.1016/j.colsurfb.2017.11.024