Zobrazeno 1 - 10
of 179
pro vyhledávání: '"Concettina La Motta"'
Autor:
Lidia Ciccone, Caterina Camodeca, Nicolò Tonali, Lucia Barlettani, Armando Rossello, Carole Fruchart Gaillard, Julia Kaffy, Giovanni Petrarolo, Concettina La Motta, Susanna Nencetti, Elisabetta Orlandini
Publikováno v:
Pharmaceutics, Vol 15, Iss 10, p 2369 (2023)
A series of new hybrid derivatives 1a–c, 2a–c, 3a–c, 4a–c, 5a–c, inspired by nature, were synthesized and studied as multifunctional agents for the treatment of Alzheimer’s disease (AD). These compounds were designed to merge together the
Externí odkaz:
https://doaj.org/article/9600a40359d640529d4c3d967198f601
Autor:
Felicia D'Andrea, Stefania Sartini, Ilaria Piano, Matteo Franceschi, Luca Quattrini, Lorenzo Guazzelli, Lidia Ciccone, Elisabetta Orlandini, Claudia Gargini, Concettina La Motta, Susanna Nencetti
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 35, Iss 1, Pp 1194-1205 (2020)
Aldose reductase is a key enzyme in the development of long term diabetic complications and its inhibition represents a viable therapeutic solution for people affected by these pathologies. Therefore, the search for effective aldose reductase inhibit
Externí odkaz:
https://doaj.org/article/2b923e0da4124b2f977b2ce22fca760a
Autor:
Serena Del Turco, Luca Quattrini, Rocchina Colucci, Melania Gaggini, Concettina La Motta, Giuseppina Basta
Publikováno v:
Saudi Pharmaceutical Journal, Vol 27, Iss 8, Pp 1174-1181 (2019)
Low-grade chronic inflammation is a key process of angiogenesis in tumour progression. We investigated whether a synthetic analogue of apigenin, the 2-(3,4-dimethoxyphenyl)-3-phenyl-4H-pyrido[1,2-a] pyrimidin-4-one (called DB103), interfered with the
Externí odkaz:
https://doaj.org/article/e4072e7a9d394cbdb145d6a4ec44cf70
Autor:
Carmen Herranz, Francesca Mateo, Alexandra Baiges, Gorka Ruiz de Garibay, Alexandra Junza, Simon R Johnson, Suzanne Miller, Nadia García, Jordi Capellades, Antonio Gómez, August Vidal, Luis Palomero, Roderic Espín, Ana I Extremera, Eline Blommaert, Eva Revilla‐López, Berta Saez, Susana Gómez‐Ollés, Julio Ancochea, Claudia Valenzuela, Tamara Alonso, Piedad Ussetti, Rosalía Laporta, Antoni Xaubet, José A Rodríguez‐Portal, Ana Montes‐Worboys, Carlos Machahua, Jaume Bordas, Javier A Menendez, Josep M Cruzado, Roser Guiteras, Christophe Bontoux, Concettina La Motta, Aleix Noguera‐Castells, Mario Mancino, Enrique Lastra, Raúl Rigo‐Bonnin, Jose C Perales, Francesc Viñals, Alvaro Lahiguera, Xiaohu Zhang, Daniel Cuadras, Coline H M vanMoorsel, Joanne J van derVis, Marian J R Quanjel, Harilaos Filippakis, Razq Hakem, Chiara Gorrini, Marc Ferrer, Aslihan Ugun‐Klusek, Ellen Billett, Elżbieta Radzikowska, Álvaro Casanova, María Molina‐Molina, Antonio Roman, Oscar Yanes, Miquel A Pujana
Publikováno v:
EMBO Molecular Medicine, Vol 13, Iss 9, Pp n/a-n/a (2021)
Abstract Inhibition of mTOR is the standard of care for lymphangioleiomyomatosis (LAM). However, this therapy has variable tolerability and some patients show progressive decline of lung function despite treatment. LAM diagnosis and monitoring can al
Externí odkaz:
https://doaj.org/article/51f572bcdff644bcab3c3cc538fd0d47
Autor:
Alessandra Bertoli, Anthea LoBue, Luca Quattrini, Stefania Sartini, Beatrice Polini, Sara Carpi, Francesco Paolo Frontini, Graziano Di Giuseppe, Graziano Guella, Paola Nieri, Concettina La Motta
Publikováno v:
Marine Drugs, Vol 20, Iss 11, p 682 (2022)
Euplotin C is a sesquiterpene of marine origin endowed with significant anti-microbial and anti-tumor properties. Despite the promising functional profile, its progress as a novel drug candidate has failed so far, due to its scarce solubility and poo
Externí odkaz:
https://doaj.org/article/457c4ed412bd4fa08ec6b729f0910267
Publikováno v:
Antioxidants, Vol 11, Iss 10, p 1931 (2022)
Carotenoids are bioactive compounds provided by the diet playing a key role in maintaining human health. Therefore, they should be ingested daily in an adequate amount. However, even a varied and well-balanced diet does not guarantee an adequate inta
Externí odkaz:
https://doaj.org/article/5908347ff29e49519faf732124a359d2
Autor:
Luca Campisi, Concettina La Motta
Publikováno v:
Antioxidants, Vol 11, Iss 10, p 1969 (2022)
The coenzyme Q10 is a naturally occurring benzoquinone derivative widely prescribed as a food supplement for different physical conditions and pathologies. This review aims to sum up the key structural and functional characteristics of Q10, taking st
Externí odkaz:
https://doaj.org/article/492f81b1c5fa4d6184cdf02d80cf4beb
Autor:
Francesco Balestri, Marinella De Leo, Carlo Sorce, Mario Cappiello, Luca Quattrini, Roberta Moschini, Carlotta Pineschi, Alessandra Braca, Concettina La Motta, Federico Da Settimo, Antonella Del-Corso, Umberto Mura
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 34, Iss 1, Pp 350-360 (2019)
Seven triterpenoid saponins were identified in methanolic extracts of seeds of the Zolfino bean landrace (Phaseolus vulgaris L.) by HPLC fractionation, revealing their ability to inhibit highly purified human recombinant aldose reductase (hAKR1B1). S
Externí odkaz:
https://doaj.org/article/ced34592d3214c6484a2359c6f64bf53
Autor:
Lidia Ciccone, Giovanni Petrarolo, Francesca Barsuglia, Carole Fruchart-Gaillard, Evelyne Cassar Lajeunesse, Adeniyi T. Adewumi, Mahmoud E. S. Soliman, Concettina La Motta, Elisabetta Orlandini, Susanna Nencetti
Publikováno v:
Biomolecules, Vol 12, Iss 3, p 448 (2022)
Aldose reductase (ALR2) is the enzyme in charge of developing cellular toxicity caused by diabetic hyperglycemia, which in turn leads to the generation of reactive oxygen species triggering oxidative stress. Therefore, inhibiting ALR2 while pursuing
Externí odkaz:
https://doaj.org/article/851554655f0f4db2a4076f3c911da32b
Publikováno v:
Molecules, Vol 27, Iss 1, p 2 (2021)
Deemed as poorly represented in nature, aurones have been often overlooked by researchers compared to other members of the flavonoid superfamily. However, over the past two decades, they have been reassessed by the scientific community, who are incre
Externí odkaz:
https://doaj.org/article/bfc0fb218d644995a382393fb332f888