A Side-by-Side Comparison of Wildtype and Variant Melanocortin 1 Receptor Signaling with Emphasis on Protection against Oxidative Damage to DNA

Autor: Sonia Cerdido, José Sánchez-Beltrán, Ana Lambertos, Marta Abrisqueta, Lidia Padilla, Cecilia Herraiz, Conchi Olivares, Celia Jiménez-Cervantes, José C. García-Borrón

Publikováno v: International Journal of Molecular Sciences, Vol 24, Iss 18, p 14381 (2023)

Common variants of the MC1R gene coding the α-melanocyte stimulating hormone receptor are associated with light skin, poor tanning, blond or red hair, and increased melanoma risk, due to pigment-dependent and -independent effects. This complex pheno

Externí odkaz: https://doaj.org/article/3afe1877060a4b0d844bb02069a37c15

Conjugation with Dihydrolipoic Acid Imparts Caffeic Acid Ester Potent Inhibitory Effect on Dopa Oxidase Activity of Human Tyrosinase

Autor: Raffaella Micillo, Julia Sirés-Campos, José Carlos García-Borrón, Lucia Panzella, Alessandra Napolitano, Conchi Olivares

Publikováno v: International Journal of Molecular Sciences, Vol 19, Iss 8, p 2156 (2018)

Caffeic acid derivatives represent promising lead compounds in the search for tyrosinase inhibitors to be used in the treatment of skin local hyperpigmentation associated to an overproduction or accumulation of melanin. We recently reported the marke

Externí odkaz: https://doaj.org/article/2126830454ad4349b3476ccb3a52c9f6

Mahogunin Ring Finger 1 Is Required for Genomic Stability and Modulates the Malignant Phenotype of Melanoma Cells

Autor: Julia Sirés-Campos, Conchi Olivares, Celia Jiménez-Cervantes, Idoya Martínez-Vicente, José C. García-Borrón, Dorothy C. Bennett, Marta Abrisqueta, María Castejón-Griñán, Cecilia Herraiz

Publikováno v: Cancers
Volume 12
Issue 10
Cancers, Vol 12, Iss 2840, p 2840 (2020)

The mouse mahoganoid mutation abrogating Mahogunin Ring Finger-1 (MGRN1) E3 ubiquitin ligase expression causes hyperpigmentation, congenital heart defects and neurodegeneration. To study the pathophysiology of MGRN1 loss, we compared Mgrn1-knockout m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af95fb77ecba31031e6c59ee95f6ba9d
https://openaccess.sgul.ac.uk/id/eprint/112462/1/cancers-12-02840.pdf

cAMP-independent non-pigmentary actions of variant melanocortin 1 receptor: AKT-mediated activation of protective responses to oxidative DNA damage

Autor: Celia Jiménez-Cervantes, Conchi Olivares, Cecilia Herraiz, María Castejón-Griñán, José C. García-Borrón

Publikováno v: DIGITUM. Depósito Digital Institucional de la Universidad de Murcia
instname
DIGITUM: Depósito Digital Institucional de la Universidad de Murcia
Universidad de Murcia

The melanocortin 1 receptor gene (MC1R), a well-established melanoma susceptibility gene, regulates the amount and type of melanin pigments formed within epidermal melanocytes. MC1R variants associated with increased melanoma risk promote the product

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c554924cca5ae04558594586b1e860f7
http://hdl.handle.net/10201/105589

Functional Characterization of MC1R-TUBB3 Intergenic Splice Variants of the Human Melanocortin 1 Receptor

Autor: María Castejón-Griñán, Marta Abrisqueta, Cecilia Herraiz, José C. García-Borrón, Conchi Olivares, Celia Jiménez-Cervantes

Publikováno v: PLoS ONE
PLoS ONE, Vol 10, Iss 12, p e0144757 (2015)

The melanocortin 1 receptor gene (MC1R) expressed in melanocytes is a major determinant of skin pigmentation. It encodes a Gs protein-coupled receptor activated by α-melanocyte stimulating hormone (αMSH). Human MC1R has an inefficient poly(A) site

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d46b7cfe06ae93611e8cf7557eaf0c0d
https://doi.org/10.1371/journal.pone.0144757