Výsledky vyhledávání - "Conchita, Vens"

Akademický článek

Phase I feasibility study of Olaparib in combination with loco-regional radiotherapy in head and neck squamous cell carcinoma

Autor: Arash Navran, Abrahim Al-Mamgani, Hester Elzinga, Rob Kessels, Conchita Vens, Margot Tesselaar, Michiel van den Brekel, Rosemarie de Haan, Baukelien van Triest, Marcel Verheij

Publikováno v: Clinical and Translational Radiation Oncology, Vol 44, Iss , Pp 100698- (2024)

Purpose: PARP-inhibitors have potent radiosensitizing properties in pre-clinical models. To identify the maximum tolerated dose (MTD) of the PARP-inhibitor Olaparib in combination with radiotherapy in patients with head and neck cancer, a single inst

Externí odkaz: https://doaj.org/article/c22c97577d0a4c029edca23d55bcece8

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Akademický článek

Computed tomography-derived radiomic signature of head and neck squamous cell carcinoma (peri)tumoral tissue for the prediction of locoregional recurrence and distant metastasis after concurrent chemo-radiotherapy.

Publikováno v: PLoS ONE, Vol 15, Iss 5, p e0232639 (2020)

INTRODUCTION:In this study, we investigate the role of radiomics for prediction of overall survival (OS), locoregional recurrence (LRR) and distant metastases (DM) in stage III and IV HNSCC patients treated by chemoradiotherapy. We hypothesize that r

Externí odkaz: https://doaj.org/article/1f50694073c642ec9e952dd203183917

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Akademický článek

Biological Determinants of Chemo-Radiotherapy Response in HPV-Negative Head and Neck Cancer: A Multicentric External Validation

Autor: Martijn van der Heijden, Paul B. M. Essers, Monique C. de Jong, Reinout H. de Roest, Sebastian Sanduleanu, Caroline V. M. Verhagen, Olga Hamming-Vrieze, Frank Hoebers, Philippe Lambin, Harry Bartelink, C. René Leemans, Marcel Verheij, Ruud H. Brakenhoff, Michiel W. M. van den Brekel, Conchita Vens

Publikováno v: Frontiers in Oncology, Vol 9 (2020)

Purpose: Tumor markers that are related to hypoxia, proliferation, DNA damage repair and stem cell-ness, have a prognostic value in advanced stage HNSCC patients when assessed individually. Here we aimed to evaluate and validate this in a multifactor

Externí odkaz: https://doaj.org/article/3b05fb098e53417c96657e4cfa21c600

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Disease outcome and associated factors after definitive platinum based chemoradiotherapy for advanced stage HPV-negative head and neck cancer

Autor: Reinout H. de Roest, Martijn van der Heijden, Frederik W.R. Wesseling, Emma J. de Ruiter, Martijn W. Heymans, Chris Terhaard, Marije R. Vergeer, Jan Buter, Lot A. Devriese, Jan Paul de Boer, Arash Navran, Ann Hoeben, Conchita Vens, Michiel van den Brekel, Ruud H. Brakenhoff, C. René Leemans, Frank Hoebers

Publikováno v: de Roest, R H, van der Heijden, M, Wesseling, F W R, de Ruiter, E J, Heymans, M W, Terhaard, C, Vergeer, M R, Buter, J, Devriese, L A, de Boer, J P, Navran, A, Hoeben, A, Vens, C, van den Brekel, M, Brakenhoff, R H, Leemans, C R & Hoebers, F 2022, ' Disease outcome and associated factors after definitive platinum based chemoradiotherapy for advanced stage HPV-negative head and neck cancer ', Radiotherapy and Oncology, vol. 175, pp. 112-121 . https://doi.org/10.1016/j.radonc.2022.08.013
Radiotherapy and Oncology, 175, 112-121. Elsevier Ireland Ltd
Radiotherapy and oncology, 175, 112-121. Elsevier Ireland Ltd

BACKGROUND: Definitive concomitant cisplatin-based chemoradiotherapy (CRT) is the current gold standard for most patients with advanced stage head and neck squamous cell carcinoma (HNSCC) of the pharynx and larynx. Since previous meta-analysis on CRT

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a081d2140a35c3df4f3a4a0fb43a4001
https://doi.org/10.1016/j.radonc.2022.08.013

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