Výsledky vyhledávání

Akademický článek

The HSP90/R2TP assembly chaperone promotes cell proliferation in the intestinal epithelium

Autor: Chloé Maurizy, Claire Abeza, Bénédicte Lemmers, Monica Gabola, Ciro Longobardi, Valérie Pinet, Marina Ferrand, Conception Paul, Julie Bremond, Francina Langa, François Gerbe, Philippe Jay, Céline Verheggen, Nicola Tinari, Dominique Helmlinger, Rossano Lattanzio, Edouard Bertrand, Michael Hahne, Bérengère Pradet-Balade

Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-19 (2021)

RPAP3 is a subunit of the R2TP complex, a co-chaperone of HSP90, with substrate proteins involved in transcription, ribosome biogenesis, DNA repair and cell growth. Here the authors report that deletion of Rpap3 abrogates cell proliferation and homeo

Externí odkaz: https://doaj.org/article/a94c9c9c3f30427b974454354a00e279

Zobrazit plný text záznamu

Akademický článek

Stakeholders’ Perspective on Groundwater Management in Four Water-Stressed Mediterranean Areas: Priorities and Challenges

Publikováno v: Land, Vol 11, Iss 5, p 738 (2022)

Recent studies highlight the fragility of the Mediterranean basin against climate stresses and the difficulties of managing the sustainable development of groundwater resources. In this work, the main issues related to groundwater management have bee

Externí odkaz: https://doaj.org/article/0c28343c67df4385a92de3e55cdf0d16

Zobrazit plný text záznamu

Akademický článek

The Anti-Hiv Candidate Abx464 Dampens Intestinal Inflammation by Triggering Il-22 Production in Activated Macrophages

Autor: Karim Chebli, Laura Papon, Conception Paul, Aude Garcel, Noëlie Campos, Didier Scherrer, Hartmut J. Ehrlich, Michael Hahne, Jamal Tazi

Publikováno v: Scientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)

Abstract The progression of human immunodeficiency virus (HIV) is associated with mucosal damage in the gastrointestinal (GI) tract. This damage enables bacterial translocation from the gut and leads to subsequent inflammation. Dextran sulfate sodium

Externí odkaz: https://doaj.org/article/908d748ddfcb49b68fb516df8640bcdd

Zobrazit plný text záznamu

Plný text ve formátu HTML

Akademický článek

The Wnt-target gene Dlk-1 is regulated by the Prmt5-associated factor Copr5 during adipogenic conversion

Autor: Conception Paul, Claude Sardet, Eric Fabbrizio

Publikováno v: Biology Open, Vol 4, Iss 3, Pp 312-316 (2015)

Protein arginine methyl transferase 5 (Prmt5) regulates various differentiation processes, including adipogenesis. Here, we investigated adipogenic conversion in cells and mice in which Copr5, a Prmt5- and histone-binding protein, was genetically inv

Externí odkaz: https://doaj.org/article/04b8a6c79ac94e308211715ab375ac7b

Zobrazit plný text záznamu

Akademický článek

Sharpin prevents skin inflammation by inhibiting TNFR1-induced keratinocyte apoptosis

Autor: Snehlata Kumari, Younes Redouane, Jaime Lopez-Mosqueda, Ryoko Shiraishi, Malgorzata Romanowska, Stefan Lutzmayer, Jan Kuiper, Conception Martinez, Ivan Dikic, Manolis Pasparakis, Fumiyo Ikeda

Publikováno v: eLife, Vol 3 (2014)

Linear Ubiquitin chain Assembly Complex (LUBAC) is an E3 ligase complex that generates linear ubiquitin chains and is important for tumour necrosis factor (TNF) signaling activation. Mice lacking Sharpin, a critical subunit of LUBAC, spontaneously de

Externí odkaz: https://doaj.org/article/5400ea6fdffd423ba947794f3f1e0aa7

Zobrazit plný text záznamu