Zobrazeno 1 - 10
of 38
pro vyhledávání: '"Concetta Ragone"'
Publikováno v:
Journal of Translational Medicine, Vol 22, Iss 1, Pp 1-17 (2024)
Abstract Tumors are mostly characterized by genetic instability, as result of mutations in surveillance mechanisms, such as DNA damage checkpoint, DNA repair machinery and mitotic checkpoint. Defect in one or more of these mechanisms causes additive
Externí odkaz:
https://doaj.org/article/fbff5259b984451397a31a559e3f4eac
Autor:
Beatrice Cavalluzzo, Marie Christine Viuff, Siri Amanda Tvingsholm, Concetta Ragone, Carmen Manolio, Angela Mauriello, Franco M. Buonaguro, Maria Lina Tornesello, Francesco Izzo, Alessandro Morabito, Sine Reker Hadrup, Maria Tagliamonte, Luigi Buonaguro
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 43, Iss 1, Pp 1-14 (2024)
Abstract Background We have recently shown extensive sequence and conformational homology between tumor-associated antigens (TAAs) and antigens derived from microorganisms (MoAs). The present study aimed to assess the breadth of T-cell recognition sp
Externí odkaz:
https://doaj.org/article/232cb0feceb841a0aba8d74cd6d8e5a2
Autor:
Concetta Ragone, Angela Mauriello, Beatrice Cavalluzzo, Ernesta Cavalcanti, Luigi Russo, Carmen Manolio, Simona Mangano, Biancamaria Cembrola, Maria Tagliamonte, Luigi Buonaguro
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
BackgroundIn the present study we investigated whether peptides derived from the entire SARS-CoV-2 proteome share homology to TAAs (tumor-associated antigens) and cross-reactive CD8+ T cell can be elicited by the BNT162b2 preventive vaccine or the SA
Externí odkaz:
https://doaj.org/article/bb9403ce72c24b2db887c1f182e6c1fd
Autor:
Maria Tagliamonte, Beatrice Cavalluzzo, Angela Mauriello, Concetta Ragone, Franco M. Buonaguro, Maria Lina Tornesello, Luigi Buonaguro
Publikováno v:
Molecular Cancer, Vol 22, Iss 1, Pp 1-12 (2023)
Abstract Background The development of cancer immunotherapeutic strategies relies on the identification and validation of optimal target tumor antigens, which should be tumor-specific as well as able to elicit a swift and potent anti-tumor immune res
Externí odkaz:
https://doaj.org/article/9e0b2ce08a274f0097dcbac562ced992
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss Suppl 1 (2023)
Externí odkaz:
https://doaj.org/article/a31a9ee289ff465ea646ef3d8b05015c
Autor:
Carmen Manolio, Concetta Ragone, Beatrice Cavalluzzo, Angela Mauriello, Maria Lina Tornesello, Franco M. Buonaguro, Angelo Salomone Megna, Giovanna D’Alessio, Roberta Penta, Maria Tagliamonte, Luigi Buonaguro
Publikováno v:
Journal of Translational Medicine, Vol 20, Iss 1, Pp 1-20 (2022)
Abstract Background People living with HIV/AIDS (PLWHA) show a reduced incidence for three cancer types, namely breast, prostate and colon cancers. In the present study, we assessed whether a molecular mimicry between HIV epitopes and tumor associate
Externí odkaz:
https://doaj.org/article/11ea7c9d485a4c02a03d6d6b7ad27a54
Autor:
Concetta Ragone, Carmen Manolio, Angela Mauriello, Beatrice Cavalluzzo, Franco M. Buonaguro, Maria Lina Tornesello, Maria Tagliamonte, Luigi Buonaguro
Publikováno v:
Journal of Translational Medicine, Vol 20, Iss 1, Pp 1-18 (2022)
Abstract Background The gut microbiota profile is unique for each individual and are composed by different bacteria species according to individual birth-to-infant transitions. In the last years, the local and systemic effects of microbiota on cancer
Externí odkaz:
https://doaj.org/article/6e13000048164c08b0755c804dbc2f6f
Autor:
Angela Mauriello, Beatrice Cavalluzzo, Carmen Manolio, Concetta Ragone, Antonio Luciano, Antonio Barbieri, Maria Lina Tornesello, Franco M. Buonaguro, Maria Tagliamonte, Luigi Buonaguro
Publikováno v:
Journal of Translational Medicine, Vol 19, Iss 1, Pp 1-12 (2021)
Abstract The host’s immune system may be primed against antigens during the lifetime (e.g. microorganisms antigens—MoAs), and swiftly recalled upon growth of a tumor expressing antigens similar in sequence and structure. C57BL/6 mice were immuniz
Externí odkaz:
https://doaj.org/article/06cc70dad4d54fc1bd6502a49f9329bf
Autor:
Beatrice Cavalluzzo, Concetta Ragone, Angela Mauriello, Annacarmen Petrizzo, Carmen Manolio, Andrea Caporale, Luigi Vitagliano, Menotti Ruvo, Luigi Buonaguro, Maria Tagliamonte
Publikováno v:
Journal of Translational Medicine, Vol 19, Iss 1, Pp 1-10 (2021)
Abstract The antigenicity as well as the immunogenicity of tumor associated antigens (TAAs) may need to be potentiated in order to break the immunological tolerance. To this aim, heteroclitic peptides were designed introducing specific substitutions
Externí odkaz:
https://doaj.org/article/3dc9a84c911147aa88ceca28ee678ec7
Autor:
Maria Tagliamonte, Angela Mauriello, Beatrice Cavalluzzo, Concetta Ragone, Carmen Manolio, Antonio Luciano, Antonio Barbieri, Giuseppe Palma, Giosuè Scognamiglio, Annabella Di Mauro, Maurizio Di Bonito, Maria Lina Tornesello, Franco M. Buonaguro, Luigi Vitagliano, Andrea Caporale, Menotti Ruvo, Luigi Buonaguro
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Tumor Associated Antigens (TAAs) may suffer from an immunological tolerance due to expression on normal cells. In order to potentiate their immunogenicity, heteroclitic peptides (htcPep) were designed according to prediction algorithms. In particular
Externí odkaz:
https://doaj.org/article/2e250e3e95704cb89d81f4e760bcc049